Cucumis sativus (Konkonb) : medicinal properties in alcoholic extraction

Cucumis sativus (Konkonb, Cucumber, Concombre) — family Cucurbitacées.

Scientific synonyms : Cucumis erinaceus-hort., Cucumis grassulariformis-hort..

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 14 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 37 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Muruganantham N (2016)

     Excerpt The compound isolated from ethyl acetate fraction of Cucumis sativus flowers was tested for its anti-cancer activity against liver cancer HePG2 cell line by MTT assay. This Present study explains a very superior anticancer action against liver cancer.

   • According to Heidari H (2012)

     Excerpt Conclusions: Our results showed that aqueous extract of C sativus acts as a hepatoprotective & antioxidant agent against CHP-induced hepatotoxicity suggesting that antioxidants & radical scavenging components of C sativus fruit extract can easily cross the cell membrane & cope with the intracellular ROS formation. Heidari H et al, Hepatoprotective activity of Cucumis sativus against cumene hydroperoxide induced-oxidative stress.

   • According to Muruganantham N (2016)

     Excerpt Fresh flowers of Cucumis sativus were extracted & evaluated for antioxidant activities by 2,2-Diphenyl 1-picryl hydrazyl solution (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sul- phenic acid (ABTS) assay & anti-inflammatory activities by human blood cell (HRBC) membrane stabilization method & Inhibition of albumin denaturation method. The results obtained showed that the compound isolated from ethyl acetate fractions of C sativus flowers can be considered as good sources of antioxidants, anti-inflammatory & can be incorporated into the drug formulations.

   • According to Mallik J (2012)

     Excerpt The present study was aimed to investigate phytochemical screening & to evaluate reducing power, cytotoxicity & antifungal activities of the ethanol extracts of peels of Cucumis sativus Linn (Cucurbitaceae). The qualitative phytochemical tests showed the presence of alkaloids, glycosides, saponins, flavonoids, steroids & tannins in the ethanol extract of C sativus while gums and reducing sugar were absent in the ethanol extract 3.

2. 2

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kathyayini T (2009)

     Excerpt The oral administration of 200 & 400 mg/kg body weight of ethanol extracts of powder fruit of C sativus exhibited significant antidiabetic effects in streptozotocin induced rats as compared to standard drug. In order to evaluate the antidiabetic activity of powder fruit of Cucumis sativus.

   • According to Heidari H (2012)

     Excerpt 7(5): S936-9, 2012.-Aims: The fruit of Cucumis sativus a plant that has long been used in oriental medicine for its anti-inflammatory, antidiabetic & abortifacient effects. Results: In the present study, the antioxidative potential of Cucumis sativus was evaluated in isolated rat hepatocytes and we tried to figure out whether Cucumis sativus could protect hepatocytes against cumene hydroperoxide (CHP) induced-cytotoxicity and ROS formation.

   • According to Saidu AN (2014)

     Excerpt Saidu AN et al, Phytochemical screening & hypoglycemic effect of methanolic fruit pulp extract of Cucumis sativus in alloxan induced diabetic rats.

   • According to Qamar M (2021)

     Excerpt It is known to anticipate antioxidant, anti-inflammatory, anticancer, anti-diabetic, anti-bacterial, antifungal, activities, & radioprotective activities. cumini have been used to cure renal issues, indigestion, diabetes, dysentery, & employed in folk medicine to treat inflammations.

3. 3

   Bacterial infection: Bacillus cereus, Bacillus subtilis, Streptococcus faecalis, three Gram-negative bacteria, namely Pseudomonas aeruginosa, Klebsiella aerogenes and Proteus vulgaris

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Gopalakrishna BS (2014)

     Excerpt Ethanolic extract of the fruits of Cucumis sativus had a minimum inhibitory concentration (MIC) of 200 µg/ml against three-gram positive bacteria, viz., Bacillus Cereus, Bacillus subtilis, Streptococcus faecalis, three-gram negative bacteria, viz., Pseudomonas aeruginosa, Klebsiella aerogenes, Proteus vulgaris & the two fungi, Candida albicans, Aspergillus flavens. Materials & methods: Antimicrobial activities of petroleum ether (40-60ºC), benzene, chloroform, ethanol & water extracts of the fruits of C sativus have been investigated against both bacteria & fungi using the disc diffusion method.

   • According to Mallik J (2012)

     Excerpt The present study was aimed to investigate phytochemical screening & to evaluate reducing power, cytotoxicity & antifungal activities of the ethanol extracts of peels of Cucumis sativus Linn (Cucurbitaceae). The qualitative phytochemical tests showed the presence of alkaloids, glycosides, saponins, flavonoids, steroids & tannins in the ethanol extract of C sativus while gums and reducing sugar were absent in the ethanol extract 3.

   • According to Qamar M (2021)

     Excerpt It is known to anticipate antioxidant, anti-inflammatory, anticancer, anti-diabetic, anti-bacterial, antifungal, activities, & radioprotective activities.

   • According to Janatunaim RZ (2014)

     Excerpt sativus fruit contain of glycosides, steroids, flavonoids, carbohydrates, terpenoids & tannins. Controls used in this research is a mixture of water with DMSO as much as three replicates.

   • According to Muruganantham N (2016)

     Excerpt Fresh flowers of Cucumis sativus were extracted & evaluated for antioxidant activities by 2,2-Diphenyl 1-picryl hydrazyl solution (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sul- phenic acid (ABTS) assay & anti-inflammatory activities by human blood cell (HRBC) membrane stabilization method & Inhibition of albumin denaturation method. The results obtained showed that the compound isolated from ethyl acetate fractions of C sativus flowers can be considered as good sources of antioxidants, anti-inflammatory & can be incorporated into the drug formulations.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.