Salvia officinalis (Sôj) : vertus médicinales en extraction alcoolique

Salvia officinalis (Sôj, Sauge, Sage) — famille Lamiacées.

Synonymes scientifiques : Oboskon cretica (L.) Raf., Salvia chromatica Hoffmanns., S clusii Vilm., S cretica Linn., S crispa Ten., S digna Stokes.

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 17 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 212 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Hépatotoxicité induite par l’Isoniazide(INH) :normalisation des paramètres sériques : aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphates (ALP), gamma-glutamyl transférase (GGT),

   Partie usitée : Parties Aeriennes.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Shahrzad K (2014)

     Extrait Serum levels of aspartate aminotransferase, alanine transferase & alkaline phosphates in rats coadminstered with both isoniazid (INH) 50 mg/kg & SO extract at 250 mg/kg showed significant reduction when compared to INH group, but administration of SO extract 250 mg/kg alone & with INH has alleviated gamma-glutamyl transferase comparing to INH receiving rats. The antioxidant effects of Salvia officinalis L.

   • Selon Amin A, (2005)

     Extrait In addition, these herbs blocked the induced elevated levels of alanine aminotransferase & aspartate aminotransferase in serum. This escalates levels of alanine aminotransferase, & aspartate aminotransferase in serum.

   • Selon Lima CF (2005)

     Extrait In this study, we evaluate the biosafety & bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L.) in vivo in mice & rats by quantification of plasma transaminase activities and liver glutathione-S-transferase (GST) & glutathione reductase (GR) enzyme activities. When these hepatocyte cultures were exposed to 0.75 or 1mM of tert-butyl hydroperoxide (t-BHP) for 1h, some protection against lipid peroxidation & GSH depletion was conferred by sage tea drinking.

   • Selon Hubbert (2006)

     Extrait The therapeutically active principle is a Salvia Officinalis leaf fluid extract (1:1, extraction solvent ethanol 70% V/V). A randomised double-blind placebo-controlled clinical trial with 67 hyperlipidemic (hypercholesterolemic and/or hyper-triglyceridemic) patients, the effects of taking SO leaf extract (one 500 mg capsule every 8 hours for 2 months, capsules prepared as in Kianbakht & Dabaghian (2013)) on fasting blood levels of lipids, creatinine & liver enzymes were evaluated in 34 patients & compared with the placebo group (n=33).

   • Selon Mohammed HA (s.d.)

     Extrait Sage, Salvia officinalis L., is used worldwide as an aromatic herb for culinary purposes as well as a traditional medicinal agent for various ailments. A notable increase in the viability of the cells, & total antioxidant capacity (TAOxC) levels, together with the reduction in malondialdehyde (MDA) levels were observed by the EOs obtained from all the batches as compared with the AAP-treated cell-lines, HepG-2, HeLa, & MCF-7, that indicated the in vitro hepatoprotective effects of the sage essential oils.

2. 2

   Anormalité des paramètres sérique : ALT, ASP, ALT, CAT, GSH, GST, SOD, MDA

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Amin A, (2005)

     Extrait To our knowledge, this report is the first that shows hepatoprotective effects of Hibiscus, Rosmarinus & Salvia species against Azathioprine-induced acute liver damage. Typically, administration of Azathioprine induces oxidative stress through depleting the activities of antioxidants & elevating the level of malondialdehyde in liver.

   • Selon Shahrzad K (2014)

     Extrait The antioxidant effects of Salvia officinalis L. Serum levels of aspartate aminotransferase, alanine transferase & alkaline phosphates in rats coadminstered with both isoniazid (INH) 50 mg/kg & SO extract at 250 mg/kg showed significant reduction when compared to INH group, but administration of SO extract 250 mg/kg alone & with INH has alleviated gamma-glutamyl transferase comparing to INH receiving rats.

   • Selon Lima CF (2005)

     Extrait In this study, we evaluate the biosafety & bioactivity (antioxidant potential) of a traditional water infusion (tea) of common sage (Salvia officinalis L.) in vivo in mice & rats by quantification of plasma transaminase activities and liver glutathione-S-transferase (GST) & glutathione reductase (GR) enzyme activities. This study indicates that the compounds present in this sage preparation contain interesting bioactivities, which improve the liver antioxidant potential.

   • Selon Oboh G (2009)

     Extrait Oboh G et al, Antioxidant & inhibitory effects of aqueous extracts of Salvia officinalis leaves on pro-oxidant- induced lipid peroxidation in brain & liver in vitro.

   • Selon Mohammed HA (s.d.)

     Extrait A notable increase in the viability of the cells, & total antioxidant capacity (TAOxC) levels, together with the reduction in malondialdehyde (MDA) levels were observed by the EOs obtained from all the batches as compared with the AAP-treated cell-lines, HepG-2, HeLa, & MCF-7, that indicated the in vitro hepatoprotective effects of the sage essential oils. The in vivo hepatoprotective activity demonstrated significant reductions in the levels of AST, ALT, & ALP, as well as a significant increase in the total protein (p < 0.05) contents level, as compared to the acetaminophen (AAP) administered experimental group of rats.

3. 3

   Diabète mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Glibenclamide-like, Metformine-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Al-Alharbi YM (2022)

     Extrait There was a negative group (G1); the positive group (G2) received a single dose (50 mg kg), of streptozotocin (STZ) by intraperitoneal injection (i.p.); in G3, diabetic rats (DRs) orally received 5 mL FCM kg−1 daily; in G4, DRs orally received 50 mg GAE SOHE kg−1 daily; in G5, DRs orally received 5 mL FCM contains 25 mg GAE SOHE kg−1 daily; in G6, DRs orally received 5 mL FCM contains 50 mg GAE SOHE kg−1 daily; in G7, DRs orally received 50 mg metformin kg−1 daily. Antioxidative, antidiabetic, & hypolipidemic properties of probiotic-enriched fermented camel milk (FCM) combined with Salvia officinalis L.

   • Selon Kashan KT (2015)

     Extrait The study was undertaken to investigate the effect of aqueous & ethanolic extracts of Sage (Salvia officinalis L) leaves at concentration (100) mg/kg in dosage on albino rats for 14 days, on blood glucose, serum cholesterol & triglycerides (TG) level in induced-diabetic rats by alloxan (150) mg/kg compared with the reference drug Glibenclamide, Also, an evaluation of the active commercially available Sage Oil was analyzed by TLC. Results showed significant reduction (P< 0.05) of fasting blood glucose level in alloxan-induced diabetic rats’ treatment with plant extracts & Glibenclamide drug as compared with infected control group.

   • Selon Shafiee-Nick R (2012)

     Extrait The effects of a polyherbal compound, containing six plants (Allium sativum, Cinnamomum zeylanicum, Nigella sativa, Punica granatum, Salvia officinalis & Teucrium polium) were tested on biochemical parameters in streptozotocin-induced diabetic rats. In conclusion, the MSEC inhibited the progression of hyperglycemia & decreased serum lipids and hepatic enzyme activity in diabetic rats.

   • Selon Ben Khedher MR (s.d.)

     Extrait We investigated possible anti-diabetic, anti-inflammatory & anti-obesity effects of sage methanol (MetOH) extract in a nutritional mouse model of obesity, inflammation & insulin resistance, as well as its effects on lipolysis & lipogenesis in 3T3-L1 cells. Salvia officinalis (sage) is a native plant to the Mediterranean region & has been used for a long time in traditional medicine for various diseases.

   • Selon Eidi M (2005)

     Extrait To determine the hypoglycaemic effect of SO leaves, we investigated the effects of essential oil & methanolic effect of the plant on healthy & streptozotocin-induced diabetic rats. The results showed that the EO of sage did not change serum glucose, while the plant extract significantly decreased serum glucose in diabetic rats in 3h without effect on insulin releasing from the pancreas but not in healthy rats.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.