Cnidoscolus chayamansa (Lachaya) : medicinal properties in alcoholic extraction

Cnidoscolus chayamansa (Lachaya) — family Euphorbiacées.

Scientific synonyms : C. aconitifolius-(Mill)-Johnston.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 47 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Echeverria-Bobadilla F (2014)

     Excerpt Cnidoscolus chayamansa, is an endemic plant from the Southeastern of Mexico known for its easy & cheap growing requirements. chayamansa contains dihydro-myricetin a flavonoid that is believed exerts Hypoglycemic effects.

   • According to Manzanilla Valdez MZ (2021)

     Excerpt Hypotensive effect, glucose tolerance curve & hypoglycaemic effect was evaluated in rats induced to obesity, hyperglycemia & hypertension. The aim of this study was to evaluate hypotensive & hypoglycemic effect of six Chaya leaves extracts (aqueous, ethanolic, acetone, ethyl acetate, diethyl ether & hexane).

   • According to Oyagbemi AA (2010)

     Excerpt This research was designed to investigate the antidiabetic properties of ethanolic extract of Cnidoscolus aconitifolius in alloxan-induced diabetes mellitus in Wistar male albino rats. From this study, CA extract was found to considerably reduce blood glucose & plasma cholesterol levels & progressively increase weight gain in diabetic treated rats confirming its traditional use for the treatment of diabetes.

   • According to García-Rodríguez RV (2014)

     Excerpt CC is also used as a traditional remedy for the treatment of diabetes, rheumatism, gastrointestinal disorders a& inflammation-related diseases. C chayamansa Mc V (Euphorbiaceae) is commonly known as 'Chaya' in Central America.

   • According to IWUJI SC (2014)

     Excerpt This study investigated the blood glucose lowering efficacy of the chloroform fraction of hydromethanolic leaf extract of Cnidoscolus aconitifolius (CA) compared with Glibenclamide in alloxan-induced diabetic Wistar rats. Effective dose of CA could prevent the rapid hypoglycaemic side effect in glibenclamide usage.

2. 2

   Hepatitis, fatty liver, cirrhosis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pillai KK (2012)

     Excerpt Administration of ethanolic extracts of Cnidoscolus chayamansa significantly prevented Rifampicin-Isoniazid-induced elevation in the levels of serum diagnostic liver marker enzymes aspartate amino transferase (AST), alanine amino transferase (ALT) & alkaline phosphatase (ALP) level in experimental groups of rats. The effect of ethanolic extract of Cnidoscolus chayamansa (Family of Euphorbiaceae) leaves in experimentally drug induced hepatitis in rats.

   • According to Quintal-Martinez JP (2021)

     Excerpt In Mexico, Cnidoscolus aconitifolius (Chaya) has been used to treat cardiovascular diseases (CVD).

   • According to Pillai K (2012)

     Excerpt The normalization of these effects observed in the serum treated with EECC possesses significant antitumor & hepatoprotective effect of the extracts. Plants of Chayamansa were traditionally used in the treatment of tumors.

   • According to Manzanilla-Valdès ML (2021)

     Excerpt Aqueous, ethanolic, methanolic, & ethyl acetate extracts of Cnidoscolus aconitifolius have shown nephroprotective & hepatoprotective potential & can be an alternative to prevent & treat CKD & LD. Chaya extracts are no toxic for renal & hepatic cells,.

   • According to Pillai KK (2012)

     Excerpt in India the decoction of Chaya (Cnidoscolus chayamansa) is used as a house hold remedies for diabetics. The alteration in hepatic glycogen content & hepatic glucokinase, hexokinase a&glucose-6-phosphate levels in diabetic rats were partially restored by Ethanolic extracts of CC.

3. 3

   Arthritis, osteoarthritis, rheumatism

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to García-Rodríguez RV (2014)

     Excerpt When tested for their antioxidant activity none of the extracts showed a significant activity suggesting that the anti-inflammatory activity is not related to a direct free radical scavenging of the extracts. RESULTS: The results showed a similar anti-inflammatory activity (≈30%) for all extracts but only the EtOAc extract showed relevant activity when applied intraperitoneally.

   • According to Onasanwo SA (2011)

     Excerpt METHODS: The analgesic activity of the extract was assayed by the formalin-induced paw licking test, acetic acid-induced abdominal writhing & hot plate test, whereas its anti-inflammatory activity was determined by its effects on carrageenan-induced paw edema. Ethanolic leaf extract of Cnidoscolus aconitifolius was evaluated for analgesic & anti-inflammatory activities.

   • According to Perez-Gonzalez MZ (2018)

     Excerpt chayamansa leaves & pure compounds (moretenol, moretenyl acetate, kaempferol-3,7-dimethyl ether, and 5-hydroxy-7-3',4'-trimethoxyflavanone) showed important topical and systemic anti-inflammatory activity in acute model, as well as in vitro antimycobacterial & antiprotozoal activities. In this paper, we describe the in vivo hepatoprotective & anti-inflammatory effects of the CHCl3: MeOH extract in chronic model and the isolation of additional compounds (moretenone & lupeol acetate).

   • According to Mena Y (2015)

     Excerpt Traditionally, it is used for diabetes, obesity, arthritis & anti-inflammatory in several disturbances associated to inflammatory processes. The specie Cnidoscolus chayamansa is an important nutritive source because of its high percent of proteins & minerals.

   • According to Us-Medina U (2020)

     Excerpt The ETOH extract had the highest anti-inflammatory activity, decreasing gene expression for TNF- by 39.78% & for IL-6 by 97.81%, & their production by 46% & 48.38%, respectively, in macrophages stimulated with LPS. Secondary metabolites from plant sources such as Cnidoscolus aconitifolius may be used as adjuvants in the prevention of diseases related to oxidative stress & inflammation such as NCDs.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.