Sorghum bicolor (Sorghum) : medicinal properties in alcoholic extraction

Sorghum bicolor (Sorghum, Sorgho) — family Poacées.

Scientific synonyms : Agrostis nigricans (Ruiz & Pav.) Poir., Andropogon besseri Kunth, A caffrorum (Thunb.) Kunth, A compactus Brot., A dulcis Burm.f., A niger (Ard.) Kunth.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 164 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Sound.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Zhu Y (2017)

     Excerpt Hepatocellular carcinoma is the fifth frequently diagnosed cancer in humans. Stronger anti-proliferation & inhibition of cell migration (p <.05) in HepG2 cancer cells were also demonstrated among the PRE samples from Jinza No.

   • According to Ogunka-Nnoka CU (2012)

     Excerpt Toxicity profile on serum electrolytes, hepatic & renal function indices on rats administered with mixture of ethanol/potash extract of sorghum bicolor leaf sheath were investigated.

   • According to Lee BH (2014)

     Excerpt The lipid fraction of the grain sorghum whole kernel (GS-WK) (i.e., phytosterol rich oil or policosanol rich wax) responsible for lowering cholesterol in hamsters fed the crude lipid (wax + oil) was determined. Although the 5% wax supplement did not affect either plasma or liver cholesterol, excreted neutral sterol and bile acid were slightly higher than produced by the atherogenic diet.

   • According to Kim J (2012)

     Excerpt Kim J et al, Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats.

   • According to Akande IS (2010)

     Excerpt Akande IS et al, Effects of aqueous extract of Sorghum bicolor on hepatic, histological & haematological indices in rats.

2. 2

   Elevated creatinine levels in diabetic patients

   Plant part used: Shaft.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Obika OI (2022)

     Excerpt The creatinine reduction ability was analyzed using Jaffe’s method for clean-catch spot urine samples of normal, diabetic & hypertensive patients. The study investigated the effect of Sorghum bicolor (L.) Moench extract on the renal activity of both normal & ailing patients.

   • According to Chung IM (n.d.)

     Excerpt Hwanggeumchal sorghum phenolic extracts in the streptozotocin-induced diabetic rats showed significant hypoglycemic activity for 14 days & significantly decreased the serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase & alanine amino transferase while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05) (at doses of 100 & 250 mg/kg for 14 days). the present study evaluated the antidiabetic effects from phenolic extracts of three varieties (Hwanggeumchal sorghum, Chal sorghum, & Heuin sorghum) from Korean sorghum (Sorghum bicolor L.

   • According to Kim M (2023)

     Excerpt Sorghum is considered a rich source of bioactive compounds & to reduce the risk of diabetes, whereas metformin (Met) can promote insulin sensitivity & facilitate glucose uptake by cells. In this study, we investigated the anti-diabetic effects of sorghum ethanol extract (SEE), Met, & their combinations (SEE-Met) by measuring glucose consumption by HepG2 cells.

   • According to Kim JS (2011)

     Excerpt It has been suggested that the intake of whole grain foods is beneficial to the prevention & management of diabetes mellitus. These in vitro studies indicate the potential of sorghum in the development of effective anti-diabetic agents,.

   • According to Seneviratne IG (2021)

     Excerpt The present study evaluated a range of biological activities of selected millet types & sorghum varieties in Sri Lanka in relation to diabetes & its complications management. Therefore, consumption of whole grains of pigmented millet & sorghum in Sri Lanka may play an important role in the prevention & management of diabetes & its complications.

3. 3

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kim M (2023)

     Excerpt Sorghum is considered a rich source of bioactive compounds & to reduce the risk of diabetes, whereas metformin (Met) can promote insulin sensitivity & facilitate glucose uptake by cells. In this study, we investigated the anti-diabetic effects of sorghum ethanol extract (SEE), Met, & their combinations (SEE-Met) by measuring glucose consumption by HepG2 cells.

   • According to Obika OI (2022)

     Excerpt The study investigated the effect of Sorghum bicolor (L.) Moench extract on the renal activity of both normal & ailing patients. bicolor at different concentrations showed varying effects on the creatinine concentration, it reduced creatinine level in low doses & has antioxidant properties.

   • According to Kim JS (2011)

     Excerpt It has been suggested that the intake of whole grain foods is beneficial to the prevention & management of diabetes mellitus. These in vitro studies indicate the potential of sorghum in the development of effective anti-diabetic agents,.

   • According to Seneviratne IG (2021)

     Excerpt The present study evaluated a range of biological activities of selected millet types & sorghum varieties in Sri Lanka in relation to diabetes & its complications management. Therefore, consumption of whole grains of pigmented millet & sorghum in Sri Lanka may play an important role in the prevention & management of diabetes & its complications.

   • According to Chung IM (n.d.)

     Excerpt Hwanggeumchal sorghum phenolic extracts in the streptozotocin-induced diabetic rats showed significant hypoglycemic activity for 14 days & significantly decreased the serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase & alanine amino transferase while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05) (at doses of 100 & 250 mg/kg for 14 days). the present study evaluated the antidiabetic effects from phenolic extracts of three varieties (Hwanggeumchal sorghum, Chal sorghum, & Heuin sorghum) from Korean sorghum (Sorghum bicolor L.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.