Calotropis procera (Bwa-laswa) : medicinal properties in alcoholic extraction

Calotropis procera (Bwa-laswa, Silkwood, Bois-à-soie) — family Asclépiadacées.

Scientific synonyms : Asclepias procera Aiton, Calotropis gigantea-Maycock.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 20 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 122 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Setty RC (2007)

     Excerpt Hydroethanolic extract (70%) of Calotropis procera flowers was prepared and tested for its hepatoprotective effect against paracetamol-induced hepatitis in rats. procera flowers (200 mg/kg and 400 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.

   • According to Parihar G (2011)

     Excerpt The ethanolic extract of root bark of Calotropis procera R.br. The extract of Calotropis procera (CPE) exhibited significant anti-inflammatory effect at the dose 100 and 200 mg/kg.

   • According to Choedon T (2006)

     Excerpt To evaluate the anticancer property of the dried latex (DL) of Calotropis procera, a tropical medicinal plant, in the X15-myc transgenic mouse model of hepatocellular carcinoma & to elucidate its mechanism of action in cell culture. METHODS: The young transgenic mice were orally fed with the aqueous suspension of DL (400 mg/kg for 5 d/wk) for 15 wk and their liver was examined for histopathological changes at 20 wk.

   • According to Murshed M (2023)

     Excerpt The research aimed to assess the efficacy of Calotropis procure leaf extracts on the inhibition of Eimeria stiedae oocysts & to determine the optimal dosage for suppressing the parasite's infective phase. Hepatic coccidiosis is an infectious & mortal disease that causes global economic losses in rabbits.

   • According to Basu A (1992)

     Excerpt Basu A et al, Hepatoprotective effects of Calotropis procera root extract on experimental liver damage in animals.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kazeem MI (2016)

     Excerpt It can be concluded from this study that the C procera extracts could serve as source of antidiabetic agents which may act through the inhibition of carbohydrate hydrolyzing enzymes, α-amylase and α-glucosidase. This study was aimed at evaluating the α-amylase and α-glucosidase inhibitory potential of C procera leaf, as well as its possible mode of inhibiting these enzymes.

   • According to Roy S (2005)

     Excerpt In the present study, dry latex (DL) of Calotropis procera possessing potent anti-inflammatory activity was evaluated for its antioxidant & anti-hyperglycemic effects against alloxan-induced diabetes in rats. DL also produced an increase in the hepatic levels of the endogenous antioxidants, namely superoxide dismutase (SOD), catalase & glutathione, while it brought down the levels of thiobarbituric acid-reactive substances (TBARS) in alloxan-induced diabetic rats.

   • According to Author (2022)

     Excerpt Imosemi I, EVALUATION OF THE TOXICITY, MEDICINAL USE & PHARMACOLOGICAL ACTIONS OF CALOTROPIS PROCERA, Eur J of Pharmaceut & med Res, 3(9):28-36, 2022-A bstract: Calotropis procera also known as the giant milk weed is one of the flowering plants commonly found in the tropic’s world over. procera possesses anti-inflammatory, antibacterial, antipyretic, antidiabetic, anticancer & antioxidant properties.

   • According to Neto MCL (2013)

     Excerpt Neto MCL et al, Evaluation of antihyperglycaemic activity of Calotropis procera leaves extract on streptozotocin-induced diabetes in Wistar rats.

3. 3

   Adjuvant treatment for colorectal carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to BHAGAT M (2010)

     Excerpt In vitro assay for cytotoxic activity of the stem-leaves of Calotropis procera was carried out against human cancer cell lines at the concentration of 10, 30 and 100g/ml. Results revealed that the extracts of the plant possessed in vitro anticancer potential against HCT-15 (colon) cancer cell line at different concentrations.

   • According to Choedon T (2006)

     Excerpt To evaluate the anticancer property of the dried latex (DL) of Calotropis procera, a tropical medicinal plant, in the X15-myc transgenic mouse model of hepatocellular carcinoma & to elucidate its mechanism of action in cell culture. procera has the potential for anticancer therapy due to its differentiable targets and non-interference with regular pathway of apoptosis.

   • According to Arul B (2004)

     Excerpt The antitumor activity of the ethanolic extract of Calotropis procera R. After 14 d of inoculation with DAL cells, ECP is able to reverse the changes in the haematological parameters, protein and packed cellular volume consequent to tumor inoculation.

   • According to Author (2022)

     Excerpt Imosemi I, EVALUATION OF THE TOXICITY, MEDICINAL USE & PHARMACOLOGICAL ACTIONS OF CALOTROPIS PROCERA, Eur J of Pharmaceut & med Res, 3(9):28-36, 2022-A bstract: Calotropis procera also known as the giant milk weed is one of the flowering plants commonly found in the tropic’s world over. procera possesses anti-inflammatory, antibacterial, antipyretic, antidiabetic, anticancer & antioxidant properties.

   • According to Van Quaquebeke E (2005)

     Excerpt Identification of a novel cardenolide (2-oxovoruscharin) from Calotropis procera & the hémi synthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: Structure-activity relationship analyses.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.