Centella asiatica (Ich-tig) : medicinal properties in alcoholic extraction

Centella asiatica (Ich-tig, Lavéronik, Zèb-poul-bwa, Tiger-child, Véronique, Wood-nettle, Enfant-de-tigre, Herbe-à-poux-de bois) — family Apiacées.

Scientific synonyms : Hydrocotyle asiatica-L.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 40 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 224 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Glibenclamide-induced nephropathy

   Plant part used: leaf. Mentioned synergistic association: association synergique avec PLUMERIA RUBRA-L (Fleur), ASPARAGUS RACEMOSUS-Willd.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Yadav AV (2022)

     Excerpt The current investigation analysed the effect of combination of standardized hydroalcoholic extracts of Asparagus racemosus (AR), Centella asiatica (CA)& Plumeria rubra (PR) on glibenclamide (GB) administered in experimentally induced diabetic nephropathy (DN) in Wistar rats. Co-administration of ACP (400mg/kg) with GB (5mg/kg) significantly (p<0.01) decreased BUN, creatinine, uric acid, significantly increased (p<0.05) SOD, significantly (p<0.01) decreased MDA, significantly increased (p<0.05) serum insulin when compared with diabetic control.

   • According to Venu Gopal Rao ML (2007)

     Excerpt Venu Gopal Rao ML et al Antidiabetic effects of methanolic extract of Centella asiatica (Linn.) on induced hyperglycemic rats.

   • According to Chauhan PK (2010)

     Excerpt The ethanolic & methanolic extracts of the leaves of Centella asiatica (Family-Umbelliferae) were tested for antidiabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. In long term treatment of alloxan induced diabetic rats, the degree of protection was determined by measuring blood glucose, triglycerides, cholesterol and urea levels on 0, 3, 5, 7 and 10th day.

   • According to Lindawati NY (2014)

     Excerpt The research aims to see the effect of combination from purified extract of AP herb & CA of translocation of GLUT-4 protein in model type 2 diabetes mellitus rats-insulin resistance compared with the use of each purified extract. Determination of insulin resistance used 3 parameters such as blood glucose levels, lipid levels (triglycerides, LDL, cholesterol, & HDL), & hypoglycemic tests with Glibenclamide compared to normal controls animals.

   • According to Wang L (2024)

     Excerpt This study aims to design & develop a PLX/ZnO nanocomposite incorporated with Centella Asiatica extract (CAE) for the multi-functional action in the diabetic wound healing treatment. Diabetic wounds can occur as a prevalent complication among people diagnosed with diabetes, frequently resulting in the necessity for amputation.

2. 2

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lindawati NY (2014)

     Excerpt The research aims to see the effect of combination from purified extract of AP herb & CA of translocation of GLUT-4 protein in model type 2 diabetes mellitus rats-insulin resistance compared with the use of each purified extract. Determination of insulin resistance used 3 parameters such as blood glucose levels, lipid levels (triglycerides, LDL, cholesterol, & HDL), & hypoglycemic tests with Glibenclamide compared to normal controls animals.

   • According to Yadav AV (2022)

     Excerpt The current investigation analysed the effect of combination of standardized hydroalcoholic extracts of Asparagus racemosus (AR), Centella asiatica (CA)& Plumeria rubra (PR) on glibenclamide (GB) administered in experimentally induced diabetic nephropathy (DN) in Wistar rats. Co-administration of ACP (400mg/kg) with GB (5mg/kg) significantly (p<0.01) decreased BUN, creatinine, uric acid, significantly increased (p<0.05) SOD, significantly (p<0.01) decreased MDA, significantly increased (p<0.05) serum insulin when compared with diabetic control.

   • According to Chauhan PK (2010)

     Excerpt The ethanolic & methanolic extracts of the leaves of Centella asiatica (Family-Umbelliferae) were tested for antidiabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. In long term treatment of alloxan induced diabetic rats, the degree of protection was determined by measuring blood glucose, triglycerides, cholesterol and urea levels on 0, 3, 5, 7 and 10th day.

   • According to Wang L (2024)

     Excerpt This study aims to design & develop a PLX/ZnO nanocomposite incorporated with Centella Asiatica extract (CAE) for the multi-functional action in the diabetic wound healing treatment. Diabetic wounds can occur as a prevalent complication among people diagnosed with diabetes, frequently resulting in the necessity for amputation.

   • According to LIU YQ (2022)

     Excerpt Diabetic cutaneous ulcers (DCU) are a chronic and refractory complication of diabetes mellitus, which can lead to amputation or even death in extreme cases. Centella asiatica total glycosides are extracted from the traditional Chinese medicine Centella asiatica & have angiogenic, anticancer, antioxidant, &wound healing effects.

3. 3

   Liver conditions; cirrhosis, hepatitis, fatty liver: Vitis

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Munakarmi S (2023)

     Excerpt Liver injury can be acute or chronic, resulting from a variety of factors, including viral hepatitis, drug overdose, idiosyncratic drug reaction, or toxins, while the progression of pathogenesis in the liver rises due to the involvement of numerous cytokines & growth factor mediators. Collectively, VCEC exhibited synergistic protective effects against liver injury through its antioxidant, anti-inflammatory, & antiapoptotic ability against oxidative stress, inflammation, & apoptosis.

   • According to Darnis F (1979)

     Excerpt Use of à Titrated extract of Centella asiatica in chronic hepatic disorders.

   • According to PARK DW (2020)

     Excerpt We conducted this study to determine the potential of Centella asiatica as a natural substance to protect against APAP-induced liver injury. However, mice treated with C.A 50% ethanol extract (CA-HE50, 200 mg/kg) for a week before induction of hepatotoxicity by APAP had similar liver weights to those of mice in which hepatotoxicity was not induced.

   • According to HONG W (2021)

     Excerpt In a previous study, we revealed the protective effect of Centella asiatica 50% ethanol extract (CA-HE50) on acetaminophen-induced liver injury. In the present study, we investigate the hepatoprotective effect of CA-HE50 in a lipopolysaccharide /galactosamine (LPS-D-Gal)-induced ALF animal model & compare it to existing therapeutic silymarin, Lentinus edodes mycelia (LEM) extracts, ursodeoxycholic acid (UDCA) & dimethyl diphenyl bicarboxylate (DDB).

   • According to Ghosh K (2017)

     Excerpt The present study was designed to examine the protective effect of Centella asiatica ethanolic leaves extract on the haematological, hepatic & nephritic function marker changes induced in the blood of cadmium chloride treated albino rats. Various concentrations of C asiatica ethanolic extract (20, 40, 60, 80, 100 mg/kg body weight) or silymarin (50 mg/kg body weight) as a pretreatment were administered for 30 days to rats treated with cadmium chloride (5 mg/kg body weight).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.