Cnidoscolus chayamansa (Lachaya) : medicinal properties in alcoholic extraction

Cnidoscolus chayamansa (Lachaya) — family Euphorbiacées.

Scientific synonyms : C. aconitifolius-(Mill)-Johnston.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 46 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Echeverria-Bobadilla F (2014)

     Excerpt Cnidoscolus chayamansa, is an endemic plant from the Southeastern of Mexico known for its easy & cheap growing requirements. chayamansa contains dihydro-myricetin a flavonoid that is believed exerts Hypoglycemic effects.

   • According to Oyagbemi AA (2010)

     Excerpt This research was designed to investigate the antidiabetic properties of ethanolic extract of Cnidoscolus aconitifolius in alloxan-induced diabetes mellitus in Wistar male albino rats. From this study, CA extract was found to considerably reduce blood glucose & plasma cholesterol levels & progressively increase weight gain in diabetic treated rats confirming its traditional use for the treatment of diabetes.

   • According to García-Rodríguez RV (2014)

     Excerpt CC is also used as a traditional remedy for the treatment of diabetes, rheumatism, gastrointestinal disorders a& inflammation-related diseases. C chayamansa Mc V (Euphorbiaceae) is commonly known as 'Chaya' in Central America.

   • According to IWUJI SC (2014)

     Excerpt This study investigated the blood glucose lowering efficacy of the chloroform fraction of hydromethanolic leaf extract of Cnidoscolus aconitifolius (CA) compared with Glibenclamide in alloxan-induced diabetic Wistar rats. Effective dose of CA could prevent the rapid hypoglycaemic side effect in glibenclamide usage.

   • According to Roy DN (2016)

     Excerpt This study is aimed at investigating the phytocomponents & hypoglycemic effect of ethanolic leaf extract of CA in streptozotocin induced-diabetic mice. Hypoglycemic effect was investigated in streptozotocin-induced diabetic mice and a dose dependent reduction in blood glucose level was found to have with huge reduction at a dose of 200 mg/kg from 245.33±13.01 (mg/dl) to 187.03±7.19 (mg/dl) after intraperitoneal administration (p<0.05) of extract.

2. 2

   Hepatitis, fatty liver, cirrhosis

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pillai KK (2012)

     Excerpt Administration of ethanolic extracts of Cnidoscolus chayamansa significantly prevented Rifampicin-Isoniazid-induced elevation in the levels of serum diagnostic liver marker enzymes aspartate amino transferase (AST), alanine amino transferase (ALT) & alkaline phosphatase (ALP) level in experimental groups of rats. The effect of ethanolic extract of Cnidoscolus chayamansa (Family of Euphorbiaceae) leaves in experimentally drug induced hepatitis in rats.

   • According to Quintal-Martinez JP (2021)

     Excerpt In Mexico, Cnidoscolus aconitifolius (Chaya) has been used to treat cardiovascular diseases (CVD).

   • According to Pillai K (2012)

     Excerpt The normalization of these effects observed in the serum treated with EECC possesses significant antitumor & hepatoprotective effect of the extracts. Plants of Chayamansa were traditionally used in the treatment of tumors.

   • According to Manzanilla-Valdès ML (2021)

     Excerpt Aqueous, ethanolic, methanolic, & ethyl acetate extracts of Cnidoscolus aconitifolius have shown nephroprotective & hepatoprotective potential & can be an alternative to prevent & treat CKD & LD. Chaya extracts are no toxic for renal & hepatic cells,.

   • According to Pillai KK (2012)

     Excerpt in India the decoction of Chaya (Cnidoscolus chayamansa) is used as a house hold remedies for diabetics. The alteration in hepatic glycogen content & hepatic glucokinase, hexokinase a&glucose-6-phosphate levels in diabetic rats were partially restored by Ethanolic extracts of CC.

3. 3

   Cancer: adjuvant treatment for ascites carcinoma

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pillai K (2012)

     Excerpt The present investigation was carried out to evaluate the antitumor activity of Ethanolic extracts of CC in DLA tumor bearing mice. The EECC treated animals at the doses of 200 & 400 mg/kg significantly inhibited the tumor volume, packed cell volume, tumor (viable) cell count and brought back the hematological parameters to more or less normal levels.

   • According to Pillai K (2012)

     Excerpt Ethanolic Extract of Cnidoscolus chayamansa (EECC) has been used in traditional & folklore medicine for the treatment of cancer. The aim of the present study was to evaluate the effect of Ethanolic Extract of leaves of C chayamansa (EECC) against intraperitoneally injected Dalton's Ascitic Lymphoma (DAL) cell lines in Swiss albino mice.

   • According to Pillai K (2014)

     Excerpt The present study was performed experimentally by Invitro method to examine the anti-cancer activity at various concentration (62.5μg/ml - 1000 μg/ml) of ethanolic extract of the leaves of Cnidoscolus chayamansa against HT-29 (Colon Carcinoma) cell lines using MTT assay method. The anticancer properties of Cnidoscolus chayamansa will provide useful information in the possible application in the treatment of neoplastic therapy & prevention.

   • According to Periyar Maniammai (n.d.)

     Excerpt Chayamansa at high dose & low dose exhibited significant anti-hyperglemic activity in normal & alloxan-diabetic rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.