Artemisia absinthium (Gran-Labsent) : medicinal properties in alcoholic extraction

Artemisia absinthium (Gran-Labsent, Larmwaz dayiti, Grande absinthe, Haitian wormwood, Armoise d’Haïti, Gran absenta, Artemisa de Haití) — family Asteracées.

Scientific synonyms : Artemisia-rhaetica Brügger, -Artemisia absinthium var. inspida Stechm., A pendula Salisb., Absinthium officinale Brot., Avulgare Lam..

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 95 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Liver disorders: normalisation of serum levels of ALT, AST, TTG (total thiol group) and TTG (total antioxidant power)

   Plant part used: aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mohammadian A (2016)

     Excerpt Liver enzymes such as aspartate aminotransferase (AST) andalanine aminotransferase (ALT) with total antioxidant power (TAP) & total thiol groups (TTG)concentrations were measured .Results: Levels of ALT, AST and TTG were decreased in the group II compared to the control (group I). Conclusion: Results suggests that alcoholic extract of AA can ameliorate liver toxicity inrats through reducing the serum levels of ALT, AST, & oxidative damage.

   • According to Yasir Afzal Beigh (2017)

     Excerpt It has a great importance as a folk medicine in ancient history from the time of Greek as an antiseptic, anthelmintic, antipyretic, antimalarial, antioxidant, hepatoprotective & neuroprotective. Artemisia absinthium Linn.

   • According to Ali M (2022)

     Excerpt In this study, antioxidant, antibacterial, & anticancer activities of individual as well as combined 80% ethanolic extracts of Artemisia absinthium leaves & Citrus paradisi peels were investigated. Conclusion: The ethanolic extracts of AA leaves & Citrus paradisi peels can be used against liver cancer because of their antioxidant, antibacterial, & anticancer activities.

   • According to Wei X (2019)

     Excerpt has pharmaceutical & medicinal effects such as antimicrobial, antiparasitic, hepatoprotective, & antioxidant activities. Artemisia absinthium L.

   • According to Szopa A (2020)

     Excerpt Today, numerous other directions of biological activity of the components of this species have been demonstrated & confirmed by scientific research, such as antiprotozoal, antibacterial, antifungal, anti-ulcer, hepatoprotective, anti-inflammatory, immunomodulatory, cytotoxic, analgesic, neuroprotective, anti-depressant, procognitive, neurotrophic, & cell membrane stabilizing and antioxidant activities. Artemisia absinthium—wormwood (Asteraceae)—is a very important species in the history of medicine, formerly described in medieval Europe as “the most important master against all exhaustions”.

2. 2

   Cancer: adjuvant treatment for liver and uterine carcinoma

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2023)

     Excerpt The aim of the present study was to characterize the altered & attenuated gene expression of the selected growth factor namely Transforming growth factor Beta -1 (TGFβ1) & MYC in human hepatoma-derived (Huh7) liver cancer cell lines in response to extracts of Artemisia absinthium dissolved in selected organic solvents. Ethanolic, methanolic & acetone extract of different plant parts (leaf, stem & flowers) was used to access the antiproliferative activity by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay.

   • According to Ali M (2022)

     Excerpt In this study, antioxidant, antibacterial, & anticancer activities of individual as well as combined 80% ethanolic extracts of Artemisia absinthium leaves & Citrus paradisi peels were investigated. Conclusion: The ethanolic extracts of AA leaves & Citrus paradisi peels can be used against liver cancer because of their antioxidant, antibacterial, & anticancer activities.

   • According to Wei X (2019)

     Excerpt Here, we prepared AA ethanol extract (AAEE) & its subfractions including petroleum ether (AAEE-Pe) & ethyl acetate (AAEE-Ea) & investigated their antitumor effect on human hepatoma BEL-7404 cells a&mouse hepatoma H22 cells. Artemisia absinthium L.

   • According to Szopa A (2020)

     Excerpt Today, numerous other directions of biological activity of the components of this species have been demonstrated & confirmed by scientific research, such as antiprotozoal, antibacterial, antifungal, anti-ulcer, hepatoprotective, anti-inflammatory, immunomodulatory, cytotoxic, analgesic, neuroprotective, anti-depressant, procognitive, neurotrophic, & cell membrane stabilizing and antioxidant activities. Artemisia absinthium—wormwood (Asteraceae)—is a very important species in the history of medicine, formerly described in medieval Europe as “the most important master against all exhaustions”.

   • According to Sagástegui-Guarniz WA (2020)

     Excerpt Conclusions: Hepatoprotective & nephroprotective activities of methano& ethyl acetate extract of AA were demonstrated, being methanol extract to 200 mg/kg/day the most effective. Biochemical blood parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea & creatinine, & histopathologic changes of liver & kidney were studied & evaluated.

3. 3

   Bacterial infection: Escherichia coli

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Msaada K (2015)

     Excerpt In addition, total polyphenols, flavonoids, & condensed tannins as well as antioxidant, antibacterial, & antifungal activities of methanolic extract & essential oils were undertaken. Obtained results of antimicrobial activities showed that wormwood essential oil is endowed with important antibacterial activity which was strongly related to the organoleptic quality of oil which appeared strongly region-dependant.

   • According to DO RA (2024)

     Excerpt However, antimicrobial, immunosuppressant, & neuroprotective effects, as well as antifeedant, & nematocidal activities, have been reported for the Artemisia sesquiterpenes. We searched the scientific databases “Scopus”, “PubMed”, & “ISI Web of Science” with the keywords “Artemisia” AND “Sesquiterpene” OR “Sesquiterpenoid” OR “Eudesmanolide” OR “Guaianolide” OR “Germacranolide” OR “Eudesmane” OR “Guaiene” OR “Germacrane”, OR “Chemical”.

   • According to Kordali S (2005)

     Excerpt The antibacterial & antifungal activities of the EOS isolated from A. In general, the oils exhibited potent antifungal activity at a wide spectrum on the growth of agricultural pathogenic fungi.

   • According to Hasan-Nezhad S (2016)

     Excerpt Hasan-Nezhad S et al, Chemical composition & antibacterial activity of essential oil & methanolic extract of Artemisia absinthium L.

   • According to Juteau F (2003)

     Excerpt Juteau F et al, Composition & antimicrobial activity of the essential oil of Artemisia absinthium from Croatia & France.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.