Rosmarinus officinalis (Womaren-frans) : medicinal properties in alcoholic extraction

Rosmarinus officinalis (Womaren-frans, French rosemary, romarin de France) — family Lamiacées.

Scientific synonyms : Rosmarinus angustifolius-MR, R communis-N, R flexuosus-J & F, R latifolius-M, R officinalis var angustifolius-(M)-DC, R tenuifolius-J & F, Salvia fasciculata-RF, S Rosmarinus-S.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 179 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Campylobacter jejuni, Salmonella enterica, Bacillus subtilis and Enterococcus faecalis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Yeddes W (2022)

     Excerpt The antibacterial activity of RO essential oil & ethanol extract was determined against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Campylobacter jejuni, Salmonella enterica, Bacillus subtilis & Enterococcus faecalis. The purpose of this study was to determine the chemical composition & antibacterial potential of rosemary essential oil & ethanol extract to improve its physicochemical & antibacterial properties.

   • According to Author (2017)

     Excerpt Monomicrobial biofilms of Candida albicans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans & Pseudomonas aeruginosa & polymicrobial biofilms composed of C. The anti-inflammatory activity was evaluated on RAW 264.7 non-stimulated or stimulated by lipopolysaccharide (LPS) from Escherichia coli & treated with different concentrations of the extract for 24 h.

   • According to da Silva BN (2015)

     Excerpt The chemical composition of Rosmarinus officinalis L. At lower concentrations of REO, the effects on the production of ergosterol & the biomass of mycelium varied, as did the effects on the production of fumonisins, but at ⩾300 μg/mL of REO, these processes were significantly inhibited, showing the effectiveness of the REO as an antifungal agent.

   • According to Bernardes WA (2010)

     Excerpt Antimicrobial activity of Rosmarinus officinalis against oral pathogens: relevance of carnosic acid & carnosol.

   • According to Mothana R.A.A (2011)

     Excerpt & Spach (Compositae) & Rosmarinus officinalis L. The purpose of this study is to evaluate 33 selected Yemeni plants for their in vitro anticancer, antimicrobial, and antioxidant activities.

2. 2

   Cancer: adjuvant treatment for chronic myeloid leukaemia, breast cancer, prostate cancer and glioblastoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Singletary K (1996)

     Excerpt Therefore, carnosol is one RO constituent that can prevent DMBA-induced DNA damage and tumor formation in the rat mammary gland, and, thus, has potential for use as a breast cancer chemopreventive agent. The present studies were conducted in order to evaluate the activity of RO extract, carnosol & ursolic acid in inhibiting the in vivo formation of mammary 7,12-dimethylbenz[a]anthracene (DMBA)-DNA adducts & the initiation of DMBA-induced mammary tumorigenesis in female rats.

   • According to Petiwala SM (2013)

     Excerpt Herein, we describe the in vitro & in vivo studies carried out towards understanding the molecular mechanisms of carnosic acid and carnosol leading to inhibition of prostate cancer. Further work is required to understand its potential for health promotion & potential drug discovery for prostate cancer chemoprevention.

   • According to Kar S (2012)

     Excerpt This study investigates the efficacy of carnosic acid (CA), a polyphenolic diterpene, isolated from Rosmarinus officinalis on androgen-independent human prostate cancer PC-3 cells. In addition, CA induced apoptosis in another androgen refractory prostate cancer DU145 cells via intrinsic pathway as evidenced from the activation of caspase 3, cleavage of PARP, increase in Bax: Bcl-2 ratio and cytochrome-c release.

   • According to Petiwala S.M (2014)

     Excerpt Two human prostate cancer cell lines, 22Rv1 & LNCaP, & prostate epithelial cells procured from two different patients undergoing radical prostatectomy were treated with standardized rosemary extract & evaluated by flow cytometry, MTT, BrdU, Western blot and fluorescent microscopy. In this particular study, a rosemary extract standardized to carnosic acid was evaluated for its potential in disrupting the endoplasmic reticulum machinery to decrease the viability of prostate cancer cells & promote degradation of the androgen receptor.

   • According to González-Vallinas M (2014)

     Excerpt Rosemary (Rosmarinus officinalis L.) extract possesses antitumor properties against tumor cells from several organs, including breast. We found that SFRE exerts antitumor activity against breast cancer cells from different tumor subtypes & the downregulation of ER-α and HER2 receptors by SFRE might be involved in its antitumor effect against estrogen-dependent (ER+) & HER2 overexpressing (HER2+) breast cancer subtypes.

3. 3

   Cencer: adjuvant treatment for epithelial carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pradeep VR (2024)

     Excerpt This study evaluates RO anticancer activity using human epithelial carcinoma (KB) cell lines derived from nasopharyngeal epidermoid carcinoma. The value & use of medicinal plants, including the widespread cultivation of Rosmarinus officinalis, have increased rapidly.

   • According to Petiwala S.M (2014)

     Excerpt Two human prostate cancer cell lines, 22Rv1 & LNCaP, & prostate epithelial cells procured from two different patients undergoing radical prostatectomy were treated with standardized rosemary extract & evaluated by flow cytometry, MTT, BrdU, Western blot and fluorescent microscopy. A significant modulation of endoplasmic reticulum stress proteins was observed in cancer cells while normal prostate epithelial cells did not undergo endoplasmic reticulum stress.

   • According to Oalde-Pavlovic M (2021)

     Excerpt Oalde-Pavlovic M et al, A Study of Phytochemistry, Genoprotective Activity, & Antitumor Effects of Extracts of the Selected Lamiaceae Species, Plants (Basel), 27(11) :2306, 2021-Abstract; This study was designed to evaluate the genoprotective, antigenotoxic, as well as antitumor potential of methanolic, ethanolic, & aqueous extracts of Melissa officinalis, Mentha × piperita, Ocimum basilicum, Rosmarinus officinalis, Salvia officinalis, & Satureja montana (Lamiaceae), in different model systems. The genoprotective potential was tested on pUC19 Escherichia coli XL1-blue, & the anti-genotoxicity on Salmonella typhimurium TA1535/pSK1002 & human lung fibroblasts, while the antitumor activity was assessed on colorectal cancer cells.

   • According to Barni M.V (2012)

     Excerpt The objective of this study was to examine whether carnosic acid (CA), the main antioxidant compound of Rosmarinus officinalis L., would inhibit the cell viability of three CRC cell lines: Caco-2, HT29 é LoVo in a dose-dependent manner, with IC50 values in the range of 24-96 µM. Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide.

   • According to Ahmad HH. (2013)

     Excerpt Methods: In this study, the possible therapeutic effect of rosemary (Rosmarinus officinalis L.) successive methanolic fraction on colorectal cancer induced in experimental animals was studied through several biochemical & molecular genetics analyses as well as histological investigation of colon tissue.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.