Calotropis procera (Bwa-laswa) : propiedades medicinales en extracción alcohólica
Calotropis procera (Bwa-laswa, Madera de seda, Bois-à-soie, Silkwood) — familia Asclépiadacées.
Sinónimos científicos : Asclepias procera Aiton, Calotropis gigantea-Maycock.
Esta base documenta las extracciones alcohólicas (etanol) de las sustancias activas. Nuestra monografía recoge actualmente 22 indicaciones en extracción alcohólica para esta especie. El catálogo Lapo v2 registra 127 referencias científicas para esta especie (detalle completo en la aplicación).
Indicaciones terapéuticas en extracción alcohólica:
Importante — referencias científicas en esta página pública: solo se muestra un breve extracto de cada fuente citada (frases de resumen seleccionadas), conservado en el idioma original de la publicación (casi siempre el inglés), sin traducir. Estos extractos no constituyen el texto íntegro del artículo ni una bibliografía completa. Las fichas de referencia completas y el detalle monográfico están disponibles en la aplicación Lapo v2 (prueba gratuita de 30 días).
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Hepatitis, cirrosis, esteatosis hepática
Références scientifiques (courts extraits)
Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.
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Selon Setty RC (2007)
Extrait Hydroethanolic extract (70%) of Calotropis procera flowers was prepared and tested for its hepatoprotective effect against paracetamol-induced hepatitis in rats. Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, Bilirubin, cholesterol, HDL and tissue GSH were tested in both treated and untreated groups.
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Selon Parihar G (2011)
Extrait The ethanolic extract of root bark of Calotropis procera R.br. The extract of Calotropis procera (CPE) exhibited significant anti-inflammatory effect at the dose 100 and 200 mg/kg.
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Selon Choedon T (2006)
Extrait To evaluate the anticancer property of the dried latex (DL) of Calotropis procera, a tropical medicinal plant, in the X15-myc transgenic mouse model of hepatocellular carcinoma & to elucidate its mechanism of action in cell culture. METHODS: The young transgenic mice were orally fed with the aqueous suspension of DL (400 mg/kg for 5 d/wk) for 15 wk and their liver was examined for histopathological changes at 20 wk.
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Selon Roy S (2005)
Extrait In the present study, dry latex (DL) of Calotropis procera possessing potent anti-inflammatory activity was evaluated for its antioxidant & anti-hyperglycemic effects against alloxan-induced diabetes in rats. DL also produced an increase in the hepatic levels of the endogenous antioxidants, namely superoxide dismutase (SOD), catalase & glutathione, while it brought down the levels of thiobarbituric acid-reactive substances (TBARS) in alloxan-induced diabetic rats.
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Selon Murshed M (2023)
Extrait The research aimed to assess the efficacy of Calotropis procure leaf extracts on the inhibition of Eimeria stiedae oocysts & to determine the optimal dosage for suppressing the parasite's infective phase. Hepatic coccidiosis is an infectious & mortal disease that causes global economic losses in rabbits.
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Selon Setty RC (2007)
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Diabetes mellitus tipo II
Références scientifiques (courts extraits)
Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.
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Selon Kazeem MI (2016)
Extrait It can be concluded from this study that the C procera extracts could serve as source of antidiabetic agents which may act through the inhibition of carbohydrate hydrolyzing enzymes, α-amylase and α-glucosidase. This study was aimed at evaluating the α-amylase and α-glucosidase inhibitory potential of C procera leaf, as well as its possible mode of inhibiting these enzymes.
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Selon Roy S (2005)
Extrait In the present study, dry latex (DL) of Calotropis procera possessing potent anti-inflammatory activity was evaluated for its antioxidant & anti-hyperglycemic effects against alloxan-induced diabetes in rats. DL also produced an increase in the hepatic levels of the endogenous antioxidants, namely superoxide dismutase (SOD), catalase & glutathione, while it brought down the levels of thiobarbituric acid-reactive substances (TBARS) in alloxan-induced diabetic rats.
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Selon Imosemi I (s.d.)
Extrait Imosemi I, EVALUATION OF THE TOXICITY, MEDICINAL USE & PHARMACOLOGICAL ACTIONS OF CALOTROPIS PROCERA, Eur Jl of Pharmaceut & med Res, 3(9):28-36, 2022-A bstract: Calotropis procera also known as the giant milk weed is one of the flowering plants commonly found in the tropic’s world over. procera possesses anti-inflammatory, antibacterial, antipyretic, antidiabetic, anticancer & antioxidant properties.
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Selon Neto MCL (2013)
Extrait Neto MCL et al, Evaluation of antihyperglycaemic activity of Calotropis procera leaves extract on streptozotocin-induced diabetes in Wistar rats.
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Selon Kazeem MI (2016)
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Cáncer: tratamiento adyuvante del carcinoma colorrectal
Références scientifiques (courts extraits)
Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.
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Selon BHAGAT M (2010)
Extrait In vitro assay for cytotoxic activity of the stem-leaves of Calotropis procera was carried out against human cancer cell lines at the concentration of 10, 30 and 100g/ml. Results revealed that the extracts of the plant possessed in vitro anticancer potential against HCT-15 (colon) cancer cell line at different concentrations.
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Selon Choedon T (2006)
Extrait To evaluate the anticancer property of the dried latex (DL) of Calotropis procera, a tropical medicinal plant, in the X15-myc transgenic mouse model of hepatocellular carcinoma & to elucidate its mechanism of action in cell culture. Each fraction was analysed for cytotoxic effect on hepatoma (Huh7) & non-hepatoma (COS-1) cell lines and non-transformed hepatocytes (AML12) using tetrazolium (MTT) assay.
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Selon Arul B (2004)
Extrait The antitumor activity of the ethanolic extract of Calotropis procera R. After 14 d of inoculation with DAL cells, ECP is able to reverse the changes in the haematological parameters, protein and packed cellular volume consequent to tumor inoculation.
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Selon Imosemi I (s.d.)
Extrait procera possesses anti-inflammatory, antibacterial, antipyretic, antidiabetic, anticancer & antioxidant properties. Imosemi I, EVALUATION OF THE TOXICITY, MEDICINAL USE & PHARMACOLOGICAL ACTIONS OF CALOTROPIS PROCERA, Eur Jl of Pharmaceut & med Res, 3(9):28-36, 2022-A bstract: Calotropis procera also known as the giant milk weed is one of the flowering plants commonly found in the tropic’s world over.
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Selon Van Quaquebeke E (2005)
Extrait Identification of a novel cardenolide (2-oxovoruscharin) from Calotropis procera & the hémi synthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: Structure-activity relationship analyses.
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Selon BHAGAT M (2010)
Otras indicaciones (incluidos otros modos de extracción si procede), posologías, precauciones de uso y las <strong>referencias científicas completas</strong> (fichas íntegras, no solo los extractos cortos anteriores) están disponibles en la ficha monográfica de la aplicación Lapo v2.
Evolución de esta ficha pública
Bajo el CTA · historial de cambios públicos
+4 indications · ~7 indicaciónes corregidas · +5 referencias · ~35 referencias corregidas
Solo contadores y dominios: los nombres de indicaciones y sinergias no se listan aquí (abrir la ficha en la aplicación). Los textos de las referencias añadidas, corregidas o retiradas están abajo.
+5 referencias — mostrar textos
NAZIR MM et al, Ethnopharmacological Validation of Calotropis gigantea L. Flower Extract against Rheumatoid Arthritis: Anti-arthritic & immunomodulatory Effects in a CFA-induced Rat Model. ID: 285613105, DOI:10.1016/j.jep.2026.121372, 2026-Abstract: Calotropis gigantea (L.) is traditionally used in South Asian folk medicine for inflammatory disorders, joint pain, & rheumatic conditions. However, its anti-arthritic efficacy has not been systematically validated in an experimental arthritis model. AIM OF THE STUDY: This study investigated the anti-arthritic, antioxidant, & immunomodul…
AñadidaAl-Snafi AE et al, Anticancer effects of Arabian medicinal plants (part 1) - A review. IOSR Jl Of Pharm, 7 (4 -1): 63-102, 2017-Abstract: Many Arabian medicinal plants possessed anticancer activities by many mechanisms as tested by different anticancer tests. These plants included: Adonis aestivalis, Ailanthus altissima, Alhagi maurorum, Allium cepa, Allium sativum, Allium schoenoprasum, Althaea officinalis, Althaea rosea, Ammannia baccifera, Anagyris foetida, Anchusa italica, Antirrhinum majus, Apium graveolens, Arctium Lappa, Aristolochia maurorum, Artemisia campestris, Arundo donax, Ascl…
AñadidaLlaghi M et al, potential role & apoptotic profile of three medicinal plant extracts on Leishmania tropica by MTT assay, macrophage model & flow cytometry analysis, Parasite Epidemiol Control,12: e00201. 2021-Abstract: Treatment of leishmaniasis with conventional synthetic drugs is a major global challenge. This study was designed to explore the leishmanicidal activity & apoptotic profile of three leaf extracts on Leishmania tropica stages. Methods: The plants of Quercus velutina, Calotropis procera & Nicotiana tabacum were gathered from Akbarabad County, in the southeastern part of Kerman …
AñadidaKUMAR A et al, Assessment of Pain-Ameliorative Potential of Ethanolic Extract of Calotropis procera & its Active Components characterization by HPTLC & GC-MS Analysis, Syst Rev Pharm, 13(6):659-64, 2023-Abstract: Calotropis procera is a shrub had been used traditionally for the treatment of many diseases including analgesic, anti-inflammatory, hepatic & other diseases. The flower of the plant has not been investigated for its analgesic activity. The present study aims High Pressure Thin Layer Chromatography (HPTLC) & Gas Chromatography-Mass Spectrometry (GC-MS) analysis of Ethanolic Extract…
AñadidaCavalcante GS et al, Chemical composition & in vitro activity of Calotropis procera (Ait.) latex on Haemonchus contortus, Vet Parasitol, 226 :22-5, 2016-Abstract: Calotropis procera is among the species of medicinal plants that have traditionally been used for the treatment of parasites in small ruminants, stimulating the scientific validation of anthelmintic effects. This study aimed to investigate the chemical composition of ethyl acetate extract of Calotropis procera latex (EAECPL), assess the in vitro effect against Haemonchus contortus and the structural changes caused in the adult wor…
AñadidaRamos MV et al. Involvement of NO in the inhibitory effect of Calotropis procera latex protein fraction on leukocyte Rollin, adhesion & infiltration in rat peritonitis model, Jl Ethnopharmacol, 125 (3):387-92, 2009.
CorregidaSoares PM et al, Anti-nociceptive activity of Calotropis procera latex in mice. Jl Ethnopharm 99:125–9, 2005.-Abstract: This work evaluated the antinociceptive effect of proteins from the C procera latex using three different experimental models of nociception in mice. The latex protein fraction administered intraperitoneally in male mice at the doses of 12.5, 25 and 50 mg/kg showed the antinociceptive effect in a dose dependent manner compared to the respective controls in all assays. Inhibitions of the acetic acid-induced abdominal constrictions were observed at the doses of 12.5 (67.9%),…
CorregidaSharma M et al, Evaluation of antibacterial activity of C. gigantica against Streptococcus mutans & Lactobacillus acidophilus: An in vitro comparative study. Jl Conserv Dent. 2015;18(6):457-60.
CorregidaSABA AB et al, Antiinflammatory & analgesic activities of ethanol leaves extract of Calotropis procera, Afr Jl of Biomed Res, 14 :203-8, 2011.-Abstract: Ethanolic extract of the leaf of Calotropis procera was investigated for its anti-inflammatory & analgesic activities. The extract was evaluated using formalin-induced paw lick, carrageenan-induced paw oedema in Wistar rats, acetic acid-induced writhing & tail flick tests in mice. Each experiment consisted of thirty animals randomly, but equally divided into groups of 100mg/kg, 200mg/kg or 400mg/kg body weight (b.w) of extract, Indomethacin…
CorregidaSingh H et al. Inflammation induced by latex of Calotropis procera—a new model to evaluate anti-inflammatory drugs. Jl Pharmacol Toxicol Methods. 2000; 43(3):219–24.
CorregidaSundaram S et al, In Vitro Cytotoxic Activity of Indian medicinal plants used traditionally to treat cancer. Asian Jl of Pharmaceut & Clin Res, 2011;4(1)-Abstract: The SRB assay was used to test in vitro cytotoxicity against four human cancer cell lines of six Indian medicinal plant species which are being used by traditional people in tribal regions for the treatment of ulcers & other diseases of patients. The ethanolic & aqueous extracts were tested against human cancer cell lines such as human neuroblastoma cell line (IMR-32) & colon cell lines (HT-15 & HT-29) & lung cancer cell lines A-…
CorregidaSharma P et al, Evaluation of in-vitro schizonticidal activity of plant parts Calotropis procera-an ethnobotanical approach. Jl of Ethnopharmacol. 1999; 68(1-3): 83-95.
CorregidaShukla OP et al, Properties & partial purification of bacteriolytic enzyme from the latex of Calotropis procera (Madar). Jl of Sci & Industry Res, 1961; 20C: 109-12.
CorregidaUSMAN A et al, ISOLATION OF DIHYDROQUERCETIN GLYCOSIDE FROM THE ROOT BARK OF CALOTROPIS PROCERA & ANTIOXIDANT & CYTOTOXIC SCREENING OF THE CRUDE EXTRACTS., Jl of CHEM Soc of Nigeria, 46:1, 2021-Abstract: The root bark of Calotropis procera (Family: Asclepiadaceae) was extracted with methanol. The methanolic extract was separated into hexane, chloroform, ethyl acetate, & water-soluble fractions. The ethyl acetate fraction was subjected to Bioassay-guided fractionation & final purification was achieved by column chromatography. The structure of the compound was elucidated by spectroscopic met…
CorregidaVelmurugan S et al, antimicrobial effect of Calotropis procera active principles against aquatic microbial pathogens isolated from shrimp & fishes. Asian Pac Jl of Trop Biomed. 2012; 2(2): S812-7.
CorregidaTABASSUM A et al, Phytochemical’s screening and free radical scavenging potential of leaf and flower extract of Calotropis procera, Jl of Pharmacogn & Phytochem, 5(5):47-50, 2016.-Abstract: The aim of the present study was to evaluate the phytochemical constituents and to assess in vitro lipid peroxidation inhibitions & antioxidant activities of different fractions of dried leaves & flowers of Calotropis procera. Qualitative analysis of phytochemicals constituent like steroids, saponin, flavonoid, tannin, coumarin, terpenoids & cardiac glycosides was performed by the well-known tests protoc…
CorregidaTsala DE et al, Evaluation of the antioxidant activity & the healing action of the ethanol extract of Calotropis procera bark against surgical wounds. Jl Intercult Ethnopharmacol. 2015;4(1):64-9-Abstract: The objective of the present study was to evaluate the antioxidant potential and the wound healing effect of the ethanolic extract of the bark of C procera. The antioxidant study was evaluated in vitro, using 2,2-diphenylpicrylhydrazyl (DPPH) and deoxyribose degradation assays. Wound healing was studied using excision and incision wound on normal & Dexamethasone-suppressed wound healing ro…
CorregidaAbdelkader AB et al, Antiandrogenic activity of Calotropis procera latex in rats. Asian Pac Jl Reprod 2018; 7:129-35-Abstract: To determine the effects of Calotropis procera latex on pubertal traits of immature male Wistar rats. Methods: A total of 30 immature male Wistar rats aged 3 weeks old were grouped randomly into 5 groups: group A (control group) was offered distilled water as a placebo; group B was daily oral dosed with suspension of CP latex at a dose rate of 5 mg/kg BW, group C 10 mg/kg BW; group D 15 mg/kg BW & group E 20 mg/ kg BW. The rats were weighed daily to adjust the dose …
CorregidaAl-Rowaily SL et al, Essential Oil of Calotropis procera: Comparative Chemical Profiles, Antimicrobial Activity, & Allelopathic Potential on Weeds, Mol 25(2)1:5203-2020-Abstract: the present study aimed to compare the chemical profiles of the EOs of the widely distributed medicinal plant Calotropis procera collected from Saudi Arabia & Egypt. In addition, this study also aimed to assess their allelopathic & antimicrobial activities. The EOs from Egyptian & Saudi ecospecies were extracted by hydrodistillation & analyzed via GC-MS. The correlation between the analyzed EOs & those published f…
CorregidaJalalpure SS. Anticonvulsant effects of Calotropis procera root in rats. Pharmaceut Biol, 2009; 47(2): 162-7.-Abstract: present study investigated the anticonvulsant activity of different root extracts of Calotropis procera R. Br. (Asclepiadaceae) in rats in order to evaluate the traditional use of this plant. The anticonvulsant activity of different extracts of C procera roots was studied against seizures induced by maximal electroshock seizures (MES), pentylenetetrazol (PTZ), lithium-pilocarpine & electrical kindling seizures. In the MES test, the chloroform extract of C procera roots sho…
CorregidaToson ESA et al, toxic & anti-fertility effects of Alocasia macrorrhiza & Calotropis procera ethanolic extracts on male mice, Inter Jl of Biochem, 2014, 328- 38-Abstract: This study presents Alocasia macrorrhiza & Calotropis procera plants extracts as a potential substitute to the chemical rodenticides. Therefore, the toxic effects of the crude ethanolic extracts of their leaves on liver, kidney & testis of male Albino mice were investigated using different biochemical & histopathological examinations. The results indicated that both leaf extracts, administered in a high dose (1/5 of the L…
CorregidaDevasari T. Toxic effects of Calotropis procera. Indian J Pharmacol. 1965; 27: 272–5.
CorregidaKhuarana SMP. Studies on Calotropis procera latex as an inhibitor of Tobacco mosaic virus, Phytopathology. 1972; 73: 341.
CorregidaMoursy L.E. Insecticidal activity of Calotropis procera extracts of the Flesh Fly, Sarcophaga haemorrhoidalis Fallen. J of the Egyptian Society of Parasitology, 27(2) :505-514, 1997.-Abstract: The Insecticidal activity, expressed by LD50 values, of acetone, ethanol, petroleum ether and water extracts of Calotropis procera leaves against the Flesh Fly, Sarcophaga haemorrhoidalis Fallen was evaluated in the Laboratory. Based on LD50 values, ethanol extract was nearly 1.7, 1.3 and 1.3 times more toxic to larvae than water, petroleum ether and acetone extracts, respectively. It was 1.9, 1.4 and…
CorregidaEdman ED. Nutrient & Cardenolide composition of un-extracted and solvent extracted Calotropis procera. Jl of Agric & Food Chem. 1983; 31(3): 509-13.
CorregidaKumar VL et al, Anti-inflammatory activity of the latex of Calotropis procera. Jl of Ethnopharm, 1994; 123-5.
CorregidaMueen Ahmed KK, Rana AC, Dixit VK. Studies on Calotropis species for antimyocardial infarction activity in albino rats. Indian drugs, 2002; 39(11): 613-5.
CorregidaRoy S et al. Antioxidant & Protective effect of Latex of Calotropis procera against alloxan-induced diabetes in rats. JL of Ethnopharmacology. 2005; 102(3): 470-3-Abstract: In the present study, dry latex (DL) of Calotropis procera possessing potent anti-inflammatory activity was evaluated for its antioxidant & anti-hyperglycemic effects against alloxan-induced diabetes in rats. Daily oral administration of DL at 100 & 400 mg/kg doses produced a dose-dependent decrease in the blood glucose & increase in the hepatic glycogen content. DL also prevented the loss of body weight in diabetic rats…
CorregidaSeddek ALS et al. Extract from Calotropis procera latex activated murine macrophages, Jl Nat Med, 63:297-303, 2009.
CorregidaImosemi I, EVALUATION OF THE TOXICITY, MEDICINAL USE & PHARMACOLOGICAL ACTIONS OF CALOTROPIS PROCERA, Eur Jl of Pharmaceut & med Res, 3(9):28-36, 2022-A bstract: Calotropis procera also known as the giant milk weed is one of the flowering plants commonly found in the tropic’s world over. It is known as Sodom apple, calotrope, French cotton, small crown flower (English) & algodón de seda, bomba (Spanish). The plant is used as arrow poison & the latex is toxic to the skin and poisonous to the eyes, which can lead to blindness. Inspire of the toxicity of C. procera, it has been used in tradi…
CorregidaDhawan BN et al, Evaluation of some indigenous drugs for stimulant effect on rat uterus: A preliminary report. Indian Jll of Medical Res, 1958; 46: 808.
CorregidaRasik M et al, Healing potential of Calotropis procera on dermal wounds in Guinea pigs, Jl. Ethnopharmacol. 1999; 68(1-3): 261-6.
CorregidaSingh N et al, Antiplasmodial activity of medicinal plants from Chhotanagpur plateau, Jharkhand, India. Jl Ethnopharm. 2015; 13:152-62.
CorregidaTour N et al. Anti-inflammatory & gastromucosal protective effects of Calotropis procera (Asclepiadaceae) stem bark. Jl Nat Med. 2011;65(3-4):598-605.-Abstract: This study was aimed at evaluating the anti-inflammatory and gastromucosal protective effect of chloroform extract (CH) and hydroalcoholic extract (HE) of the stem bark of Calotropis procera obtained successively by cold maceration. The anti-inflammatory effect of the CH & HE extracts of the stem bark of CP against carrageenan-induced paw oedema & also its gastromucosal protective effect has been studied by using two acute models: A…
CorregidaJaliwala YA et al, Pharmacological evaluation of antitussive, antiasthmatic and expectorant activities of Calotropis gigantea R.Br. in experimental animals. Jl Pharma Res 2011; 4(10):3383-5.
CorregidaIbrahim S.R.M et al, New ursane-type triterpenes from the root bark of Calotropis procera. Asian Pacific Jl of Tropical Biomed, 2012;2(2): S812-7.
CorregidaNenaah G. Antimicrobial activity of Calotropis procera Ait. (Asclepiadaceae) & isolation of four flavonoid glycosides as the active constituents. World J Microbiol Biotech. 2013;29(7):1255–62.
CorregidaAHMED OM et al, Cardiac & testicular toxicity effects of the latex & ethanolic leaf extract of Calotropis procera on male albino rats in comparison to Abamectin, Springer-plus. 2016; 5(1): 1644.-Abstract: The present study aims to assess the toxic effect of latex & ethanolic leaf extract of Calotropis procera in comparison to Abamectin, on serum biomarkers of function & histological integrity of heart & testis in male albino rats. To achieve this aim, the albino rats were separately administered 1/20 & 1/10 of LD50 of C. procera latex, ethanolic C. procera leaf extract & Abamectin respectiv…
CorregidaKuriachen PM, Dave Y. Structural, developmental and histochemical studies in the collectors of Calotropis procera (Asclepiadaceae) J Phytol Res. 1989; 2: 7–14.
CorregidaRamos MV et al, Latex constituents from Calotropis procera (R. Br.) display toxicity upon egg hatching & larvae of Aedes aegypti (Linn.). Mem Inst Oswaldo Cruz, Rio de Janeiro; 101(5): 503-100, 2006-ABSTRACT: Calotropis procera R. Br. (Asclepiadaceae) is a well-known medicinal plant with leaves, roots, & bark being exploited by popular medicine to fight many human & animal diseases. This work deals with the fractionation of the crude latex produced by the green parts of the plant & aims to evaluate its toxic effects upon egg hatching & larval development of Aedes aegypti. The whole latex wa…
Corregida