Syzygium aromaticum (Klou-Jiwôf) : medicinal properties in alcoholic extraction

Syzygium aromaticum (Klou-Jiwôf, Clove, Clou-de-girofle) — family Myrtacées.

Scientific synonyms : Caryophyllus aromaticus L, Eugenia aromatica (L.) Baill, E caryophyllata Thunb, E Caryophyllus (Spreng.) Bullock & S.G. Harrison.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 21 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 144 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: multi-drug resistant (MRSA): Escherichia coli, Klebsiella pneumoniae & Candida albicans. ATCC strains of Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus bovis, Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli and Klebsiella pneumoniae

   Plant part used: Fruit (flower bud).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Khan R (2009)

     Excerpt ATCC strains of Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus bovis, Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae & Candida albicans were also tested. Antimicrobial activities of the crude ethanolic extracts of five plants were screened against multidrug resistant (MDR) strains of Escherichia coli, Klebsiella pneumoniae & Candida albicans.

   • According to Agrawal MK (2016)

     Excerpt Staphylococcus aureus (NCIM 2079), Bacillus subtilis (NCIM 2063), Escherichia coli (NCIM 2065), Salmonella typhimurium (NCIM 2501), Streptococcus pneumoniae (NCIM 5281) & a yeast Candida albicans (NCIM 3471). Ethanolic & aqueous extracts of 20 Indian medicinal plants traditionally used in medicine were studied for their antibacterial & anticandidal activity against five multi – drug resistant bacteria i.

   • According to Yassin MT (2020)

     Excerpt In the current study, the antibacterial efficiency of clove extracts (acetonic, dichloromethane, ethanolic, & petroleum ether) against four pathogenic bacterial strains [Escherichia coli, Salmonella typhi, Staphylococcus aureus & Methicillin-Resistant S aureus (MRSA)] was estimated by disc diffusion method. Results & conclusion: The dichloromethane extract presented the highest antibacterial potency against the pathogenic isolates recording minimum inhibitory concentration (MIC) of 1 mg/disc against MRSA strain & 0.5 mg/disc against both of E.

   • According to Mathkoor MM (2024)

     Excerpt aureus), Pseudomonas aeruginosa (P aeruginosa), & Escherichia coli (E. It evaluated their ability to inhibit pathogenic & antibiotic-resistant bacteria, including Staphylococcus aureus (S.

   • According to Abd El Azim M (2014)

     Excerpt Antimicrobial activity of the methanol extract of licorice roots was studied against three bacterial and four fungal strains at concentration 0.1 ml and 0.3 ml (10 mg/1 ml)). Eleven phenolic compounds were identified from the methanolic extract of Cloves flowers buds (Syzygium aromaticum L.) by chromatographic methods.

2. 2

   Cancer: adjuvant treatment for colorectal, breast, prostate, oesophageal and uterine cancer

   Plant part used: Fruit (flower bud).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Abd El Azim M (2014)

     Excerpt Eleven phenolic compounds were identified from the methanolic extract of Cloves flowers buds (Syzygium aromaticum L.) by chromatographic methods. The results showed that the IC50 were (31 μg/mL for anti-colon cancer, 29.7 μg/ml for anti-breast cancer and 18.7 μg /ml for anti-hepatic cancer).

   • According to Yassin MT (2020)

     Excerpt aromaticum extracts against HCT human colon carcinoma was appraised using MTT assay.

   • According to Banerjee S (2006)

     Excerpt Clove, the Sun-dried un-opened flower Bud from the plant Syzygium aromaticum L. Incidence of hyperplasia, dysplasia and carcinoma in situ evident in the carcinogen control group on the 8th, 17th and 26th weeks, respectively, were effectively reduced after treatment with clove infusion.

   • According to Dwivedi V (1989)

     Excerpt Water, ethanol & extracts were screened for anti-proliferative activity against HeLa (cervical cancer), MCF-7 (ER + ve) & MDA-MB-231 (ER – ve) breast cancer, DU-145 prostate cancer & TE-13 esophageal cancer cell lines, along with normal human peripheral blood lymphocytes. The objective of the present study is to compare the in vitro anticancer activities of three different extracts of Clove (Syzygium aromaticum L), a commonly used spice & food flavouring agent, against different kinds of cancer cell lines of various anatomical derivations.

   • According to DA COSTA JS (2020)

     Excerpt The oils presented many biological activities, especially antimicrobial (antifungal & antibacterial), anticholinesterase, anticancer (breast, gastric, melanoma, prostate), antiprotozoal (Leishmania spp.), antioxidant, acaricidal, antinociceptive & anti-inflammatory. These studies can contribute to the rational & economic exploration of Eugenia & Syzygium species once they have been identified as potent natural & alternative sources to the production of new herbal medicines,.

3. 3

   Fungal diseases of tomatoes and peas (Pisum sativum): Rhizoctonia solani,

   Plant part used: Pest control and veterinary products.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Abd El Azim M (2014)

     Excerpt Antimicrobial activity of the methanol extract of licorice roots was studied against three bacterial and four fungal strains at concentration 0.1 ml and 0.3 ml (10 mg/1 ml)). Eleven phenolic compounds were identified from the methanolic extract of Cloves flowers buds (Syzygium aromaticum L.) by chromatographic methods.

   • According to Emmanuel (2015)

     Excerpt Emmanuel et al, Phytochemical Screening & Antimicrobial Sensitivity of Clove Flower (Syzygium aromaticum, L.

   • According to Sathishkumar M (2017)

     Excerpt Sathishkumar M et al, green synthesis, Characterization & Antimicrobial activity of ZnS using Syzygium aromaticum extracts, Inter J of Chem Tech Res, 10(9) :443-9 (2017),.

   • According to Ramadan MF (2013)

     Excerpt Ramadan MF et al, Lipid profile, antiradical power & antimicrobial properties of Syzygium aromaticum oil, Grasas y Aceites, 64: 5 (2013).

   • According to Fu Y (2009)

     Excerpt P acnes is a gram-positive anaerobic microorganism recognized as the major skin bacterium causing acne.1 SA Its antimicrobial property has been reported, 2 but to our knowledge its antibacterial activity toward P acnes of the essential oil is the extract of Syzygium aromaticum. Clove essential oil exerted significant antibacterial activity toward P acnes.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.