Piper betle (Proof) : medicinal properties in alcoholic extraction

Piper betle (Proof, Pepper, Pwèv, Poivre) — family Pipéracées.

Scientific synonyms : Artanthe hexagyna Miq., Betela mastica Raf., Chavica auriculata Miq., C betle (L.) Miq., C chuvya Miq., C densa Miq., C siriboa Miq., Cubeba seriboa Miq., Piper betel Blanco, P rubroglandulosum Chaveer. & Mokkamul, P betlum (L.) St.-Lag..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 30 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 153 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Arambewela LSR (2005)

     Excerpt This was tested in normoglycaemic & streptozotocin (STZ)-induced diabetic rats using oral administration of hot water extract (HWE) & cold ethanolic extract (CEE). Leaves of Piper betle (Piperaceae) possess several bioactivities & are used in traditional medicinal systems.

   • According to Santhaikumari P (2003)

     Excerpt To study the effect of oral administration of Piper betle leaf powder suspension on lipid peroxidation & antioxidants in streptozotocin (STZ) diabetic rats. betle (75 & 150 mg/kg body weight) for 30 days resulted in a significant reduction in plasma thiobarbituric acid reactive substances (TBARS), hydroperoxides, alpha-tocopherol & significant improvement in glutathione, superoxide dismutase, catalase & glutathione peroxidase in the liver & kidney of STZ diabetic rats when compared with untreated diabetic rats.

   • According to Sujatha GH (2011)

     Excerpt Sujatha GH et al, Piper betle Linn: As a Remedy for Diabetes Mellitus, Inter J Res A Pharm, 2(5) 1601-3. 2011- -Sungkatavat P et al, Piper betle extract & its application in bovine teat dipping solution inhibit & eliminate biofilms in bovine mastitis-inducing staphylococci, Vet World, 16(10):2135-42.

   • According to Kumar N (2010)

     Excerpt The leaf extract, fractions & purified compounds are found to play a role in oral hygiene, anti-diabetic, cardiovascular, anti-inflammatory/ immunomodulatory, anti-ulcer, hepato-protective & anti-infective, etc.

   • According to Santhaikumari P (2006)

     Excerpt Santhaikumari P et al, Antihyperglycemic activity of Piper betle leaf on streptozotocin-induced diabetic rats, J Med Food, evaluated the 2006 Spring; 9(1): 108-1-.

2. 2

   Cancer: adjuvant treatment for melanoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shah GA (2018)

     Excerpt After in vivo screening of crude extracts it was concluded that ethyl acetate extract contains some antitumor agents when applied against mice bearing melanoma & depicted significant reduction in tumor size. The present study was carried out to evaluate the anti melanoma activity of Piper betle L.

   • According to Abrahim NN (2012)

     Excerpt Piper betle is a medicinal plant with various biological activities. Due to the current interest in the potential effects of antioxidants from natural products in breast cancer treatment, we investigated the antioxidant activities of the leaves of PB & its inhibitory effect on the proliferation of the breast cancer cell line, MCF-7.

   • According to Del Socorro MML (2014)

     Excerpt In this study, the cytotoxic activity of the methanol, ethanol, & crude aqueous extracts of the plant Betel Vine Piper betle Linn. Hence, PB is found to be containing cytotoxic compounds but this result does not necessarily suggest complete toxicity of the plant because it may also suggest potential antitumor or anticancer activities.

   • According to Banerjee D (2014)

     Excerpt Results: Lung cancer cell line (A549) was tested against four PB leaf extracts ie; aqueous, methanolic, ethyl acetate & petroleum ether for their anti proliferative activity. Conclusions: From the present study it was concluded that the leaf extracts of PB have anti proliferative & chemo preventive potential & can be use for the treatment of various ailments including human lung cancer.

   • According to Paranipe R (2013)

     Excerpt Explored for their unique medicinal properties, the leaves of Piper betel, an evergreen perennial vine, are a reservoir of phenolics with antimutagenic, antitumor & antioxidant activities. Further, the HC containing F2 subfraction was found to be ~8-fold more potent than the F2 subfraction that contained CHV, in human prostate cancer PC-3 cells as evaluated by the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide assay.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to MURUGESAN S (2020)

     Excerpt Betelvine (Piper betle L.) leaves have long been used in Asian countries as a medicine to relieve pain & some metabolic diseases. Rheumatoid Arthritis is a chronic, inflammatory, and systemic autoimmune disease, it affects elders worldwide.

   • According to Reddy PS (2016)

     Excerpt The experimental models of tail-flick method & acetic acid induced writhing were used to study the analgesic activity whereas carrageenan induced paw edema and cotton pellet granuloma models were used for anti-inflammatory action. The analgesic & anti-inflammatory activity of P.betle may be attributed to the presence of various phyto constituents’ viz.

   • According to MAZURA Pisar (n.d.)

     Excerpt Further purification of this fraction revealed hydroxychavicol as the main component involved in its anti-inflammatory activity. Betel vine (Piper betle) is a tropical Asian plant belonging to the family Piperaceae.

   • According to Kumar N (2010)

     Excerpt The leaf extract, fractions & purified compounds are found to play a role in oral hygiene, anti-diabetic, cardiovascular, anti-inflammatory/ immunomodulatory, anti-ulcer, hepato-protective & anti-infective, etc. Patents were also awarded for some of the biological activities like anti-inflammatory, anti-cancer & immunomodulatory associated with leaf extracts&d purified compounds.

   • According to Rintu D (n.d.)

     Excerpt Rintu D et al, Anti-Oxidant and Anti-Inflammatory Activities of Different Varieties of Piper Leaf Extracts (Piper Betle L.), Nutr Food Sci 5:415.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.