Calendula officinalis (Calendula) : vertus médicinales en extraction alcoolique

Calendula officinalis (Calendula, Souci, Marigold) — famille Asteracées.

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 11 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 128 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Yoshikawa M (2001)

     Extrait The methanolic extract & its 1-butanol-soluble fraction from the flowers of Calendula officinalis were found to show a hypoglycemic effect, inhibitory activity of gastric emptying, & gastroprotective effect. The principal saponin constituents, glycosides A, B, C, D, & F, exhibited potent inhibitory effects on an increase in serum glucose levels in glucose-loaded rats, gastric emptying in mice, & ethanol- and indomethacin-induced gastric lesions in rats.

   • Selon Murakami T (2001)

     Extrait Following the characterization of hypoglycemic, gastric emptying inhibitory, & gastroprotective principles & the structure elucidation of calendasaponins A, B, C, & D, two new ionone glucosides (officinosides A and B), and two sesquiterpene oligoglycosides (officinosides C & D), were isolated from the flowers of Egyptian Calendula officinalis.

   • Selon Silva ER (2007)

     Extrait The hydroalcohol extract (HAE) of Calendula officinalis L. In the biochemical parameters, there was an increase in blood urea nitrogen (BUN) and in alanine transaminase (ALT) levels.

   • Selon Jiménez-Medina E (2006)

     Extrait In this study, we evaluated the in vitro cytotoxic anti-tumor & immunomodulatory activities & in vivo anti-tumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae). Phytopharmacological studies of different Calendula extracts have shown anti-inflammatory, anti-viral & anti-genotoxic properties of therapeutic interest.

2. 2

   Mucositose oropharyngée induite par la radiothérapie anticancéreuse tête-&-cou

   Partie usitée : Fleur.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Babaee N (2016)

     Extrait This study was designed to determine the effect of Calendula officinalis flowers extract mouthwash as oral gel on radiation-induced oropharyngeal mucositis (OM) in patients with head-and-neck cancer. Forty patients with neck & head cancers under radiotherapy or concurrent chemo-radiotherapy protocols were randomly assigned to receive either 2% calendula extract mouthwash or placebo (20 patients in each group).

   • Selon Sak K (2017)

     Extrait The aim of the present study was to evaluate the potential anticancer action of extracts prepared from German chamomile (Matricaria recutita L.) & pot marigold (Calendula officinalis L.) to human melanoma and epidermoid carcinoma cells. In the present study, the anticancer action of extracts prepared from german chamomile flowers on human melanoma & non-melanoma skin cancer cells (SK-MEL-2 melanoma and KB epidermoid carcinoma cells) is described for the first time.

   • Selon Ukiya M (2006)

     Extrait Ten oleanane-type triterpene glycosides, 1-10, including 4 new compounds, calendulaglycoside A 6'-O-methyl ester (2), calendulaglycoside A 6'-O-n-butyl ester (3), calendulaglycoside B 6'-O-n-butyl ester (5), and calendulaglycoside C 6'-O-n-butyl ester (8), along with five known flavonol glycosides, 11-15, were isolated from the flowers of Calendula officinalis. Furthermore, upon evaluation of the cytotoxic activity against human cancer cell lines in vitro in the NCI Developmental Therapeutics Program, two triterpene glycosides, 9 & 10, exhibited their most potent cytotoxic effects against colon cancer, leukemia, & melanoma cells.

   • Selon Jiménez-Medina E (2006)

     Extrait In this study, we evaluated the in vitro cytotoxic anti-tumor & immunomodulatory activities & in vivo anti-tumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae). Tumor cell lines derived from leukemias, melanomas, fibrosarcomas & cancers of breast, prostate, cervix, lung, pancreas & colorectal were used & tumor cell proliferation in vitro was measured by BrdU incorporation and viable cell count.

   • Selon Medina EJ (2006)

     Extrait Medina EJ et al, A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic antitumor activity & lymphocyte activation.

3. 3

   Cancer : traitement adjuvant du carcinome pancréatique

   Partie usitée : Fleur. Association synergique mentionnée : Achillea millefolium-feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Mouhid L (2018)

     Extrait METHODS: In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium & Calendula officinalis) & Lamiaceae (Melissa officinalis & Origanum majorana) plant extracts obtained by different green technologies (Supercritical CO2 Extraction -SFE- & Ultrasonic Assisted Extraction -UAE-) to identify efficient plant extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches. In addition, SFE derived plant extracts from Achillea millefolium & Calendula officinalis displayed synergism with the chemotherapeutic 5-Fluororacil.

   • Selon Sak K (2017)

     Extrait The aim of the present study was to evaluate the potential anticancer action of extracts prepared from German chamomile (Matricaria recutita L.) & pot marigold (Calendula officinalis L.) to human melanoma and epidermoid carcinoma cells. In the present study, the anticancer action of extracts prepared from german chamomile flowers on human melanoma & non-melanoma skin cancer cells (SK-MEL-2 melanoma and KB epidermoid carcinoma cells) is described for the first time.

   • Selon Ukiya M (2006)

     Extrait Ten oleanane-type triterpene glycosides, 1-10, including 4 new compounds, calendulaglycoside A 6'-O-methyl ester (2), calendulaglycoside A 6'-O-n-butyl ester (3), calendulaglycoside B 6'-O-n-butyl ester (5), and calendulaglycoside C 6'-O-n-butyl ester (8), along with five known flavonol glycosides, 11-15, were isolated from the flowers of Calendula officinalis. Furthermore, upon evaluation of the cytotoxic activity against human cancer cell lines in vitro in the NCI Developmental Therapeutics Program, two triterpene glycosides, 9 & 10, exhibited their most potent cytotoxic effects against colon cancer, leukemia, & melanoma cells.

   • Selon Gomel de Cédron M (2020)

     Extrait Herein, we investigate the antitumoral properties and mechanism of action of a supercritical CO2 extract from C officinalis, commonly known as marigold (marigold SFE) in the context of pancreatic cancer. As metabolic reprogramming is a well-recognized hallmark of cancer, the direct impact of marigold SFE on pancreatic cancer cell metabolism encourages further research of its potential as a coadjuvant in pancreatic cancer therapy.

   • Selon Jiménez-Medina E (2006)

     Extrait In this study, we evaluated the in vitro cytotoxic anti-tumor & immunomodulatory activities & in vivo anti-tumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae). Tumor cell lines derived from leukemias, melanomas, fibrosarcomas & cancers of breast, prostate, cervix, lung, pancreas & colorectal were used & tumor cell proliferation in vitro was measured by BrdU incorporation and viable cell count.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.