Glycirrhiza glabra (Régis) : propiedades medicinales en extracción alcohólica

Glycirrhiza glabra (Régis, regaliz, réglisse, liquorice) — familia Fabacées.

Sinónimos científicos : Glycyrrhiza brachycarpa Boiss., G glabra subsp. glandulifera (Waldst. & Kit.) Ponert, Glycyrrhiza glandulifera Waldst. & Kit., G hirsuta L., G officinalis Lepech., G pallida Boiss. & Noë, violacea Boiss. & Noë, Liquiritia officinalis Moench, Liquiritia officinarum Medi.

Fuentes externas reconocidas asociadas a esta monografía: Farmacopea francesa.

Esta base documenta las extracciones alcohólicas (etanol) de las sustancias activas. Nuestra monografía recoge actualmente 17 indicaciones en extracción alcohólica para esta especie. El catálogo Lapo v2 registra 289 referencias científicas para esta especie (detalle completo en la aplicación).

Indicaciones terapéuticas en extracción alcohólica:

Importante — referencias científicas en esta página pública: solo se muestra un breve extracto de cada fuente citada (frases de resumen seleccionadas), conservado en el idioma original de la publicación (casi siempre el inglés), sin traducir. Estos extractos no constituyen el texto íntegro del artículo ni una bibliografía completa. Las fichas de referencia completas y el detalle monográfico están disponibles en la aplicación Lapo v2 (prueba gratuita de 30 días).

1. 1

   Cáncer: tratamiento adyuvante del carcinoma de mama, oral y hepático,

   Parte usada: raíz.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Morsi MKS (2008)

     Extrait Also the efficiency of licorice ethanolic extract as anticancer agent for breast, colon & liver was evaluated. Study revealed that ethanolic extract has strong antihepatic cancer activity at 16.1 µg/ml & anti breast cancer activity at 100 µg/ml, while it has no effect in colon cancer at 100 µg.

   • Selon Rezaiyan Gharagozlu N (2018)

     Extrait BAX and BCL2 gene expression levels in HepG2 cells treated by ethanol extract of GG were 1.90 ± 0.01 (P<0.05), & 0.64 ± 0.15, respectively (P<0.05); in HepG2 cells treated with aqueous extract of Glycyrrhiza glabra, the BAX & BCL2 gene expression levels were 1.4 ± 0.4 (P<0.05), and 0.70 ± 0.5 (P<0.05), respectively.Conclusion: GG extract (especially ethanoic extract) has potential uses for treatment of liver cancer. Glycyrrhiza glabra plants are known to have anti- cancer effects in traditional medicine with high antioxidant properties and few side effects.

   • Selon Stecanella LA (2021)

     Extrait Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid, obtained from the plant Glycyrrhiza glabra, have numerous pharmacological activities, such as anti-inflammatory, anti-ulcerative, antiallergic, immunomodulatory, antiviral, antitumor, hepatoprotective, & antioxidant effects, & others. This review describes experimental evidence of vectorization by conjugating glycyrrhizic acid or glycyrrhetinic acid to nanosystems & delivery of antitumor drugs for the treatment of liver cancer & also describes the techniques used to perform this conjugation.

   • Selon Hasan K (2023)

     Extrait Several compounds such as glycyrrhizin, glycyrrhizinic acid, isoliquiritin, & glycyrrhizic acid have been found in this plant, which can provide pharmacological benefit to us with its anti-cancer, anti-atherogenic, anti-diabetic, anti-asthmatic, anti-inflammatory, anti-microbial, & antispasmodic activity. Alongside, these products have a different role in hepatoprotective, immunologic, memory-enhancing activity.

   • Selon Nassiri Asl (2008)

     Extrait GG root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, & pulmonary and skin diseases, although clinical & experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective & cardioprotective effects.

2. 2

   Trastornos hepáticos: hepatitis, cirrosis, esteatosis hepática, hepatotoxicidad inducida por el diclofenaco

   Parte usada: raíz.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Nassiri Asl (2008)

     Extrait GG root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, & pulmonary and skin diseases, although clinical & experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective & cardioprotective effects.

   • Selon Al-Razzuqi R (2012)

     Extrait The present study was done to evaluate the hepatoprotective effect of aqueous extract of Glycyrrhiza glabra roots in rabbit models with acute liver injury induced by Carbon tetrachloride at a dose of 1.25 ml/kg as a mixture with olive oil. glabra had a significant effect in amiolerating liver functions as well as restoring hepatic tissue in acute liver diseases when it was given in a single dose per day of 2gm/kg body weight.

   • Selon Morsi MKS (2008)

     Extrait Also the efficiency of licorice ethanolic extract as anticancer agent for breast, colon & liver was evaluated. Glycyrrhizia glabra roots was analyzed for its major constant.

   • Selon Hamza AA (2007)

     Extrait They all showed a novel hepatoprotective effects against DIC-induced hepatotoxicity in rats. Diclofenac (DIC) is a widely used anti-inflammatory drug that causes liver toxicity.

   • Selon Abd-Al-Sattar S.L (2016)

     Extrait Thus, we can conclude that the QGC & EGG (250 mg/kg & 500 mg/kg) possesses dose-dependent, significant protective activity against acute liver injury induced by CCL4 & this activity can be attributed to the antioxidant property of GG. Hepatoprotective potential of aqueous extract of Glycyrrhiza glabra (QGG) & ethanol extract of G.

3. 3

   Infección fúngica: Aspergillus flavus, Aspergillus niger, Candida albicans, C. glabrata, C. parapsilosis y C. tropicalis

   Parte usada: raíz.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Martins N (2014)

     Extrait glabra hydroalcoholic extract probably exerts mainly fungicidal & not so much fungistatic effects, & it could find applications in antifungal therapy. is commonly used in folk medicine due to its antimicrobial a&antiviral activities, as well as for a wide variety of dermal affections [2].

   • Selon Sharma H (2016)

     Extrait Sharma H et al, Antifungal efficacy of three medicinal plants Glycyrrhiza glabra, Ficus religiosa, & Plantago major against oral Candida albicans: A comparative analysis.

   • Selon Chopra P.K.P (2013)

     Extrait Chopra P.K.P et al, Antimicrobial & antioxidant activities of methanol extract roots of Glycyrrhiza glabra & HPLC analysis.

   • Selon El-Saber Batiha G. (2020)

     Extrait Additionally, it shows antioxidant, antifungal, anticarcinogenic, anti-inflammatory, & cytotoxic activities.

   • Selon Al-Snafi A.E (2018)

     Extrait The phytochemical screening of the Glycyrrhiza glabra root revealed the presence of alkaloids, glycosides, carbohydrates, starches, phenolic compounds, flavonoids, proteins, pectin, mucilage, saponins, lipids, tannins, sterols & steroids. It showed memory enhancement, antidepressant, antimicrobial, anticancer, antioxidant, protective, antiinflammatory, antiulcer, antidiabetic, hypolipidemic & many other pharmacological effects.

Otras indicaciones (incluidos otros modos de extracción si procede), posologías, precauciones de uso y las <strong>referencias científicas completas</strong> (fichas íntegras, no solo los extractos cortos anteriores) están disponibles en la ficha monográfica de la aplicación Lapo v2.