Senna spectabilis (Kanéfis) : medicinal properties in alcoholic extraction

Senna spectabilis (Kanéfis) — family Fabacées.

Scientific synonyms : Cassia spectabilis-DC, C excelsa-Schrad, C carnaval-Speg, Pseudocassia spectabilis-(DC)-Br & Rose.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 5 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 50 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Machado Pereira R (2016)

     Excerpt Therefore, they represent promise antitumor compounds against liver cancer & should be considered for further anticancer in vivo studies. Herein, we aimed to investigate in vitro antiproliferative & cytotoxic potentials of an alkaloid mixture derived from Senna spectabilis, (−)-cassine (1) & (−)-spectaline (2).

   • According to Subramanian L (2012)

     Excerpt In the present study, in vitro antioxidant, free radical scavenging capacity, & hepatoprotective activity of methanol extracts from Polyalthia longifolia & Cassia spectabilis were evaluated using established in vitro models such as ferric-reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl , hydroxyl radical , nitric oxide radical scavenging, metal chelating, & antilipid peroxidation activities. longifolia leaf extract could protect the liver against paracetamol-induced oxidative damage by possibly increasing the antioxidant protection mechanism in mice.

   • According to Jothy SL (2012)

     Excerpt In the present study, in vitro antioxidant, free radical scavenging capacity, & hepatoprotective activity of methanol extracts from Polyalthia longifolia & Cassia spectabilis were evaluated using established in vitro models such as ferric-reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH (•)), hydroxyl radical (OH (•)), nitric oxide radical (NO (•)) scavenging, metal chelating, & antilipid peroxidation activities. Results revealed that PL leaf extract could protect the liver against paracetamol-induced oxidative damage by possibly increasing the antioxidant protection mechanism in mice.

   • According to Shridhari NB (2007)

     Excerpt To assess the toxic nature of the plant Cassia spectabilis, male crossbred cow calves were fed 20, 40 or 60 g/kg leaves of CS for 5 days. Degenerative changes were noted in liver & myocardium.

   • According to da Silva KA (2012)

     Excerpt in this study, the anti-nociceptive & anti-inflammatory effects of (-)-cassine, isolated from Senna spectabilis were evaluated using pharmacological, behavioural & biochemical approaches. Additionally, oral treatment with (-)-cassine (3-60 mg/kg) prevented the mechanical hyperalgesia elicited by intraplantar injection of prostaglandin E (2), complete Freund's adjuvant, interleukin-1β, interleukin-6 & keratinocyte-derived chemokine.

2. 2

   Malaria: Plasmodium falciparum

   Plant part used: Pest control and veterinary products.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pivatto M (1900)

     Excerpt n our continuing work looking for new anti-infective lead compounds from Brazilian biomes, the two known piperidine alkaloids ( - )-cassine & ( - )-spectaline were isolated from the flowers of Senna spectabilis (syn. These data show that piperidine alkaloids constitute a class of natural products that feature a broad spectrum of biological activities, & are, therefore, important templates for drug design, including antimalarial.

   • According to Bawasi W (2020)

     Excerpt Cassia spectabilis DC leaf has shown a good antimalarial activity. berghei mice obtained the highest dose of inhibition percentage of 90% ethanol extract of CS leaf was 68.61% while positive (doxycycline) control at 100 mg kg-1 was 73.54%.

   • According to Ekasari W (n.d.)

     Excerpt this study is a follow-up study of leaf activity & mechanism of Cassia spectabilis DC as an antimalarial. berghei mice obtained the highest dose of inhibition percentage of 90% ethanol extract of CS Leaf was 68.61% while positive (doxycycline) control at 100 mg kg-1 was 73.54%.

   • According to Muniz de Albuquerque Melo G (2014)

     Excerpt Senna spectabilis (sin. In folk medicine, this plant is indicated for the treatment of constipation, insomnia, anxiety, epilepsy, malaria, dysentery & headache.

   • According to Rodrigues-Freitas T (2022)

     Excerpt Our study aims to evaluate whether (–)-cassine (1) & (–)-spectaline (2), the main alkaloids of Senna spectabilis, display anti-CHIKV activity. Both compounds have been described to be biologically active against neglected tropical diseases, including malaria, leishmaniasis, & schistosomiasis, which emphasizes that these molecules could be repurposed for chikungunya fever treatment.

3. 3

   Leishmaniasis: Leishmania major

   Plant part used: Pest control and veterinary products.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sain AA (2017)

     Excerpt n this study, antileishmanial properties from the constituents of a medicinal plant, Senna spectabilis were investigated using in vitro antileishmanial assays which were the first one established in Malaysia. The finding from this work hopefully will aid the drug development efforts for leishmaniasis treatment.

   • According to Muniz de Albuquerque Melo G (2014)

     Excerpt Fractions dichloromethane (FL-DCM) & n-butanol (FL-Bu) & a mixture of (−)-cassine/(−)-spectaline (∼7:3) exhibited significant activity against the parasite Leishmania major (IC50values of 0.6 ± 0.1 μg/ml, 1.6 ± 0.9 μg/ml and 24.9 ± 1.4 μg/ml, respectively), without toxic effects on murine macrophages. The growth inhibitory effect of promastigote forms of Leishmania major was determined for the crude extract, fractions of the flowers of S.

   • According to Lacerda RBM (2018)

     Excerpt Many natural products, particularly alkaloids, have been reported to have inhibitory activity against arginase, the key enzyme in the pathology caused by Leishmania sp. In this way, piperidine alkaloids (–)-cassine (1), (–)-spectaline (2), (–)-3-O-acetylcassine (3), and (–)-3-O-acetylspectaline (4) were isolated from Senna spectabilis flowers.

   • According to Rodrigues-Freitas T (2022)

     Excerpt Our study aims to evaluate whether (–)-cassine (1) & (–)-spectaline (2), the main alkaloids of Senna spectabilis, display anti-CHIKV activity. Both compounds have been described to be biologically active against neglected tropical diseases, including malaria, leishmaniasis, & schistosomiasis, which emphasizes that these molecules could be repurposed for chikungunya fever treatment.

   • According to Sangeetha S (2009)

     Excerpt The inhibitory effect of Cassia spectabilis methanol leaf extract was evaluated against biofilm forming Candida albicans, which was sensitive to 6.25 mg/ml concentration of the extract. The significant antifungal activity shown by this methanol extract of Cs suggests its potential against infections caused by C.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.