Salvia officinalis (Sôj) : medicinal properties in alcoholic extraction

Salvia officinalis (Sôj, Sage, Sauge) — family Lamiacées.

Scientific synonyms : Oboskon cretica (L.) Raf., Salvia chromatica Hoffmanns., S clusii Vilm., S cretica Linn., S crispa Ten., S digna Stokes.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 212 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Isoniazid (INH)-induced hepatotoxicity: normalisation of serum parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT),

   Plant part used: Aerial Parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shahrzad K (2014)

     Excerpt Serum levels of aspartate aminotransferase, alanine transferase & alkaline phosphates in rats coadminstered with both isoniazid (INH) 50 mg/kg & SO extract at 250 mg/kg showed significant reduction when compared to INH group, but administration of SO extract 250 mg/kg alone & with INH has alleviated gamma-glutamyl transferase comparing to INH receiving rats. The antioxidant effects of Salvia officinalis L.

   • According to Amin A, (2005)

     Excerpt In addition, these herbs blocked the induced elevated levels of alanine aminotransferase & aspartate aminotransferase in serum. This escalates levels of alanine aminotransferase, & aspartate aminotransferase in serum.

   • According to Lima CF (2005)

     Excerpt In this study, we evaluate the biosafety & bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L.) in vivo in mice & rats by quantification of plasma transaminase activities and liver glutathione-S-transferase (GST) & glutathione reductase (GR) enzyme activities. When these hepatocyte cultures were exposed to 0.75 or 1mM of tert-butyl hydroperoxide (t-BHP) for 1h, some protection against lipid peroxidation & GSH depletion was conferred by sage tea drinking.

   • According to Hubbert (2006)

     Excerpt The therapeutically active principle is a Salvia Officinalis leaf fluid extract (1:1, extraction solvent ethanol 70% V/V). A randomised double-blind placebo-controlled clinical trial with 67 hyperlipidemic (hypercholesterolemic and/or hyper-triglyceridemic) patients, the effects of taking SO leaf extract (one 500 mg capsule every 8 hours for 2 months, capsules prepared as in Kianbakht & Dabaghian (2013)) on fasting blood levels of lipids, creatinine & liver enzymes were evaluated in 34 patients & compared with the placebo group (n=33).

   • According to Mohammed HA (n.d.)

     Excerpt Current investigations exhibited the effects of extended dryings of the herb on the yields, composition, oil quality, & hepatoprotective as well as anti-cancer biological activities of the hydrodistillation-obtained EO from the aerial parts of the plant. Sage, Salvia officinalis L., is used worldwide as an aromatic herb for culinary purposes as well as a traditional medicinal agent for various ailments.

2. 2

   Abnormal serum levels: ALT, ASP, ALT, CAT, GSH, GST, SOD, MDA

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Amin A, (2005)

     Excerpt To our knowledge, this report is the first that shows hepatoprotective effects of Hibiscus, Rosmarinus & Salvia species against Azathioprine-induced acute liver damage. Typically, administration of Azathioprine induces oxidative stress through depleting the activities of antioxidants & elevating the level of malondialdehyde in liver.

   • According to Shahrzad K (2014)

     Excerpt The antioxidant effects of Salvia officinalis L. Serum levels of aspartate aminotransferase, alanine transferase & alkaline phosphates in rats coadminstered with both isoniazid (INH) 50 mg/kg & SO extract at 250 mg/kg showed significant reduction when compared to INH group, but administration of SO extract 250 mg/kg alone & with INH has alleviated gamma-glutamyl transferase comparing to INH receiving rats.

   • According to Lima CF (2005)

     Excerpt In this study, we evaluate the biosafety & bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L.) in vivo in mice & rats by quantification of plasma transaminase activities and liver glutathione-S-transferase (GST) & glutathione reductase (GR) enzyme activities. This study indicates that the compounds present in this sage preparation contain interesting bioactivities, which improve the liver antioxidant potential.

   • According to Oboh G (2009)

     Excerpt Oboh G et al, Antioxidant & inhibitory effects of aqueous extracts of Salvia officinalis leaves on pro-oxidant- induced lipid peroxidation in brain & liver in vitro.

   • According to Mohammed HA (n.d.)

     Excerpt A notable increase in the viability of the cells, & total antioxidant capacity (TAOxC) levels, together with the reduction in malondialdehyde (MDA) levels were observed by the EOs obtained from all the batches as compared with the AAP-treated cell-lines, HepG-2, HeLa, & MCF-7, that indicated the in vitro hepatoprotective effects of the sage essential oils. The in vivo hepatoprotective activity demonstrated significant reductions in the levels of AST, ALT, & ALP, as well as a significant increase in the total protein (p < 0.05) contents level, as compared to the acetaminophen (AAP) administered experimental group of rats.

3. 3

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Al-Alharbi YM (2022)

     Excerpt There was a negative group (G1); the positive group (G2) received a single dose (50 mg kg), of streptozotocin (STZ) by intraperitoneal injection (i.p.); in G3, diabetic rats (DRs) orally received 5 mL FCM kg−1 daily; in G4, DRs orally received 50 mg GAE SOHE kg−1 daily; in G5, DRs orally received 5 mL FCM contains 25 mg GAE SOHE kg−1 daily; in G6, DRs orally received 5 mL FCM contains 50 mg GAE SOHE kg−1 daily; in G7, DRs orally received 50 mg metformin kg−1 daily. Antioxidative, antidiabetic, & hypolipidemic properties of probiotic-enriched fermented camel milk (FCM) combined with Salvia officinalis L.

   • According to Kashan KT (2015)

     Excerpt The study was undertaken to investigate the effect of aqueous & ethanolic extracts of Sage (Salvia officinalis L) leaves at concentration (100) mg/kg in dosage on albino rats for 14 days, on blood glucose, serum cholesterol & triglycerides (TG) level in induced-diabetic rats by alloxan (150) mg/kg compared with the reference drug Glibenclamide, Also, an evaluation of the active commercially available Sage Oil was analyzed by TLC. Results showed significant reduction (P< 0.05) of fasting blood glucose level in alloxan-induced diabetic rats’ treatment with plant extracts & Glibenclamide drug as compared with infected control group.

   • According to Shafiee-Nick R (2012)

     Excerpt The effects of a polyherbal compound, containing six plants (Allium sativum, Cinnamomum zeylanicum, Nigella sativa, Punica granatum, Salvia officinalis & Teucrium polium) were tested on biochemical parameters in streptozotocin-induced diabetic rats. In conclusion, the MSEC inhibited the progression of hyperglycemia & decreased serum lipids and hepatic enzyme activity in diabetic rats.

   • According to Ben Khedher MR (n.d.)

     Excerpt We investigated possible anti-diabetic, anti-inflammatory & anti-obesity effects of sage methanol (MetOH) extract in a nutritional mouse model of obesity, inflammation & insulin resistance, as well as its effects on lipolysis & lipogenesis in 3T3-L1 cells. Salvia officinalis (sage) is a native plant to the Mediterranean region & has been used for a long time in traditional medicine for various diseases.

   • According to Eidi M (2005)

     Excerpt To determine the hypoglycaemic effect of SO leaves, we investigated the effects of essential oil & methanolic effect of the plant on healthy & streptozotocin-induced diabetic rats. The results showed that the EO of sage did not change serum glucose, while the plant extract significantly decreased serum glucose in diabetic rats in 3h without effect on insulin releasing from the pancreas but not in healthy rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.