Glycirrhiza glabra (Régis) : medicinal properties in alcoholic extraction

Glycirrhiza glabra (Régis, liquorice, réglisse) — family Fabacées.

Scientific synonyms : Glycyrrhiza brachycarpa Boiss., G glabra subsp. glandulifera (Waldst. & Kit.) Ponert, Glycyrrhiza glandulifera Waldst. & Kit., G hirsuta L., G officinalis Lepech., G pallida Boiss. & Noë, violacea Boiss. & Noë, Liquiritia officinalis Moench, Liquiritia officinarum Medi.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 289 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of breast, oral and liver cancer,

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Morsi MKS (2008)

     Excerpt Also the efficiency of licorice ethanolic extract as anticancer agent for breast, colon & liver was evaluated. Study revealed that ethanolic extract has strong antihepatic cancer activity at 16.1 µg/ml & anti breast cancer activity at 100 µg/ml, while it has no effect in colon cancer at 100 µg.

   • According to Rezaiyan Gharagozlu N (2018)

     Excerpt BAX and BCL2 gene expression levels in HepG2 cells treated by ethanol extract of GG were 1.90 ± 0.01 (P<0.05), & 0.64 ± 0.15, respectively (P<0.05); in HepG2 cells treated with aqueous extract of Glycyrrhiza glabra, the BAX & BCL2 gene expression levels were 1.4 ± 0.4 (P<0.05), and 0.70 ± 0.5 (P<0.05), respectively.Conclusion: GG extract (especially ethanoic extract) has potential uses for treatment of liver cancer. Glycyrrhiza glabra plants are known to have anti- cancer effects in traditional medicine with high antioxidant properties and few side effects.

   • According to Stecanella LA (2021)

     Excerpt Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid, obtained from the plant Glycyrrhiza glabra, have numerous pharmacological activities, such as anti-inflammatory, anti-ulcerative, antiallergic, immunomodulatory, antiviral, antitumor, hepatoprotective, & antioxidant effects, & others. This review describes experimental evidence of vectorization by conjugating glycyrrhizic acid or glycyrrhetinic acid to nanosystems & delivery of antitumor drugs for the treatment of liver cancer & also describes the techniques used to perform this conjugation.

   • According to Hasan K (2023)

     Excerpt Several compounds such as glycyrrhizin, glycyrrhizinic acid, isoliquiritin, & glycyrrhizic acid have been found in this plant, which can provide pharmacological benefit to us with its anti-cancer, anti-atherogenic, anti-diabetic, anti-asthmatic, anti-inflammatory, anti-microbial, & antispasmodic activity. Alongside, these products have a different role in hepatoprotective, immunologic, memory-enhancing activity.

   • According to Nassiri Asl (2008)

     Excerpt GG root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, & pulmonary and skin diseases, although clinical & experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective & cardioprotective effects.

2. 2

   Liver disorders: hepatitis, cirrhosis, fatty liver, diclofenac-induced hepatotoxicity

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nassiri Asl (2008)

     Excerpt GG root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, & pulmonary and skin diseases, although clinical & experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective & cardioprotective effects.

   • According to Al-Razzuqi R (2012)

     Excerpt The present study was done to evaluate the hepatoprotective effect of aqueous extract of Glycyrrhiza glabra roots in rabbit models with acute liver injury induced by Carbon tetrachloride at a dose of 1.25 ml/kg as a mixture with olive oil. glabra had a significant effect in amiolerating liver functions as well as restoring hepatic tissue in acute liver diseases when it was given in a single dose per day of 2gm/kg body weight.

   • According to Morsi MKS (2008)

     Excerpt Also the efficiency of licorice ethanolic extract as anticancer agent for breast, colon & liver was evaluated. Glycyrrhizia glabra roots was analyzed for its major constant.

   • According to Hamza AA (2007)

     Excerpt They all showed a novel hepatoprotective effects against DIC-induced hepatotoxicity in rats. Diclofenac (DIC) is a widely used anti-inflammatory drug that causes liver toxicity.

   • According to Abd-Al-Sattar S.L (2016)

     Excerpt Thus, we can conclude that the QGC & EGG (250 mg/kg & 500 mg/kg) possesses dose-dependent, significant protective activity against acute liver injury induced by CCL4 & this activity can be attributed to the antioxidant property of GG. Hepatoprotective potential of aqueous extract of Glycyrrhiza glabra (QGG) & ethanol extract of G.

3. 3

   Fungal infection: Aspergillus flavus, Aspergillus niger, Candida albicans, Candida glabrata, Candida parapsilosis and Candida tropicalis

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Martins N (2014)

     Excerpt glabra hydroalcoholic extract probably exerts mainly fungicidal & not so much fungistatic effects, & it could find applications in antifungal therapy. is commonly used in folk medicine due to its antimicrobial a&antiviral activities, as well as for a wide variety of dermal affections [2].

   • According to Sharma H (2016)

     Excerpt Sharma H et al, Antifungal efficacy of three medicinal plants Glycyrrhiza glabra, Ficus religiosa, & Plantago major against oral Candida albicans: A comparative analysis.

   • According to Chopra P.K.P (2013)

     Excerpt Chopra P.K.P et al, Antimicrobial & antioxidant activities of methanol extract roots of Glycyrrhiza glabra & HPLC analysis.

   • According to El-Saber Batiha G. (2020)

     Excerpt Additionally, it shows antioxidant, antifungal, anticarcinogenic, anti-inflammatory, & cytotoxic activities.

   • According to Al-Snafi A.E (2018)

     Excerpt The phytochemical screening of the Glycyrrhiza glabra root revealed the presence of alkaloids, glycosides, carbohydrates, starches, phenolic compounds, flavonoids, proteins, pectin, mucilage, saponins, lipids, tannins, sterols & steroids. It showed memory enhancement, antidepressant, antimicrobial, anticancer, antioxidant, protective, antiinflammatory, antiulcer, antidiabetic, hypolipidemic & many other pharmacological effects.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.