Senna spectabilis (Kanéfis) : propiedades medicinales en extracción alcohólica

Senna spectabilis (Kanéfis) — familia Fabacées.

Sinónimos científicos : Cassia spectabilis-DC, C excelsa-Schrad, C carnaval-Speg, Pseudocassia spectabilis-(DC)-Br & Rose.

Esta base documenta las extracciones alcohólicas (etanol) de las sustancias activas. Nuestra monografía recoge actualmente 5 indicaciones en extracción alcohólica para esta especie. El catálogo Lapo v2 registra 50 referencias científicas para esta especie (detalle completo en la aplicación).

Indicaciones terapéuticas en extracción alcohólica:

Importante — referencias científicas en esta página pública: solo se muestra un breve extracto de cada fuente citada (frases de resumen seleccionadas), conservado en el idioma original de la publicación (casi siempre el inglés), sin traducir. Estos extractos no constituyen el texto íntegro del artículo ni una bibliografía completa. Las fichas de referencia completas y el detalle monográfico están disponibles en la aplicación Lapo v2 (prueba gratuita de 30 días).

1. 1

   Cáncer: tratamiento adyuvante del carcinoma hepático

   Parte usada: flor.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Machado Pereira R (2016)

     Extrait Therefore, they represent promise antitumor compounds against liver cancer & should be considered for further anticancer in vivo studies. Herein, we aimed to investigate in vitro antiproliferative & cytotoxic potentials of an alkaloid mixture derived from Senna spectabilis, (−)-cassine (1) & (−)-spectaline (2).

   • Selon Subramanian L (2012)

     Extrait In the present study, in vitro antioxidant, free radical scavenging capacity, & hepatoprotective activity of methanol extracts from Polyalthia longifolia & Cassia spectabilis were evaluated using established in vitro models such as ferric-reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl , hydroxyl radical , nitric oxide radical scavenging, metal chelating, & antilipid peroxidation activities. longifolia leaf extract could protect the liver against paracetamol-induced oxidative damage by possibly increasing the antioxidant protection mechanism in mice.

   • Selon Jothy SL (2012)

     Extrait In the present study, in vitro antioxidant, free radical scavenging capacity, & hepatoprotective activity of methanol extracts from Polyalthia longifolia & Cassia spectabilis were evaluated using established in vitro models such as ferric-reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH (•)), hydroxyl radical (OH (•)), nitric oxide radical (NO (•)) scavenging, metal chelating, & antilipid peroxidation activities. Results revealed that PL leaf extract could protect the liver against paracetamol-induced oxidative damage by possibly increasing the antioxidant protection mechanism in mice.

   • Selon Shridhari NB (2007)

     Extrait To assess the toxic nature of the plant Cassia spectabilis, male crossbred cow calves were fed 20, 40 or 60 g/kg leaves of CS for 5 days. Degenerative changes were noted in liver & myocardium.

   • Selon da Silva KA (2012)

     Extrait in this study, the anti-nociceptive & anti-inflammatory effects of (-)-cassine, isolated from Senna spectabilis were evaluated using pharmacological, behavioural & biochemical approaches. Additionally, oral treatment with (-)-cassine (3-60 mg/kg) prevented the mechanical hyperalgesia elicited by intraplantar injection of prostaglandin E (2), complete Freund's adjuvant, interleukin-1β, interleukin-6 & keratinocyte-derived chemokine.

2. 2

   Malaria: Plasmodium falciparum

   Parte usada: Parasiticida y veterinario.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Pivatto M (1900)

     Extrait n our continuing work looking for new anti-infective lead compounds from Brazilian biomes, the two known piperidine alkaloids ( - )-cassine & ( - )-spectaline were isolated from the flowers of Senna spectabilis (syn. falciparum-infected red blood cells (RBC) in culture, aiming to identify antimalarial prototypes.

   • Selon Bawasi W (2020)

     Extrait Cassia spectabilis DC leaf has shown a good antimalarial activity. In antimalarial testing in combination with artesunate, it was found that administering 150 mg kg-1 (three times a day) of CS (D0 − D2) + artesunate (D2) was better than the standard combination of amodiaquine + artesunate with 99.18% & 92.88% inhibition percentage.

   • Selon Ekasari W (s.d.)

     Extrait this study is a follow-up study of leaf activity & mechanism of Cassia spectabilis DC as an antimalarial. In antimalarial testing in combination with artesunate, it was found that administering 150 mg kg-1 (three times a day) of CS (D0 − D2) + artesunate (D2) was better than the standard combination of amodiaquine + artesunate with 99.18% & 92.88% inhibition percentage.

   • Selon Muniz de Albuquerque Melo G (2014)

     Extrait Senna spectabilis (sin. In folk medicine, this plant is indicated for the treatment of constipation, insomnia, anxiety, epilepsy, malaria, dysentery & headache.

   • Selon Rodrigues-Freitas T (2022)

     Extrait Our study aims to evaluate whether (–)-cassine (1) & (–)-spectaline (2), the main alkaloids of Senna spectabilis, display anti-CHIKV activity. Both compounds have been described to be biologically active against neglected tropical diseases, including malaria, leishmaniasis, & schistosomiasis, which emphasizes that these molecules could be repurposed for chikungunya fever treatment.

3. 3

   Leishmaniasis: Leishmania major

   Parte usada: Parasiticida y veterinario.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Sain AA (2017)

     Extrait n this study, antileishmanial properties from the constituents of a medicinal plant, Senna spectabilis were investigated using in vitro antileishmanial assays which were the first one established in Malaysia. The finding from this work hopefully will aid the drug development efforts for leishmaniasis treatment.

   • Selon Muniz de Albuquerque Melo G (2014)

     Extrait Fractions dichloromethane (FL-DCM) & n-butanol (FL-Bu) & a mixture of (−)-cassine/(−)-spectaline (∼7:3) exhibited significant activity against the parasite Leishmania major (IC50values of 0.6 ± 0.1 μg/ml, 1.6 ± 0.9 μg/ml and 24.9 ± 1.4 μg/ml, respectively), without toxic effects on murine macrophages. The growth inhibitory effect of promastigote forms of Leishmania major was determined for the crude extract, fractions of the flowers of S.

   • Selon Lacerda RBM (2018)

     Extrait In this way, piperidine alkaloids (–)-cassine (1), (–)-spectaline (2), (–)-3-O-acetylcassine (3), and (–)-3-O-acetylspectaline (4) were isolated from Senna spectabilis flowers. Many natural products, particularly alkaloids, have been reported to have inhibitory activity against arginase, the key enzyme in the pathology caused by Leishmania sp.

   • Selon Rodrigues-Freitas T (2022)

     Extrait Our study aims to evaluate whether (–)-cassine (1) & (–)-spectaline (2), the main alkaloids of Senna spectabilis, display anti-CHIKV activity. Both compounds have been described to be biologically active against neglected tropical diseases, including malaria, leishmaniasis, & schistosomiasis, which emphasizes that these molecules could be repurposed for chikungunya fever treatment.

   • Selon Sangeetha S (2009)

     Extrait The inhibitory effect of Cassia spectabilis methanol leaf extract was evaluated against biofilm forming Candida albicans, which was sensitive to 6.25 mg/ml concentration of the extract. The significant antifungal activity shown by this methanol extract of Cs suggests its potential against infections caused by C.

Otras indicaciones (incluidos otros modos de extracción si procede), posologías, precauciones de uso y las <strong>referencias científicas completas</strong> (fichas íntegras, no solo los extractos cortos anteriores) están disponibles en la ficha monográfica de la aplicación Lapo v2.