Morinda cirifolia (Monkey apple) : medicinal properties in alcoholic extraction

Morinda cirifolia (Monkey apple, Cat vomit, Ponm makak, Vonmi-chat, pomme -à-macaque, Vomissure de chat) — family Rubiacées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 32 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 184 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Diabetic foot

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jadhav ND (2017)

     Excerpt Jadhav ND et al, Studies of Anti-Diabetic Effect of Morinda citrifolia Fruit Juice on Alloxan Induced Diabetic Rat Int.

   • According to Nayak BS (2007)

     Excerpt This study aimed to evaluate the wound-healing activity of Morinda citrifolia fruit juice in streptozotocin-induced diabetic rats. Histological studies showed that collagen was laid down faster in the experimental diabetic animals than in the normal control & diabetic control groups.

   • According to OWEN PL (2008)

     Excerpt Rapid increase in the incidence of type 2 diabetes (DM2) in Papua New Guinea, coupled with compelling epidemiological evidence supporting a diabetogenic association with betel quid (BQ) chewing has led us to investigate dietary strategies that might offer protection from developing DM2. These plants, along with BQ & its component ingredients areca nut (Areca catechu L) & Piper betle L inflorescence, were assessed for their ability to mediate insulin-dependent & insulin-independent glucose transport in cultured 3T3-L1 adipocytes.

   • According to Rao USM (2009)

     Excerpt The hypoglycemic & antioxidative effects of Morinda citrifolia fruit extract were evaluated in streptozotocin (STZ)-induced diabetic rats. The ethanolic extract of MC fruit at a concentration of 300 mg/kg body weight/rat/day was orally administered to STZ-induced diabetic rats for a period of 30 days.

   • According to Author (2012)

     Excerpt Morinda citrifolia (Noni) fruits have been used traditionally to treat diabetes, high blood pressure, cancer, mechanical injury, & arthritis.

2. 2

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nayak BS (2007)

     Excerpt This study aimed to evaluate the wound-healing activity of Morinda citrifolia fruit juice in streptozotocin-induced diabetic rats. Histological studies showed that collagen was laid down faster in the experimental diabetic animals than in the normal control & diabetic control groups.

   • According to OWEN PL (2008)

     Excerpt Rapid increase in the incidence of type 2 diabetes (DM2) in Papua New Guinea, coupled with compelling epidemiological evidence supporting a diabetogenic association with betel quid (BQ) chewing has led us to investigate dietary strategies that might offer protection from developing DM2. These plants, along with BQ & its component ingredients areca nut (Areca catechu L) & Piper betle L inflorescence, were assessed for their ability to mediate insulin-dependent & insulin-independent glucose transport in cultured 3T3-L1 adipocytes.

   • According to Rao USM (2009)

     Excerpt The hypoglycemic & antioxidative effects of Morinda citrifolia fruit extract were evaluated in streptozotocin (STZ)-induced diabetic rats. The ethanolic extract of MC fruit at a concentration of 300 mg/kg body weight/rat/day was orally administered to STZ-induced diabetic rats for a period of 30 days.

   • According to Author (2012)

     Excerpt Morinda citrifolia (Noni) fruits have been used traditionally to treat diabetes, high blood pressure, cancer, mechanical injury, & arthritis.

   • According to Algenstaedt P (2018)

     Excerpt Methods: M citrifolia fruit juice (NFJ), 2 ml per kg bw per day, was consumed by twenty patients with DT2 after they underwent a standard treatment regimen including carbohydrate reduced diet and treatment with an antidiabetic drug and/or insulin. The effect of the daily consumption of Morinda citrifolia (Noni) fruit juice on the physiological status of patients with diabetes type 2 (DT2) was tested over a period of two months.

3. 3

   Cancer: chemoprevention and enhancement of anti-cancer radiotherapy

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2012)

     Excerpt A Medline search was conducted using the key search words 'Morinda citrifolia'& 'Morinda citrifolia & cancer' (1964 to October, 2011) along with cross-referencing. Among the in vitro studies, a 'concentrated component' in noni juice & not pure noni juice may (1) stimulate the immune system to 'possibly' assist the body fight the cancer, & (2) kill a small percentage (0-36%) of cancer cells depending on the type.

   • According to SATYAMOORTHY K, Bioassay based discovery of anticancer drugs from fruits of Noni, Morinda citrifolia L. WNRF Technical Bull 15, 2014-Abstract

     Excerpt Chemopreventive agents are non-Toxic & might exert their effects either by blocking or metabolizing carcinogens or by inhibiting tumor cell growth (Sarkar (2014) — excerpt: Growing evidence has shown that chemopreventive agents potentiate the efficacy of Chemotherapy & radiotherapy through the regulation of multiple signaling pathways, including Akt, NF-ºB, cMyc, cyclooxygenase-2, apoptosis & others suggesting a multitargeted nature of chemopreventive agents (Sarkar et al.

   • According to Beh HK (2012)

     Excerpt The methanol extracts of fruits & leaves of MC & the subsequent chloroform fraction of the fruit methanolic extract were found to have potential anti-angiogenic activity & were more potent compared to suramin. Scopoletin was identified as one of the chemical constituents that may be partly responsible for the anti-angiogenic activity of MC fruits.

   • According to Kitic D (1932)

     Excerpt Recently, there has been an increased focus on exploring Noni extracts & phytoconstituents, particularly for their effectiveness against cancers such as lung, esophageal, liver, & breast cancer, & their potential in cancer chemoprevention. This review focused on in vitro & in vivo studies, as well as clinical trials that explore the effects of MC fruit & its phytoconstituents-including anthraquinones, flavonoids, sugar derivatives, & neolignans-on cancer.

   • According to Blanco YC (2006)

     Excerpt If, in the future, the nutritional and medical values of the noni can be assessed, especially its anti-cancer activity, this fruit could play a noticeable economic role in producing countries,. However, both the fruit & damnacanthal, an anthraquinone compound extracted from noni roots, are currently being studied in the context of anti-cancer research.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.