Morus alba (Mulberry tree) : medicinal properties in alcoholic extraction

Morus alba (Mulberry tree, The Three Wise Men, Murier, Les Trois rois mages, Morera, Los tres Reyes Magos) — family Moracées.

Scientific synonyms : Morus atropurpurea Roxb, M chinensis Lodd. E Loudon, M latifolia Poir, M multicaulis (Perr.) P, Morus tatarica L..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 31 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 176 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to HE X (2018)

     Excerpt MA fruits & leaves contain rich bioactive polysaccharides, which are shown to possess various promising bioactivities, mainly including antidiabetic, immunomodulation, anti-inflammation, antioxidation, anti-obesity, hepatoprotection & renoprotection.

   • According to Habeeb MN (2012)

     Excerpt The aim of the present study was to evaluate the hypoglycemic activity of Morus alba extract from different grades of alcohol and to know which grade is a potent inhibitor of - amylase & - glucosidase enzymes.

   • According to Fauzi A (2024)

     Excerpt Results: Morus alba leaf depicted total phenolic 10.93 mg gallic acid equivalents (GAE)/g dry weight (DW), flavonoid 256.67 mg quercetin equivalents (QE)/g DW, & antioxidant bioactivity content of 602.03 IC50 μg/mL & 13.21 mg Fe2+/g DW. Phytochemical compounds in the leaves demonstrated the ability to enhance insulin sensitivity & β-cell secretory function, suggesting their potential value in reducing blood glucose & treating diabetes.

   • According to Mohammadi J (2008)

     Excerpt The objective of the present investigation was to evaluate the therapeutic efficacy of Morus alba leaves in an animal model of diabetes. Results: Blood glucose level &other parameters (except HDL) were elevated in the diabetic group, but were brought to control group level in the diabetic group treated with 600 mg/kg body weight of MA leaf extract.

   • According to Singab AK (2005)

     Excerpt The hypoglycemic activity of the flavonoids rich fraction of 70% alcohol extract of the Egyptian Morus alba root bark (MRBF-3) was evaluated after its oral administration to streptozotocin-induced diabetic rats. The administration of MRBF-3 to streptozotocin (STZ)-diabetic rats for 10 days in a dose of 200 & 400 mg kg (-1) day (-1) was not significant.

2. 2

   Abnormal serum levels: SGOP, SGPT, alkaline phosphatase (SALP)

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Fathy SA (2013)

     Excerpt this study aimed to investigate the effect of aqueous & organic extracts of mulberry leaves (Morus Alba L.) on human hepatocellular carcinoma HepG2 cell line. leaves on HepG2 cell viability, nuclear factor kappa B (NF-κB) gene expression, alfa-fetoprotein (AFP), albumin (ALB), gamma-glutamyl transpeptidase (γ-GT) & alkaline phosphatase(ALP) were measured.

   • According to Fauzi A (2024)

     Excerpt On the other hand, administration of 500 & 1000 mg/kg MLE resulted in mild hepatocellular injury, as indicated by a significant (p < 0.05) increase in liver enzyme activities of alanine aminotransferase (ALT) & aspartate aminotransferase (AST). Results: Morus alba leaf depicted total phenolic 10.93 mg gallic acid equivalents (GAE)/g dry weight (DW), flavonoid 256.67 mg quercetin equivalents (QE)/g DW, & antioxidant bioactivity content of 602.03 IC50 μg/mL & 13.21 mg Fe2+/g DW.

   • According to Naowaratwattana W (2010)

     Excerpt The entire plant of Morus alba L. In this study, we investigated the effect of MA leaf extracts on the human hepatoma HepG2 cell line, which is related to hepatocellular carcinoma.

   • According to Zeni ALB (2010)

     Excerpt Therefore, the treatment not only decreased the plasma level of triglycerides but also affected a hepatic enzyme tested supporting the fact that the extracts of Morus alba that have been used by folk medicine have a great potential to be further developed into a phytomedicine. Morus alba leaves are used in Brazil medicines against fever, to protect the liver, to lower the blood pressure & cholesterol.

   • According to HU Y (2024)

     Excerpt Mulberry (Latin name "Morus alba L.") is a perennial deciduous tree in the family of Moraceae, widely distributed around the world. Polysaccharides, as its main active ingredients, have various effects, such as antioxidant, hypoglycemic, hepatoprotective, & immunomodulatory.

3. 3

   Hepatitis, cirrhosis, fatty liver

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Fauzi A (2024)

     Excerpt On the other hand, administration of 500 & 1000 mg/kg MLE resulted in mild hepatocellular injury, as indicated by a significant (p < 0.05) increase in liver enzyme activities of alanine aminotransferase (ALT) & aspartate aminotransferase (AST). Results: Morus alba leaf depicted total phenolic 10.93 mg gallic acid equivalents (GAE)/g dry weight (DW), flavonoid 256.67 mg quercetin equivalents (QE)/g DW, & antioxidant bioactivity content of 602.03 IC50 μg/mL & 13.21 mg Fe2+/g DW.

   • According to Naowaratwattana W (2010)

     Excerpt The entire plant of Morus alba L. In this study, we investigated the effect of MA leaf extracts on the human hepatoma HepG2 cell line, which is related to hepatocellular carcinoma.

   • According to Zeni ALB (2010)

     Excerpt Therefore, the treatment not only decreased the plasma level of triglycerides but also affected a hepatic enzyme tested supporting the fact that the extracts of Morus alba that have been used by folk medicine have a great potential to be further developed into a phytomedicine. Morus alba leaves are used in Brazil medicines against fever, to protect the liver, to lower the blood pressure & cholesterol.

   • According to HU Y (2024)

     Excerpt Mulberry (Latin name "Morus alba L.") is a perennial deciduous tree in the family of Moraceae, widely distributed around the world. Polysaccharides, as its main active ingredients, have various effects, such as antioxidant, hypoglycemic, hepatoprotective, & immunomodulatory.

   • According to Fathy SA (2013)

     Excerpt this study aimed to investigate the effect of aqueous & organic extracts of mulberry leaves (Morus Alba L.) on human hepatocellular carcinoma HepG2 cell line.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.