Gmelina arborea (Kolkata) : medicinal properties in alcoholic extraction

Gmelina arborea (Kolkata, White teak, Tèk blan, Teck blanc) — family Verbénacées.

Scientific synonyms : Gmelina arborea var. glaucescens. Clarke, Premna arborea-Farw.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 52 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nayak BS (2015)

     Excerpt The plant Gmelina arborea has been traditionally used in India for several medicinal purposes like anthelmintic, diuretic, anti-inflammatory, antibacterial & antidiabetic. The antidiabetic activity of above extracts was evaluated in alloxan induced diabetic model of Wistar rats.

   • According to Pattanayak P (2011)

     Excerpt In the present investigation we have screened the Benzene, chloroform ethanolic, & aqueous extracts of the heart wood bark of the plant Gmelina arborea (family Verbenaceae) for antidiabetic activity in Streptozotocin (STZ) induced Diabetic rats and emphasized the mechanism of its antidiabetic property. The observed significant antidiabetic activity of the ethanolic extract could be attributed to the increased blood GSH levels reinforcing the role of GSH as free radical scavenger & in the repair of free radical caused biological damage.

   • According to Kulkarni YA (2013)

     Excerpt To study the effects of aqueous extract of Gmelina arborea bark on normoglycemic levels & streptozotocin (STZ) induced diabetes in rats. The diabetic animals were divided into four groups containing six in each: Group I diabetic control, Group II & III treated with the aqueous extract respectively at a dose of 250 & 500 mg/kg body weight once daily & Group IV treated with Glibenclamide at a dose of 0.6 mg/kg body weight once daily.

   • According to Opara MN (n.d.)

     Excerpt This study reveals the anti-diabetic properties of aqueous extracts & its ability to enhance renal function.

   • According to Kayode O (2017)

     Excerpt The animals were randomly grouped into four & assigned to four treatments of 0 (T1), 150 (T2), 300 (T3), & 450 mL/L (T4) of aqueous extracts of Gmelina arborea, prepared from freshly harvested GA leaves & administered through drinking water. This study reveals the anti-diabetic properties of aqueous extracts of GA leaves & its ability to enhance renal function.

2. 2

   Cancer: adjuvant treatment of oesophageal, colorectal and gastric carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2012)

     Excerpt In the present study, the cytotoxicity of ethanolic leaf extracts of Gmelina arborea was tested against Colon cancer (COLO 201), Gastric cancer (HT- 29) & Human esophageal cancer (TE-2) cell lines using the thiazolyl blue test (MTT) assay. Cancer is one of the most common devastating disease affecting millions of people per Year.

   • According to LUKMAN M (2014)

     Excerpt Gmelina arborea Roxb, Guazuma ulmifolia Lamk & Curculigo orchioides Gaerth, the three plants frequently used in South Sulawesi for the treatment of cancerous diseases, have been selected to examine their action in cervical epithelial carcinoma. Dose-dependent studies revealed IC50 of 113.61±0.12 µg/mL, 174.90±1.22 µg/mL & 126.05±2.43 µg/mL for e-GA, e-GU & e-CO on HeLa cell cancer, respectively & correlated with treatment of cancer.

   • According to Rohit S (n.d.)

     Excerpt Aqueous Extract of Gmelina arborea Roxb (AEGA) was tested at the various concentrations 5, 10, 15 & 20 mg in MTT assay, Cell Viability assays & clonogenic assay. We tested the cytotoxic potential of Gmelina arborea Roxb in HL-60 cells.

   • According to Author (2017)

     Excerpt Gmelina arborea Roxb commonly known as ‘Gambhari’ tree, the various parts of the plants are widely used in diarrhoea, anti-pyretic, thirst, anemia, leprosy, ulcers, consumption, strangury & vaginal discharges. Overall, AEGA has shown a substantial & significant anti-cancer activity in all the models.

3. 3

   Inflammatory conditions: osteoarthritis, arthritis, rheumatism

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nayak BS (2017)

     Excerpt The anti-inflammatory activity of phytoconstituent was evaluated by Carrageenan-induced rat paw edema test method using Wistar rats as animal model. arborea & to explore the anti-inflammatory activity of isolated compound.

   • According to Nayak BS (2015)

     Excerpt The plant Gmelina arborea has been traditionally used in India for several medicinal purposes like anthelmintic, diuretic, anti-inflammatory, antibacterial & antidiabetic. arborea possess anthelmintic & antidiabetic activities,.

   • According to Opara MN (n.d.)

     Excerpt This study reveals the anti-diabetic properties of aqueous extracts & its ability to enhance renal function.

   • According to Kayode O (2017)

     Excerpt The animals were randomly grouped into four & assigned to four treatments of 0 (T1), 150 (T2), 300 (T3), & 450 mL/L (T4) of aqueous extracts of Gmelina arborea, prepared from freshly harvested GA leaves & administered through drinking water. This study reveals the anti-diabetic properties of aqueous extracts of GA leaves & its ability to enhance renal function.

   • According to Rohit S (n.d.)

     Excerpt Aqueous Extract of Gmelina arborea Roxb (AEGA) was tested at the various concentrations 5, 10, 15 & 20 mg in MTT assay, Cell Viability assays & clonogenic assay. We tested the cytotoxic potential of Gmelina arborea Roxb in HL-60 cells.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.