Senna spectabilis (Kanéfis) : vertus médicinales en extraction alcoolique

Senna spectabilis (Kanéfis) — famille Fabacées.

Synonymes scientifiques : Cassia spectabilis-DC, C excelsa-Schrad, C carnaval-Speg, Pseudocassia spectabilis-(DC)-Br & Rose.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 5 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 50 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome hépatique

   Partie usitée : Fleur.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Machado Pereira R (2016)

     Extrait Therefore, they represent promise antitumor compounds against liver cancer & should be considered for further anticancer in vivo studies. Herein, we aimed to investigate in vitro antiproliferative & cytotoxic potentials of an alkaloid mixture derived from Senna spectabilis, (−)-cassine (1) & (−)-spectaline (2).

   • Selon Subramanian L (2012)

     Extrait In the present study, in vitro antioxidant, free radical scavenging capacity, & hepatoprotective activity of methanol extracts from Polyalthia longifolia & Cassia spectabilis were evaluated using established in vitro models such as ferric-reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl , hydroxyl radical , nitric oxide radical scavenging, metal chelating, & antilipid peroxidation activities. longifolia leaf extract could protect the liver against paracetamol-induced oxidative damage by possibly increasing the antioxidant protection mechanism in mice.

   • Selon Jothy SL (2012)

     Extrait In the present study, in vitro antioxidant, free radical scavenging capacity, & hepatoprotective activity of methanol extracts from Polyalthia longifolia & Cassia spectabilis were evaluated using established in vitro models such as ferric-reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH (•)), hydroxyl radical (OH (•)), nitric oxide radical (NO (•)) scavenging, metal chelating, & antilipid peroxidation activities. Results revealed that PL leaf extract could protect the liver against paracetamol-induced oxidative damage by possibly increasing the antioxidant protection mechanism in mice.

   • Selon Shridhari NB (2007)

     Extrait To assess the toxic nature of the plant Cassia spectabilis, male crossbred cow calves were fed 20, 40 or 60 g/kg leaves of CS for 5 days. Degenerative changes were noted in liver & myocardium.

   • Selon da Silva KA (2012)

     Extrait in this study, the anti-nociceptive & anti-inflammatory effects of (-)-cassine, isolated from Senna spectabilis were evaluated using pharmacological, behavioural & biochemical approaches. Additionally, oral treatment with (-)-cassine (3-60 mg/kg) prevented the mechanical hyperalgesia elicited by intraplantar injection of prostaglandin E (2), complete Freund's adjuvant, interleukin-1β, interleukin-6 & keratinocyte-derived chemokine.

2. 2

   Paludisme : Plasmodium falciparum

   Partie usitée : Parasiticide et vétérinaire. Profil pharmacologique documenté : Artésunate-like, Amodiaquine-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Pivatto M (1900)

     Extrait n our continuing work looking for new anti-infective lead compounds from Brazilian biomes, the two known piperidine alkaloids ( - )-cassine & ( - )-spectaline were isolated from the flowers of Senna spectabilis (syn. falciparum-infected red blood cells (RBC) in culture, aiming to identify antimalarial prototypes.

   • Selon Bawasi W (2020)

     Extrait Cassia spectabilis DC leaf has shown a good antimalarial activity. In antimalarial testing in combination with artesunate, it was found that administering 150 mg kg-1 (three times a day) of CS (D0 − D2) + artesunate (D2) was better than the standard combination of amodiaquine + artesunate with 99.18% & 92.88% inhibition percentage.

   • Selon Ekasari W (s.d.)

     Extrait this study is a follow-up study of leaf activity & mechanism of Cassia spectabilis DC as an antimalarial. In antimalarial testing in combination with artesunate, it was found that administering 150 mg kg-1 (three times a day) of CS (D0 − D2) + artesunate (D2) was better than the standard combination of amodiaquine + artesunate with 99.18% & 92.88% inhibition percentage.

   • Selon Muniz de Albuquerque Melo G (2014)

     Extrait Senna spectabilis (sin. In folk medicine, this plant is indicated for the treatment of constipation, insomnia, anxiety, epilepsy, malaria, dysentery & headache.

   • Selon Rodrigues-Freitas T (2022)

     Extrait Our study aims to evaluate whether (–)-cassine (1) & (–)-spectaline (2), the main alkaloids of Senna spectabilis, display anti-CHIKV activity. Both compounds have been described to be biologically active against neglected tropical diseases, including malaria, leishmaniasis, & schistosomiasis, which emphasizes that these molecules could be repurposed for chikungunya fever treatment.

3. 3

   Leishmaniose : Leishmania major

   Partie usitée : Parasiticide et vétérinaire.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Sain AA (2017)

     Extrait n this study, antileishmanial properties from the constituents of a medicinal plant, Senna spectabilis were investigated using in vitro antileishmanial assays which were the first one established in Malaysia. The finding from this work hopefully will aid the drug development efforts for leishmaniasis treatment.

   • Selon Muniz de Albuquerque Melo G (2014)

     Extrait Fractions dichloromethane (FL-DCM) & n-butanol (FL-Bu) & a mixture of (−)-cassine/(−)-spectaline (∼7:3) exhibited significant activity against the parasite Leishmania major (IC50values of 0.6 ± 0.1 μg/ml, 1.6 ± 0.9 μg/ml and 24.9 ± 1.4 μg/ml, respectively), without toxic effects on murine macrophages. The growth inhibitory effect of promastigote forms of Leishmania major was determined for the crude extract, fractions of the flowers of S.

   • Selon Lacerda RBM (2018)

     Extrait In this way, piperidine alkaloids (–)-cassine (1), (–)-spectaline (2), (–)-3-O-acetylcassine (3), and (–)-3-O-acetylspectaline (4) were isolated from Senna spectabilis flowers. Many natural products, particularly alkaloids, have been reported to have inhibitory activity against arginase, the key enzyme in the pathology caused by Leishmania sp.

   • Selon Rodrigues-Freitas T (2022)

     Extrait Our study aims to evaluate whether (–)-cassine (1) & (–)-spectaline (2), the main alkaloids of Senna spectabilis, display anti-CHIKV activity. Both compounds have been described to be biologically active against neglected tropical diseases, including malaria, leishmaniasis, & schistosomiasis, which emphasizes that these molecules could be repurposed for chikungunya fever treatment.

   • Selon Sangeetha S (2009)

     Extrait The inhibitory effect of Cassia spectabilis methanol leaf extract was evaluated against biofilm forming Candida albicans, which was sensitive to 6.25 mg/ml concentration of the extract. The significant antifungal activity shown by this methanol extract of Cs suggests its potential against infections caused by C.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.