Crocus sativus (Safran) : vertus médicinales en extraction alcoolique

Crocus sativus (Safran, Saffron) — famille Iridacées.

Synonymes scientifiques : Crocus sativus subsp Orsini, C sativus subsp palliasi(M)-K, Safran officinarum-Medik.

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 25 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 210 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : chemoprevention du carcinome : hépatique

   Partie usitée : Stigmate.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Noureini SK (2012)

     Extrait Crocin, the main pigment of Crocus sativus L., has been shown to have antiproliferative effects on cancer cells, but the involved mechanisms are only poor understood. This study focused on probable effect of crocin on the immortality of hepatic cancer cells.

   • Selon khorasany AR (2016)

     Extrait The outcome of the above-mentioned mechanisms shows potential therapeutic properties of saffron against liver cancer, hepatotoxicity, fatty liver, hyperlipidemia, stomach cancer, peptic ulcer, colon cancer, ulcerative colitis, diabetes & pancreas cancer & ileum contractions. Saffron, the dried red-orange stigmas of Crocus sativus L, has been known as a flavoring agent, food coloring & traditional herbal medicine.

   • Selon Iranshahi M (2011)

     Extrait The hepatoprotective effects of aqueous & ethanolic extracts of saffron may be due to: 1- antioxidant effects & radical scavenging 2-reduction of CCl 4 metabolic activation by cytochrome P450 inhibition 3- fixation of hepatic cell membrane. These results suggested that aqueous & ethanolic extracts of saffron exhibit hepatoprotective effects against liver damages induced by CCl 4 in mice.

   • Selon Rahbani M (1985)

     Extrait The present study was designed to assess the liver injury as a complication of diabetes mellitus and to evaluate the hepatoprotective properties of ethanolic extract of Saffron (dried stigmas of Crocus sativus L.) in streptozocin-induced diabetes in rats. At the end of the experiment, MDA contents of the liver tissue and serum levels of ALT, AST, AP and bilirubin in Groups 3 were found to be significantly increased as compared to Group 1 (p<0.05) and these serum biomarkers of hepatic injury & liver MDA level in Group 4 were significantly decreased as compared to Group 3 (p<0.05).

   • Selon Azizi M (2019)

     Extrait the present study investigated the effect of hydroalcoholic extract of Crocus sativus petal with antioxidant properties on the changes in inflammatory & enzymatic indices resulting from alcohol use in the male rats' kidney & liver. At the end of the study, the serum concentration of the inflammatory indices, renal enzymes, & hepatic enzymes experienced a significant reduction in all of the intervened groups compared to the negative control group (minimum significant difference: P<0.05) except for the treatment group 1.

2. 2

   Éthylisme, alteration du rein & foie éthylique

   Partie usitée : Tépales.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Milajerdi A (2017)

     Extrait Conclusion: Saffron hydro-alcoholic extract did not considerably improve renal & liver functions in T2DM patients in an 8-week randomized clinical trials. Since, saffron may improve diabetes control and indicate renal& liver protection, this study purposed to illustrate for the first time the effects of saffron extract on some liver and renal functional parameters among diabetic patients.

   • Selon Azizi M (2019)

     Extrait the present study investigated the effect of hydroalcoholic extract of Crocus sativus petal with antioxidant properties on the changes in inflammatory & enzymatic indices resulting from alcohol use in the male rats' kidney & liver. At the end of the study, the serum concentration of the inflammatory indices, renal enzymes, & hepatic enzymes experienced a significant reduction in all of the intervened groups compared to the negative control group (minimum significant difference: P<0.05) except for the treatment group 1.

   • Selon Ramadan A (2012)

     Extrait sativus, Propolis ethanolic extracts alone or in combination for 8 successive weeks to rats was quiet safe & didn't cause any toxic changes in liver & kidney. The possible toxicological effects & in vitro antioxidant activity of the ethanolic extracts of Crocus sativus & Propolis were investigated.

   • Selon khorasany AR (2016)

     Extrait The outcome of the above-mentioned mechanisms shows potential therapeutic properties of saffron against liver cancer, hepatotoxicity, fatty liver, hyperlipidemia, stomach cancer, peptic ulcer, colon cancer, ulcerative colitis, diabetes & pancreas cancer & ileum contractions. Saffron, the dried red-orange stigmas of Crocus sativus L, has been known as a flavoring agent, food coloring & traditional herbal medicine.

   • Selon Bandegi AR (2014)

     Extrait Protective effects of Crocus sativus L. extract & crocin against chronic-stress induced oxidative damage of brain, liver & kidneys in rats.

3. 3

   Diabète mellitus de type II

   Partie usitée : Fleur. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Amato PPG (2024)

     Extrait (saffron, Iridaceae) has been traditionally used for thousands of years as herbal medicine for many diseases, including type-2 diabetes mellitus (T2DM), especially in Sri Lanka. sativus powdered plant, hydroethanolic extract & crocin in reducing fasting blood sugar (FBG), glycated hemoglobin (HbA1c), blood pressure, & other metabolic parameters in patients with T2DM.

   • Selon Rahbani M (1985)

     Extrait The present study was designed to assess the liver injury as a complication of diabetes mellitus and to evaluate the hepatoprotective properties of ethanolic extract of Saffron (dried stigmas of Crocus sativus L.) in streptozocin-induced diabetes in rats. /day intraperitoneal (i.p.) injection of Saffron extract; Group 3, diabetic rats; Group 4, diabetic rats were treated with saffron extract (40 mg kg -1 b.w./day, i.p.) for a period of 8 weeks.

   • Selon Ouahhoud S (2018)

     Extrait The present study investigated for the first time, the Antihyperglycemic effect of tepals & leaves of Crocus sativus in streptozotocin-induced diabetic rats. Group 1: normal control rats (N), received distilled water; group 2: diabetic control rats (D), received distilled water; group 3: treated diabetic rats (TPL), received tepal (TPL) extract; group 4: treated diabetic rats (STG), received stigma (STG) extract; group 5: treated diabetic rats (LF), received leaf (LF) extract and group 6: treated diabetic rats (GLB), received Glibenclamide (GLB).

   • Selon Milajerdi A (2017)

     Extrait Since, saffron may improve diabetes control and indicate renal& liver protection, this study purposed to illustrate for the first time the effects of saffron extract on some liver and renal functional parameters among diabetic patients. Materials & methods: In this double-blind clinical trial, 54 type 2 diabetic patients were randomly recruited to consume either 15 mg saffron extract (n = 27) or placebo capsules (n = 27) twice a day for 8 weeks.

   • Selon Giannoulaki P (2089)

     Extrait Patients-methods: 61 individuals with DMT-1, mean age 48 years old (48.3 ± 14.6), 26 females (42.6%) were randomized to receive a new oral supplement in sachets containing probiotics, prebiotics, magnesium, and Crocus sativus L. The purpose of this study is to assess the effectiveness of saffron in individuals with Diabetes Mellitus type 1 (DMT-1).

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.