Euphorbia neriifolia (Elaikalli) : medicinal properties in alcoholic extraction

Euphorbia neriifolia (Elaikalli) — family Euphorbiacées.

Scientific synonyms : Elaophorbia neriifolia-(L)-A.Chev, Euphorbia edulis-L, E. ligularis-Roxb., Tithymalus edulis-(L)-HK.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 20 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 50 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of liver and kidney cancer; chemoprevention of liver and kidney cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pracheta (n.d.)

     Excerpt This idea has prompted to evaluate the hepatoprotective properties of hydroethanolic extract of Euphorbia neriifolia (EN) Linn against N-Nitrosodiethylamine (DENA) induced liver cancer in mice. This study rationalized the ethnomedicinal use of the EN for curing liver cancer.

   • According to SHARMA V (2014)

     Excerpt The aim of this study was to examine the impacts of N-Nitrosodiethylamine (DENA), a potent environment carcinogen on liver tissue of mice which was attenuated by isolated flavonoid & hydro-ethanolic extract of E neriifolia (HEEN) leaves. neriifolia lower (ENL) & higher (ENH) dose & ENF before intoxicated with DENA showed that the liver cells were normal, with very little necrosis (Day 31).

   • According to SHARMA V (2012)

     Excerpt To scrutinize the protective role of hydroethanolic extract of E neriifolia leaves (HEEN) against N-Nitrosodiethylamine (DENA)-induced hepatocarcinogenesis in male Swiss albino mice .METHODS: Experimental mice were pretreated with 150 & 400 mg/kg of HEEN, or 0.5% & 1% of butylated hydroxyanisole (BHA) as a standard for 14 d prior to the administration of a single dose of 50 mg/kg of DENA. Levels of xenobiotic metabolizing enzymes such as cytochrome (Cyt) P450 & Cyt b5, activities of reduced glutathione (GSH), glutathione-S-transferase (GST), aspartate amino transaminase (AST), alanine amino transaminase (ALT) & alkaline phosphatase (ALP), & total protein and cholesterol content in the liver tissues were measured to determine the hepatotoxicity caused by DENA.

   • According to Pracheta (2011)

     Excerpt The present study was conducted to investigate the chemopreventive effects of hydroethanolic extract of Euphorbia neriifolia (EN) on N-Nitrosodiethylamine (DENA) induced renal cancer in male Swiss albino mice. This study rationalized the ethnomedicinal use of EN for protection against renal cancer.

   • According to SHARMA V (2013)

     Excerpt This study is an attempt to evaluate the tissue protective efficacy of isolated flavonoid & hydroethanolic extract of Euphorbia neriifolia (HEEN) leaves against N-Nitrosodiethylamine (DENA) induced renal carcinoma. On the other hand, the mice treated with E neriifolia lower (ENL) & higher (ENH) dose & ENF before intoxicated with DENA showed that the renal cells were normal (Day 31).

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to MANSURI MI (2013)

     Excerpt MANSURI MI et al, Evaluation of Antidiabetic and Antihyperlipidemic Activity of Euphorbia Neriifolia L in High Fat Diet- Streptozotocin Induced Type-2 Diabetic Model, Int Jl for Pharmaceut Res Scholars, 2(1-1) :83-9, 2013-Abstract Euphorbia neriifolia is traditionally used to treat diabetes mellitus. The purpose of this study was to examine the effect of repeated oral administration of the ethanolic extract of E neriifolia Linn at a dose of (200 and 400 mg/kg) on fasting blood glucose levels and lipid metabolism in streptozotocin induced type-2 diabetic rats.

   • According to Mansuri MI (2012)

     Excerpt Purpose of the study was to evaluate the antidiabetic activity of ethanolic extracts of leaves of E neriifolia in alloxan induced diabetic rats. The extract of Euphorbia neriifolia Linn are having potential in the development of drug for diabetes due to their antidiabetic activity.

   • According to Devi S (2023)

     Excerpt The scavenging activity of 2,2-diphenyl-2-picrylhydrazyl & hydrogen peroxide was used to study the antioxidant activity of hydroalcoholic extract of HAE) Plasma glucose content, lipid profiles, insulin levels, GLUT-4 protein content in muscle homogenates, inhibition of amylase & pancreatic glucosidase, & pancreatic histology were measured in control & diabetic rats. In the present study, the extract from the stem of Euphorbia neriifolia was used to investigate its antioxidant & antidiabetic activity.

   • According to Bigoniya P (2006)

     Excerpt neriifolia saponin fraction can be usefulness in the treatment of disorders that involve oxidative stress like cancer, cardiovascular diseases, diabetes & inflammation. Crude saponin was separated from hydroalcoholic extract of Euphorbia neriifolia leaf which contains Euphol as a major sapogenin.

   • According to Bigoniya P (2009)

     Excerpt neriifolia extract treatment extreme significantly (p < 0.001) reduced serum lipid profile along with glucose establishing its catabolic property. neriifolia leaf extract on some haematological, biochemical, histological & antioxidant enzyme status of rat liver & kidney following 21- & 45-days treatment.

3. 3

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pracheta (n.d.)

     Excerpt This idea has prompted to evaluate the hepatoprotective properties of hydroethanolic extract of Euphorbia neriifolia (EN) Linn against N-Nitrosodiethylamine (DENA) induced liver cancer in mice. The EN extract significantly restored the antioxidant enzyme level in the liver and exhibited significant dose dependant protective effect against DENA induced liver toxicity, which can be mainly attributed to the antioxidant property of the extract.

   • According to SHARMA V (2014)

     Excerpt The aim of this study was to examine the impacts of N-Nitrosodiethylamine (DENA), a potent environment carcinogen on liver tissue of mice which was attenuated by isolated flavonoid & hydro-ethanolic extract of E neriifolia (HEEN) leaves. neriifolia lower (ENL) & higher (ENH) dose & ENF before intoxicated with DENA showed that the liver cells were normal, with very little necrosis (Day 31).

   • According to SHARMA V (2012)

     Excerpt To scrutinize the protective role of hydroethanolic extract of E neriifolia leaves (HEEN) against N-Nitrosodiethylamine (DENA)-induced hepatocarcinogenesis in male Swiss albino mice .METHODS: Experimental mice were pretreated with 150 & 400 mg/kg of HEEN, or 0.5% & 1% of butylated hydroxyanisole (BHA) as a standard for 14 d prior to the administration of a single dose of 50 mg/kg of DENA. Levels of xenobiotic metabolizing enzymes such as cytochrome (Cyt) P450 & Cyt b5, activities of reduced glutathione (GSH), glutathione-S-transferase (GST), aspartate amino transaminase (AST), alanine amino transaminase (ALT) & alkaline phosphatase (ALP), & total protein and cholesterol content in the liver tissues were measured to determine the hepatotoxicity caused by DENA.

   • According to Bigoniya P (2009)

     Excerpt neriifolia leaf extract on some haematological, biochemical, histological & antioxidant enzyme status of rat liver & kidney following 21- & 45-days treatment. neriifolia showed an extremely significant (p < 0.001) rise in liver & kidney SOD along with liver catalase and decrease in liver lipid peroxidation.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.