Khaya senegalensis (Senegalese mahogany) : medicinal properties in alcoholic extraction

Khaya senegalensis (Senegalese mahogany, Royal Caïlcedrat, Acajou du Sénégal, Mahogani du Sénégal, Caïlcedrat royal) — family Méliacées.

Scientific synonyms : Swietenia senegalensis-Desv.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 25 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Widdat Allah MO (2019)

     Excerpt Khaya senegalensis has traditionally used in the management of diabetes. The leaves & bark of the plant were extracted with ethanol 96%, & then tested for anti-diabetic activity in a series of in vitro models & a type 2 diabetes model of rats.

2. 2

   Cancer: chemoprevention of colorectal carcinoma

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Andreoulakis XM (2006)

     Excerpt Khaya senegalensis bark extract (KSBE) was hypothesized to contain inhibitors of the cyclooxygenase-2 (COX-2) gene & to be useful in the prevention and treatment of colorectal cancer. An extract of the bark of Khaya senegalensis is commonly used in African traditional medicine for pain & inflammation.

   • According to Zhang H (2007)

     Excerpt Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), & their structures were identified as 3alpha,7alpha-dideacetylkhivorin (1) & 1-O-acetylkhayanolide B (2) on the basis of MS & NMR spectral data.

   • According to Rabadeux C (2017)

     Excerpt Khaya senegalensis (Desr.) A. This study was undertaken to test KS bark extracts for the ability to inhibit microbial & cancer cell growth, & thus to validate traditional African medicinal usage of this plant in treating a variety of diseases.

   • According to Olugbami OJ (2017)

     Excerpt In this study, therefore, we evaluated the antimetastatic potentials of an extract of Khaya senegalensis & curcumin on the metastatic liver cell line HepG2, & also assessed the anticancer property of the extract. Treated cells were assessed as follows: nanotechnologically—atomic force microscopy (AFM) was used to determine cell stiffness; biochemically—cell cytotoxicity, glutathione level & adenosine triphosphate status, caspase activation & mitochondrial toxicity were considered; & microbiologically—a carrot disk assay was used to assess the anticancer property of the extract of KS.

3. 3

   Bacterial infection: Escherichia coli, Salmonella typhii, Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus faecalis, Shigella sp

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Wakirwa JH (2010)

     Excerpt Khaya senegalensis ethanol leaf extract was examined for antimicrobial potential against some selected clinical isolates (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae & Candida albicans). Khaya senegalensis is an important multipurpose tree in its natural range in sub-Saharan Africa.

   • According to Jiang YH (2022)

     Excerpt Three new mexicanolide limonoids were obtained from the 90% ethanol extract of the seeds of Khaya senegalensis. Consequently, compounds 1–3 exhibited antimicrobial activity against the tested Gram negative bacteria at the minimum inhibitory concentration values less than 40 μg/ml.

   • According to Makut DM (2008)

     Excerpt The test organisms were Staphylococcus aureus, Steptococcus faecalis, Escherichia coli & Candida albicans. Khaya senegalensis , a member of the family Meliaceae, is a plant commonly used by the local people of Nasarawa State of Nigeria for the treatment of dysentery, mucous diarrhoea & wound infections.

   • According to Abdallah (2016)

     Excerpt Khaya senegalensis leaf extracts contain some bioactive ingredients which include; saponins, alkaloids, tannins & flavonoids.

   • According to Yuan CM (2013)

     Excerpt Eight new limonoids, khayseneganins A–H (1–8), & 31 known limonoids were isolated from the leaves & twigs of Khaya senegalensis. Compounds 9, 10, 12, & 15 showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92#, & MRSA 98#, all with a MIC value of 12.5 μg/mL.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.