Morinda cirifolia (Monkey apple) : medicinal properties in alcoholic extraction

Morinda cirifolia (Monkey apple, Cat vomit, Ponm makak, Vonmi-chat, pomme -à-macaque, Vomissure de chat, manzana de macaco, vómito de gato) — family Rubiacées.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 33 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 185 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Diabetic foot

   Plant part used: fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jadhav ND (2017)

     Excerpt Jadhav ND et al, Studies of Anti-Diabetic Effect of Morinda citrifolia Fruit Juice on Alloxan Induced Diabetic Rat Int.

   • According to Nayak BS (2007)

     Excerpt This study aimed to evaluate the wound-healing activity of Morinda citrifolia fruit juice in streptozotocin-induced diabetic rats. Histological studies showed that collagen was laid down faster in the experimental diabetic animals than in the normal control & diabetic control groups.

   • According to OWEN PL (2008)

     Excerpt Rapid increase in the incidence of type 2 diabetes (DM2) in Papua New Guinea, coupled with compelling epidemiological evidence supporting a diabetogenic association with betel quid (BQ) chewing has led us to investigate dietary strategies that might offer protection from developing DM2. These plants, along with BQ & its component ingredients areca nut (Areca catechu L) & Piper betle L inflorescence, were assessed for their ability to mediate insulin-dependent & insulin-independent glucose transport in cultured 3T3-L1 adipocytes.

   • According to Rao USM (2009)

     Excerpt The hypoglycemic & antioxidative effects of Morinda citrifolia fruit extract were evaluated in streptozotocin (STZ)-induced diabetic rats. The ethanolic extract of MC fruit at a concentration of 300 mg/kg body weight/rat/day was orally administered to STZ-induced diabetic rats for a period of 30 days.

   • According to Okamoto H (2012)

     Excerpt Morinda citrifolia (Noni) fruits have been used traditionally to treat diabetes, high blood pressure, cancer, mechanical injury, & arthritis.

2. 2

   Type II diabetes mellitus

   Plant part used: fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nayak BS (2007)

     Excerpt This study aimed to evaluate the wound-healing activity of Morinda citrifolia fruit juice in streptozotocin-induced diabetic rats. Histological studies showed that collagen was laid down faster in the experimental diabetic animals than in the normal control & diabetic control groups.

   • According to OWEN PL (2008)

     Excerpt Rapid increase in the incidence of type 2 diabetes (DM2) in Papua New Guinea, coupled with compelling epidemiological evidence supporting a diabetogenic association with betel quid (BQ) chewing has led us to investigate dietary strategies that might offer protection from developing DM2. These plants, along with BQ & its component ingredients areca nut (Areca catechu L) & Piper betle L inflorescence, were assessed for their ability to mediate insulin-dependent & insulin-independent glucose transport in cultured 3T3-L1 adipocytes.

   • According to Rao USM (2009)

     Excerpt The hypoglycemic & antioxidative effects of Morinda citrifolia fruit extract were evaluated in streptozotocin (STZ)-induced diabetic rats. The ethanolic extract of MC fruit at a concentration of 300 mg/kg body weight/rat/day was orally administered to STZ-induced diabetic rats for a period of 30 days.

   • According to Okamoto H (2012)

     Excerpt Morinda citrifolia (Noni) fruits have been used traditionally to treat diabetes, high blood pressure, cancer, mechanical injury, & arthritis.

   • According to Algenstaedt P (2018)

     Excerpt Methods: M citrifolia fruit juice (NFJ), 2 ml per kg bw per day, was consumed by twenty patients with DT2 after they underwent a standard treatment regimen including carbohydrate reduced diet and treatment with an antidiabetic drug and/or insulin. The effect of the daily consumption of Morinda citrifolia (Noni) fruit juice on the physiological status of patients with diabetes type 2 (DT2) was tested over a period of two months.

3. 3

   Cancer: enhancing the effectiveness of anti-tumour chemotherapy

   Plant part used: fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Santiago K (2010)

     Excerpt Santiago K et al, Evaluation of the Hepatic Metabolism & Antitumor Activity of Noni Juice (Morinda citrifolia L.) in Combination with Chemotherapy, J of the Society for Integr Oncol, 8, (3): 89, 2010,.

   • According to SATYAMOORTHY K, Bioassay based discovery of anticancer drugs from fruits of Noni, Morinda citrifolia L. WNRF Technical Bull 15, 2014-Abstract

     Excerpt Chemopreventive agents are non-Toxic & might exert their effects either by blocking or metabolizing carcinogens or by inhibiting tumor cell growth (Sarkar (2014) — excerpt: Growing evidence has shown that chemopreventive agents potentiate the efficacy of Chemotherapy & radiotherapy through the regulation of multiple signaling pathways, including Akt, NF-ºB, cMyc, cyclooxygenase-2, apoptosis & others suggesting a multitargeted nature of chemopreventive agents (Sarkar et al.

   • According to Beh HK (2012)

     Excerpt The methanol extracts of fruits & leaves of MC & the subsequent chloroform fraction of the fruit methanolic extract were found to have potential anti-angiogenic activity & were more potent compared to suramin. Scopoletin was identified as one of the chemical constituents that may be partly responsible for the anti-angiogenic activity of MC fruits.

   • According to Moongkarndi P (2004)

     Excerpt niruri] whole plant, Passiflora foetida aerial part, Ardisia elliptica fruit, Morinda citrifolia fruit, Aegle marmelos fruit, Heliotropium indicum whole plant, Stephania venosa [Stephania rotunda] bulb a& Thunbergia laurifolia leaf) were tested for antiproliferative activity against SKBR3 human breast adenocarcinoma cell line using MTT assay. However, all the plant extracts showed activity in potential range for further investigation on cancer cells, showed activity in potential range for further investigation on cancer cells.

   • According to Narayankar C (2021)

     Excerpt The results showed a significant anticancer & cytotoxic effect of M citrifolia against PC-3 human cancer cell lines, & thus supported the ethnomedical use of M citrifolia,. Morinda citrifolia fruit is well known traditional medicine that has both antioxidant & anticancer activity.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.