Calendula officinalis (Calendula) : medicinal properties in alcoholic extraction

Calendula officinalis (Calendula, Marigold, Souci) — family Asteracées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 128 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Yoshikawa M (2001)

     Excerpt The methanolic extract & its 1-butanol-soluble fraction from the flowers of Calendula officinalis were found to show a hypoglycemic effect, inhibitory activity of gastric emptying, & gastroprotective effect. The principal saponin constituents, glycosides A, B, C, D, & F, exhibited potent inhibitory effects on an increase in serum glucose levels in glucose-loaded rats, gastric emptying in mice, & ethanol- and indomethacin-induced gastric lesions in rats.

   • According to Murakami T (2001)

     Excerpt Following the characterization of hypoglycemic, gastric emptying inhibitory, & gastroprotective principles & the structure elucidation of calendasaponins A, B, C, & D, two new ionone glucosides (officinosides A and B), and two sesquiterpene oligoglycosides (officinosides C & D), were isolated from the flowers of Egyptian Calendula officinalis.

   • According to Silva ER (2007)

     Excerpt The hydroalcohol extract (HAE) of Calendula officinalis L. In the biochemical parameters, there was an increase in blood urea nitrogen (BUN) and in alanine transaminase (ALT) levels.

   • According to Jiménez-Medina E (2006)

     Excerpt In this study, we evaluated the in vitro cytotoxic anti-tumor & immunomodulatory activities & in vivo anti-tumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae). Phytopharmacological studies of different Calendula extracts have shown anti-inflammatory, anti-viral & anti-genotoxic properties of therapeutic interest.

2. 2

   Oropharyngeal mucositis caused by radiotherapy for head and neck cancer

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Babaee N (2016)

     Excerpt This study was designed to determine the effect of Calendula officinalis flowers extract mouthwash as oral gel on radiation-induced oropharyngeal mucositis (OM) in patients with head-and-neck cancer. Forty patients with neck & head cancers under radiotherapy or concurrent chemo-radiotherapy protocols were randomly assigned to receive either 2% calendula extract mouthwash or placebo (20 patients in each group).

   • According to Sak K (2017)

     Excerpt The aim of the present study was to evaluate the potential anticancer action of extracts prepared from German chamomile (Matricaria recutita L.) & pot marigold (Calendula officinalis L.) to human melanoma and epidermoid carcinoma cells. In the present study, the anticancer action of extracts prepared from german chamomile flowers on human melanoma & non-melanoma skin cancer cells (SK-MEL-2 melanoma and KB epidermoid carcinoma cells) is described for the first time.

   • According to Ukiya M (2006)

     Excerpt Ten oleanane-type triterpene glycosides, 1-10, including 4 new compounds, calendulaglycoside A 6'-O-methyl ester (2), calendulaglycoside A 6'-O-n-butyl ester (3), calendulaglycoside B 6'-O-n-butyl ester (5), and calendulaglycoside C 6'-O-n-butyl ester (8), along with five known flavonol glycosides, 11-15, were isolated from the flowers of Calendula officinalis. Furthermore, upon evaluation of the cytotoxic activity against human cancer cell lines in vitro in the NCI Developmental Therapeutics Program, two triterpene glycosides, 9 & 10, exhibited their most potent cytotoxic effects against colon cancer, leukemia, & melanoma cells.

   • According to Jiménez-Medina E (2006)

     Excerpt In this study, we evaluated the in vitro cytotoxic anti-tumor & immunomodulatory activities & in vivo anti-tumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae). Tumor cell lines derived from leukemias, melanomas, fibrosarcomas & cancers of breast, prostate, cervix, lung, pancreas & colorectal were used & tumor cell proliferation in vitro was measured by BrdU incorporation and viable cell count.

   • According to Medina EJ (2006)

     Excerpt Medina EJ et al, A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic antitumor activity & lymphocyte activation.

3. 3

   Cancer: adjuvant treatment for pancreatic carcinoma

   Plant part used: Flower. Mentioned synergistic association: Achillea millefolium-feuille.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mouhid L (2018)

     Excerpt METHODS: In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium & Calendula officinalis) & Lamiaceae (Melissa officinalis & Origanum majorana) plant extracts obtained by different green technologies (Supercritical CO2 Extraction -SFE- & Ultrasonic Assisted Extraction -UAE-) to identify efficient plant extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches. In addition, SFE derived plant extracts from Achillea millefolium & Calendula officinalis displayed synergism with the chemotherapeutic 5-Fluororacil.

   • According to Sak K (2017)

     Excerpt The aim of the present study was to evaluate the potential anticancer action of extracts prepared from German chamomile (Matricaria recutita L.) & pot marigold (Calendula officinalis L.) to human melanoma and epidermoid carcinoma cells. In the present study, the anticancer action of extracts prepared from german chamomile flowers on human melanoma & non-melanoma skin cancer cells (SK-MEL-2 melanoma and KB epidermoid carcinoma cells) is described for the first time.

   • According to Ukiya M (2006)

     Excerpt Ten oleanane-type triterpene glycosides, 1-10, including 4 new compounds, calendulaglycoside A 6'-O-methyl ester (2), calendulaglycoside A 6'-O-n-butyl ester (3), calendulaglycoside B 6'-O-n-butyl ester (5), and calendulaglycoside C 6'-O-n-butyl ester (8), along with five known flavonol glycosides, 11-15, were isolated from the flowers of Calendula officinalis. Furthermore, upon evaluation of the cytotoxic activity against human cancer cell lines in vitro in the NCI Developmental Therapeutics Program, two triterpene glycosides, 9 & 10, exhibited their most potent cytotoxic effects against colon cancer, leukemia, & melanoma cells.

   • According to Gomel de Cédron M (2020)

     Excerpt Herein, we investigate the antitumoral properties and mechanism of action of a supercritical CO2 extract from C officinalis, commonly known as marigold (marigold SFE) in the context of pancreatic cancer. As metabolic reprogramming is a well-recognized hallmark of cancer, the direct impact of marigold SFE on pancreatic cancer cell metabolism encourages further research of its potential as a coadjuvant in pancreatic cancer therapy.

   • According to Jiménez-Medina E (2006)

     Excerpt In this study, we evaluated the in vitro cytotoxic anti-tumor & immunomodulatory activities & in vivo anti-tumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae). Tumor cell lines derived from leukemias, melanomas, fibrosarcomas & cancers of breast, prostate, cervix, lung, pancreas & colorectal were used & tumor cell proliferation in vitro was measured by BrdU incorporation and viable cell count.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.