Amorphophallus paeonifolius (Lajan) : medicinal properties in alcoholic extraction

Amorphophallus paeonifolius (Lajan, Sèt-chimiz, Nèf-Chimiz, Sèpan, Silver, Seven shirts, Nine shirts, Snake, Argent, Sept chemises, Neuf chemises, Serpent) — family Aracées.

Scientific synonyms : Amorphophallus campanulatus Decne., A chatty-A, Arum decurrens-Blanco.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 14 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 71 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Tuber.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Putri I (2018)

     Excerpt The objective of the present study was to evaluate the antihyperglycemic & antinociceptive potential of methanol extract of Amorphophallus campanulatus corms in Swiss albino mice. A standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight reduced blood glucose level by 40.7%.

   • According to Rahman SS (2020)

     Excerpt However, taboos regarding elephant foot yam are the prominent barrier for diabetic patients to consume this tuber. In conclusion, elephant foot yam tuber is safe & beneficial for patients with diabetes.

   • According to Rahman SS (2021)

     Excerpt Diabetes was induced intraperitoneally by injecting 140 mg/kg body weight of alloxan dose, & 500 mg/kg bd.wt of Amorphophallus paeoniifolius powder was administered orally for six weeks of both diabetic & non-diabetic experimental rats. This study’s objectives were to explore the nutrient analysis of elephant foot yam tuber & observe the anti-hyperglycemic effect on both diabetic and non-diabetic rats.

   • According to Arva HR (2013)

     Excerpt In the present study, the effect of the acetone extract of elephant-foot yam (Amorphophallus paeoniifolius (Dennst.) Nicolson) at 0.1 & 0.25% in the diet of streptozotocin-induced male Wistar diabetic rats was studied. The results clearly indicate that the acetone extract of elephant foot yam is an effective anti-diabetic agent for streptozotocin-induced diabetic rats.

   • According to Rahman SS (2021)

     Excerpt Diabetic patients usually avoid germinated endosperm of sugar palm (GESP) & elephant foot yam tuber (EFYT), fearing that these may further deteriorate existing hyperglycemia. The results clearly showed that these foodstuffs significantly (P < 0.001) reduced FBG levels of alloxan-induced diabetic rats.

2. 2

   Liver disorders: normalisation of serum parameters: AST, ALT, ALP, transaminases, total protein, etc.

   Plant part used: Tuber.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ansil PA (2014)

     Excerpt In this study, we investigated the curative effect of Amorphophallus campanulatus tuber methanolic extract (ACME) on N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma (HCC) in experimental rats. Administration of ACME significantly inhibited the NDEA-induced increase of hepatic nodule incidence, nodule multiplicity, & serum biochemical indices, and improved the hepatocellular architecture in a dose-dependent manner.

   • According to Basu S (2013)

     Excerpt The elevated serum enzymatic levels of AST, ALT, ALP & total protein were significantly restored towards normal by pre‐treatment with ethanolic extract of AC (p<0.001).However, no significant alteration in the liver marker enzymes a&the antioxidant markers in liver tissue was observed in the only extract treated groups when compared to control, indicating their non-toxic nature. Conclusion: The results of this study strongly indicate that ethanolic extract of AC has potent hepatoprotective action against ethanol induced hepatic damage particularly by scavenging free radicals and combating oxidative stress.

   • According to Jain S (2009)

     Excerpt In the present study, the hepatoprotective activity of ethanolic & aqueous extracts of Amorphophallus campanulatus (Roxb.) tubers were evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. The results of this study strongly indicate that AC tubers have potent hepatoprotective action against carbon tetrachloride induced hepatic damage in rats.

   • According to Ansil PN (2011)

     Excerpt Hepatotoxicity was assessed by quantifying the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) & lactate dehydrogenase (LDH). campanulatus tuber n–hexane extract (ACHE) & methanolic extract (ACME) were evaluated using DPPH, hydroxyl radical, reducing power and total antioxidant capacity assays.

   • According to Sharsty R A (2010)

     Excerpt Sharsty R A et al, Isolation & characterization of secondary metabolite from Amorpophallus paeonifolius for hepatoprotective activity Res J of Pharmaceut, Biol & Chem Sciences, 2010; 1(4):429-37 / ISSN: 0975-8585,.

3. 3

   Bacterial infection: Bacillus subtilis, Bacillus megaterium, Staphylococcus aureus, Streptococcus beta-haemolyticus, (Escherichia coli, Shigella dysenteriae, Shigella sonnei, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi

   Plant part used: Tuber.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kan A (2007)

     Excerpt The extract showed significant antibacterial activities against four gram-positive bacteria (Bacillus subtilis, Bacillus megaterium, Staphylococcus aureus, Streptococcus b-haemolyticus) & six gram-negative bacteria (Escherichia coli, Shigella dysenteriae, Shigella sonnei, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi). Antibacterial, antifungal & cytotoxic activities of ethanol extract of tuberous roots of Amorphophallus campanulatus were studied.

   • According to Peraman M (2016)

     Excerpt Among four solvent extracts, aqueous extract exhibit maximum antibacterial activity for Streptococcus aureus – MTCC 737 (3.25 mm zone of inhibition), Klebsiella pneumonia MTCC 109 (0.75 mm zone of inhibition), Pseudomonas aeruginosa MTCC 424 (1.25 mm zone of inhibition) & 1.5 mm of zone of inhibition for Bacillus subtilis MTCC 121. Phytochemical constitution, antioxidant potential, antibacterial & antifungal activity of solvent extract (Aqueous, methanol, ethanol, ethyl acetate) of AP tuber was studied.

   • According to Gomathi M (2019)

     Excerpt Gomathi M et al, Green Synthesis, Characterization & Antibacterial Activity of Silver Nanoparticles Using Amorphophallus paeoniifolius Leaf Extract, J of Cluster Science, 2019; 30:995-1001,.

   • According to Khan A (2008)

     Excerpt Khan A et al, Antibacterial, antifungal & cytotoxic activities of amblyone isolated from Amorphophallus campanulatus, 2008.

   • According to Swain J (2020)

     Excerpt Amorphophallus paeoniifolius is a very common tuber plant having diverse secondary metabolites and palatability levels. The present study highlights the importance of wild tuberous plants in mitigation of food shortage, food disorders, anti-microbial resistance, novel bacterial & viral diseases like MDR-TB & COVID-19.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.