Basella alba (Malabar spinach) : medicinal properties in alcoholic extraction

Basella alba (Malabar spinach, Epinard de Malabar) — family Basellacéess.

Scientific synonyms : Basella cordifolia Lam, B crassifolia Salisb, B japonica Burm.f., B nigra Lour., B ramosa J.Jacq. ex Spreng., B rubra-L.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 59 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Acrylamide-induced hepato- and nephrotoxicity

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Adewale OO (2022)

     Excerpt Basella alba has been reported to have medicinal properties, & in this study, the anti-oxidative potentials of ethanol leaf extract of BA were assessed against oxidative stress induced by acrylamide in male Wistar rats (120-150g). The liver & kidney tissues were processed for the analyses of antioxidant activities.

   • According to Olubayode B (2015)

     Excerpt This work investigated the effect of ethanolic extract of BA on lead- induced hepatotoxicity in male rats. Then, levels of the liver enzymes in the serum were measured.

   • According to Nirmala A (2009)

     Excerpt In liver, the changes caused after induction of diabetes was global microvesicular steatosis .The portal tracts appeared normal & central veins appeared congested, which was brought back to normal after feeding with BR. The diabetes-induced rats were fed with BR(400 mg/100 gm body weight orally through a gavage), when tested after ingestion the fasting blood glucose levels were remarkably reduced to normal & liver glycogen content was remarkably increased.

   • According to Yanadaiah JP (2011)

     Excerpt The aqueous ethanolic extract of aerial parts of BR has shown very significant hepatoprotection against both Paracetamol induced and CCl4-induced hepatotoxicity study models in wistar rats. The present study was conducted to evaluate the hepatoprotective activity of aqueous ethanolic extract of aerial parts of BR in wistar rats.

   • According to Kumar BR (2018)

     Excerpt The evaluation of the cytoxicity of these extracts on A431 (epidermoid carcinoma), Hep G2 (hepatocellular carcinoma) & MG 63 (osteosarcoma) cells indicated anti-proliferative activity against all the cell lines. These studies indicate that Basella sps can be used as a source of natural antioxidants & can be of high significance in pharmaceutical & nutraceutical industries.

2. 2

   Liver cirrhosis, hepatitis, fatty liver disease

   Plant part used: Aerial_parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Adewale OO (2022)

     Excerpt Basella alba has been reported to have medicinal properties, & in this study, the anti-oxidative potentials of ethanol leaf extract of BA were assessed against oxidative stress induced by acrylamide in male Wistar rats (120-150g). The liver & kidney tissues were processed for the analyses of antioxidant activities.

   • According to Yanadaiah JP (2011)

     Excerpt The aqueous ethanolic extract of aerial parts of BR has shown very significant hepatoprotection against both Paracetamol induced and CCl4-induced hepatotoxicity study models in wistar rats. The present study was conducted to evaluate the hepatoprotective activity of aqueous ethanolic extract of aerial parts of BR in wistar rats.

   • According to Olubayode B (2015)

     Excerpt This work investigated the effect of ethanolic extract of BA on lead- induced hepatotoxicity in male rats. Then, levels of the liver enzymes in the serum were measured.

   • According to Kumar BR (2018)

     Excerpt The evaluation of the cytoxicity of these extracts on A431 (epidermoid carcinoma), Hep G2 (hepatocellular carcinoma) & MG 63 (osteosarcoma) cells indicated anti-proliferative activity against all the cell lines. These studies indicate that Basella sps can be used as a source of natural antioxidants & can be of high significance in pharmaceutical & nutraceutical industries.

   • According to Nirmala A (2009)

     Excerpt In liver, the changes caused after induction of diabetes was global microvesicular steatosis .The portal tracts appeared normal & central veins appeared congested, which was brought back to normal after feeding with BR. The diabetes-induced rats were fed with BR(400 mg/100 gm body weight orally through a gavage), when tested after ingestion the fasting blood glucose levels were remarkably reduced to normal & liver glycogen content was remarkably increased.

3. 3

   High blood pressure, fluid retention, oedema var rubra

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kumar V (2011)

     Excerpt In this work the methanolic extract of Basella alba (M.E.B.A.) & aqueous extract of BA were studied for its in-vitro antiinflammatory activities. The aqueous extract showed the most significant membrane stabilizing action on human red blood cell membrane.

   • According to Author (2012)

     Excerpt Basella alba is used in many parts of the world for its medicinal use as laxative, anti-inflammatory, rubefacient, soothing as well as its cooling effects when applied to burns & scalds.

   • According to Deshmukh SK (2014)

     Excerpt Major biological activities exhibited by BA is androgenic, antidiabetic, anti-inflammatory, antimicrobial, antioxidant, antiulcer, antiviral, CNS depressant, hepatoprotective & wound healing, properties.

   • According to RODDA R (2012)

     Excerpt RODDA R et al, INVESTIGATION ON ANTI INFLAMMATORY PROPERTY OF BASELLA ALBA LINN LEAF EXTRACT, Inter J of Pharm & Pharmaceul Sci, 4, :1, 2012,.

   • According to Ashraduzzaman Nur (2023)

     Excerpt alba (native & hybrid) fruit extract & measurement its biological activities like antioxidant, anti-inflammatory, cytotoxic activities & a molecular docking were performed to observed the pharmaceutical impact on the anti-inflammatory Cyclooxygenase-2 (COX-2) enzyme. In anti-inflammatory activity assessment study, the IC50 values of the ethanol extracts were 20.52 ± 0.91 μg/mL for BSA inhibition a 20.43 ± 1.30 μg/mL for RBC hemolytic inhibitory study.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.