Conyza bonariensis (Zèb-Kodenn) : medicinal properties in alcoholic extraction

Conyza bonariensis (Zèb-Kodenn, Indian cock’s-foot, herbe-à-coq d’Inde, hierba de gallo de la India) — family Asteracées.

Scientific synonyms : Erigeron bonariensis-L, Leptilon bonariense-(L)-Small..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 6 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 35 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Akhtar MF (2021)

     Excerpt The plant extract (250 & 500mg/kg/day) was explored for its anti-hyperglycemic effect for 14 days in normoglycemic & alloxan-induced diabetic rats using the oral glucose tolerance test (OGTT). To evaluate the anti-diabetic potential of aqueous methanolic extract of Conyza bonariensis amongst the Wistar rats.

   • According to MUSTAFA I (2024)

     Excerpt Total oxidant status (TOS) and the serum glucose levels of the streptozotocin-treated rats were reduced significantly (P ⩽ .05) in Conyza bonariensis treated group. This study was conducted to assess the possible antidiabetic potential of Conyza bonariensis by employing in vitro as well as in vivo assessments.

   • According to Saleem M (2021)

     Excerpt The plant extract (250 a&500mg/kg/day) was explored for its anti-hyperglycemic effect for 14 days in normoglycemic & alloxan-induced diabetic rats using the oral glucose tolerance test (OGTT). To evaluate the anti-diabetic potential of aqueous methanolic extract of Conyza bonariensis amongst the Wistar rats.

   • According to AL-KAZMAN BSM (2025)

     Excerpt Conyza bonariensis (CB), a traditional medicinal plant, has demonstrated antioxidant, anti-inflammatory, and hepatoprotective properties, making it a promising candidate for NAFLD therapy. Non-alcoholic fatty liver disease (NAFLD) is a rising global health concern closely linked with obesity, insulin resistance, and metabolic syndrome.

2. 2

   Cancer: adjuvant treatment of liver and breast cancer

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Saleem M (2014)

     Excerpt The hepatoprotective activity of Conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The results showed that an extract of C.B (250 mg/kg & 500 mg/kg) produced (p<0.05) decline in paracetamol induced liver marker enzymes & total bilirubin, but its 750 mg/kg showed remarkable decline in ALT, AST, ALP & TB levels, compared to the reference levels of silymarin & results were supported by histopathology of liver section.

   • According to AL-KAZMAN BSM (2025)

     Excerpt In vivo, extract-treated groups showed significant improvement in liver function tests, lipid profiles, and oxidative stress markers (p < 0.05), with the highest dose group (750 mg/kg) displaying histologically reduced hepatic steatosis and inflammation. Conyza bonariensis (CB), a traditional medicinal plant, has demonstrated antioxidant, anti-inflammatory, and hepatoprotective properties, making it a promising candidate for NAFLD therapy.

   • According to BATOOL S (2025)

     Excerpt The leaf extract, showing the most promising anticancer activity, was further analyzed against liver cancer cells, yielding an IC50 value of 1.72 μg mL−1. These compounds, primarily the leaf extract, demonstrated notable activity against liver & breast cancer.

   • According to LAHNGONG M (2025)

     Excerpt Conyza bonariensis (L.) Cronquist) is a medicinal plant with traditional use in Cameroonian folk medicine & other parts of Africa for the management of ailments, including malaria. Additionally, cytotoxicity was assessed on the MDA-MB-231 breast cancer cell line, while acute & sub-chronic toxicity were evaluated using albino mice.

   • According to Akhtar MF (2021)

     Excerpt To evaluate the anti-diabetic potential of aqueous methanolic extract of Conyza bonariensis amongst the Wistar rats. The plant extract revamped the pancreatic islets of Langerhans & abridged alloxan-induced degenerative changes in the liver.

3. 3

   Fungal infection: Candida albicans, C. parapsilosis, Malassezia furfur, M. globosa, M. sympodialis, Microsporum canis, Trichophyton rubrum, T. mentagrophytes

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mussin je (2017)

     Excerpt parapsilosis), 17 dermatophytes (6 Trichophyton rubrum, 6 Trichophyton mentagrophytes, 5 Microsporum canis) & 6 Staphylococcus aureus. Conclusions: Results allow to conclude that the CB tincture displays antibacterial activity against Staphylococcus aureus & antifungal activity against the main fungi causing superficial infections, such as dermatophytes, Candida & Malassezia.

   • According to GIRMA Y (2021)

     Excerpt Antimicrobial activity of the extracts was evaluated against pathogenic fungi causing superficial infection (Candida albicans, Malassezia globosa, & Malassezia furfur). In this study, crude extracts from leaves of Conyza bonariensis were prepared using methanol, ethyl acetate, hexane, & chloroform.

   • According to ARAUJO L (2013)

     Excerpt Additionally, the essential oil presented a significant bactericidal effect against Bacillus cereus, while a moderate activity was observed against Staphylococcus epidermidis & Candida albicans. The essential oil from aerial parts of Conyza bonariensis (L) Cronquist collected in Mérida was obtained by hydrodistillation & analysed by GC/MS.

   • According to MPENDA FN (2024)

     Excerpt Methods: Initial experimental activities involved preparation of crude extracts & EO, which were then, tested for antimicrobial activity against selected test organisms (Staphylococcus aureus (ATCC29213), Bacillus subtilis (ATCC6051), Escherichia coli (ATCC8736), Salmonella typhi (ATCC6539), & Candida albicans (DSM1665)) by using the disc diffusion method. albicans, where the MIC was 50 mg/mL > MIC > 25 mg/mL.

   • According to NSINDAGI SP (2023)

     Excerpt Then crude extracts were tested against selected microorganisms: Two Gram-positive bacteria, Staphylococcus aureus & Bacillus subtilis; Two Gram-negative bacteria, Escherichia coli & Salmonella typhi, & a yeast Candida albicans.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.