Rosmarinus officinalis (Womaren-frans) : vertus médicinales en extraction alcoolique

Rosmarinus officinalis (Womaren-frans, romarin de France, French rosemary) — famille Lamiacées.

Synonymes scientifiques : Rosmarinus angustifolius-MR, R communis-N, R flexuosus-J & F, R latifolius-M, R officinalis var angustifolius-(M)-DC, R tenuifolius-J & F, Salvia fasciculata-RF, S Rosmarinus-S.

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 10 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 179 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Infection bacterienne : Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Campylobacter jejuni, Salmonella enterica, Bacillus subtilis & Enterococcus faecalis

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Yeddes W (2022)

     Extrait The antibacterial activity of RO essential oil & ethanol extract was determined against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Campylobacter jejuni, Salmonella enterica, Bacillus subtilis & Enterococcus faecalis. The purpose of this study was to determine the chemical composition & antibacterial potential of rosemary essential oil & ethanol extract to improve its physicochemical & antibacterial properties.

   • Selon Auteur (2017)

     Extrait Monomicrobial biofilms of Candida albicans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans & Pseudomonas aeruginosa & polymicrobial biofilms composed of C. The anti-inflammatory activity was evaluated on RAW 264.7 non-stimulated or stimulated by lipopolysaccharide (LPS) from Escherichia coli & treated with different concentrations of the extract for 24 h.

   • Selon da Silva BN (2015)

     Extrait The chemical composition of Rosmarinus officinalis L. At lower concentrations of REO, the effects on the production of ergosterol & the biomass of mycelium varied, as did the effects on the production of fumonisins, but at ⩾300 μg/mL of REO, these processes were significantly inhibited, showing the effectiveness of the REO as an antifungal agent.

   • Selon Bernardes WA (2010)

     Extrait Antimicrobial activity of Rosmarinus officinalis against oral pathogens: relevance of carnosic acid & carnosol.

   • Selon Mothana R.A.A (2011)

     Extrait & Spach (Compositae) & Rosmarinus officinalis L. The purpose of this study is to evaluate 33 selected Yemeni plants for their in vitro anticancer, antimicrobial, and antioxidant activities.

2. 2

   Cancer : traitement adjuvant du carcinome leucémique myéloïde chronique, mammaire, prostatique & glioblastome

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Singletary K (1996)

     Extrait Therefore, carnosol is one RO constituent that can prevent DMBA-induced DNA damage and tumor formation in the rat mammary gland, and, thus, has potential for use as a breast cancer chemopreventive agent. The present studies were conducted in order to evaluate the activity of RO extract, carnosol & ursolic acid in inhibiting the in vivo formation of mammary 7,12-dimethylbenz[a]anthracene (DMBA)-DNA adducts & the initiation of DMBA-induced mammary tumorigenesis in female rats.

   • Selon Petiwala SM (2013)

     Extrait Herein, we describe the in vitro & in vivo studies carried out towards understanding the molecular mechanisms of carnosic acid and carnosol leading to inhibition of prostate cancer. Further work is required to understand its potential for health promotion & potential drug discovery for prostate cancer chemoprevention.

   • Selon Kar S (2012)

     Extrait This study investigates the efficacy of carnosic acid (CA), a polyphenolic diterpene, isolated from Rosmarinus officinalis on androgen-independent human prostate cancer PC-3 cells. In addition, CA induced apoptosis in another androgen refractory prostate cancer DU145 cells via intrinsic pathway as evidenced from the activation of caspase 3, cleavage of PARP, increase in Bax: Bcl-2 ratio and cytochrome-c release.

   • Selon Petiwala S.M (2014)

     Extrait Two human prostate cancer cell lines, 22Rv1 & LNCaP, & prostate epithelial cells procured from two different patients undergoing radical prostatectomy were treated with standardized rosemary extract & evaluated by flow cytometry, MTT, BrdU, Western blot and fluorescent microscopy. In this particular study, a rosemary extract standardized to carnosic acid was evaluated for its potential in disrupting the endoplasmic reticulum machinery to decrease the viability of prostate cancer cells & promote degradation of the androgen receptor.

   • Selon González-Vallinas M (2014)

     Extrait Rosemary (Rosmarinus officinalis L.) extract possesses antitumor properties against tumor cells from several organs, including breast. We found that SFRE exerts antitumor activity against breast cancer cells from different tumor subtypes & the downregulation of ER-α and HER2 receptors by SFRE might be involved in its antitumor effect against estrogen-dependent (ER+) & HER2 overexpressing (HER2+) breast cancer subtypes.

3. 3

   Cencer : traitement adjuvant du carcinome épithélial

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Pradeep VR (2024)

     Extrait This study evaluates RO anticancer activity using human epithelial carcinoma (KB) cell lines derived from nasopharyngeal epidermoid carcinoma. The value & use of medicinal plants, including the widespread cultivation of Rosmarinus officinalis, have increased rapidly.

   • Selon Petiwala S.M (2014)

     Extrait Two human prostate cancer cell lines, 22Rv1 & LNCaP, & prostate epithelial cells procured from two different patients undergoing radical prostatectomy were treated with standardized rosemary extract & evaluated by flow cytometry, MTT, BrdU, Western blot and fluorescent microscopy. A significant modulation of endoplasmic reticulum stress proteins was observed in cancer cells while normal prostate epithelial cells did not undergo endoplasmic reticulum stress.

   • Selon Oalde-Pavlovic M (2021)

     Extrait Oalde-Pavlovic M et al, A Study of Phytochemistry, Genoprotective Activity, & Antitumor Effects of Extracts of the Selected Lamiaceae Species, Plants (Basel), 27(11) :2306, 2021-Abstract; This study was designed to evaluate the genoprotective, antigenotoxic, as well as antitumor potential of methanolic, ethanolic, & aqueous extracts of Melissa officinalis, Mentha × piperita, Ocimum basilicum, Rosmarinus officinalis, Salvia officinalis, & Satureja montana (Lamiaceae), in different model systems. The genoprotective potential was tested on pUC19 Escherichia coli XL1-blue, & the anti-genotoxicity on Salmonella typhimurium TA1535/pSK1002 & human lung fibroblasts, while the antitumor activity was assessed on colorectal cancer cells.

   • Selon Barni M.V (2012)

     Extrait The objective of this study was to examine whether carnosic acid (CA), the main antioxidant compound of Rosmarinus officinalis L., would inhibit the cell viability of three CRC cell lines: Caco-2, HT29 é LoVo in a dose-dependent manner, with IC50 values in the range of 24-96 µM. Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. (2013) — extrait : Methods: In this study, the possible therapeutic effect of rosemary (Rosmarinus officinalis L.) successive methanolic fraction on colorectal cancer induced in experimental animals was studied through several biochemical & molecular genetics analyses as well as histological investigation of colon tissue. Conclusion: Thus, it could be concluded that RO has a promising therapeutic effect against colorectal cancer induced in experimental animals through its apoptotic, anti-inflammatory, & antiproliferative effects.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.