Ziziphus mauritiana (Jijib) : medicinal properties in alcoholic extraction

Ziziphus mauritiana (Jijib, Jujube tree, Jujubier) — family Rhamnacées.

Scientific synonyms : Rhamnus jujuba L., Rhamnus mauritiana Willemet, Ziziphus jujuba (L.) Gaertn., Ziziphus jujuba (L.) Lam., Z. Poiretti-Don, Z. tomentosa-Poir, Z. rotundata DC., Z. sphaerocarpa auct Non Tul.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 24 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 91 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to BHATHIA A (2008)

     Excerpt In the present study, the hypoglycemic effect of seed extract of Ziziphus mauritiana in alloxan-induced diabetic mice was assessed. Seed extract was administered orally at doses of 100, 400, & 800 mg/kg body weight (BW) & also in combination with Glyburide (800 mg/kg seed extract & 10 mg/kg glyburide) to different groups of mice (normal & alloxan-treated diabetic mice).

   • According to RAHBARDAR MG (2024)

     Excerpt This review evaluates the therapeutic potential of Ziziphus jujuba & its main components in managing complications of metabolic syndrome, including diabetes, dyslipidemia, obesity, & hypertension. They also improve insulin sensitivity by modulating AMP-activated protein kinase (AMPK) activity & regulating insulin signaling proteins & glucose transporters.

   • According to Li YM (2023)

     Excerpt SZJ-2 can improve the hyperglycemic by increasing the glucose consumption, improving the superoxide dismutase (SOD), hexokinase (HK), pyruvate kinase (PK) activities, & decrease the MDA content of insulin resistant HepG2 cells. Conclusion: These results indicating that the SZJ-1 & SZJ-2 might improve the insulin resistant symptoms by improving the energy metabolic level &increasing the glycogen synthase activity of HepG2 cells.

   • According to Jarald EE (2009)

     Excerpt Jarald EE et al, Antidiabetic activity of extracts and fraction of Ziziphus mauritiana.

2. 2

   Hepatitis, cirrhosis, fatty liver,

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Huang S (2021)

     Excerpt Jujube polysaccharides (JP) is one of the active food sourced glycans in dietary fruit of Ziziphus jujuba, which has been considered for the treatment of blood deficiency.

   • According to Dahiru D (2005)

     Excerpt mauritiana leaf extract protected rats against carbon tetrachloride liver injury by significantly lowering aspartate aminotransaminase (AST), alanin & (ALT), alkaline phosphatase (ALP), total Bilirubin (TB), & lipid peroxide levels compared to control. Protective effect of ethanol extract of Z mauritiana leaf was studied on carbon tetrachloride induced liver damage.

   • According to Dahiru D (2008)

     Excerpt Dahiru D et al, Evaluation of the antioxidant effects of Ziziphus mauritiana Lam leaf extracts against chronic ethanol-induced hepatotoxicity in rat liver.

   • According to Dahiru D (2009)

     Excerpt Dahiru D et al, Effect of aqueous extract of Ziziphus mauritiana leaf on cholesterol & triglycerides level in serum & liver of rats administered alcohol.

   • According to SAID A (2010)

     Excerpt The volatile constituents from fresh aerial parts (leaves & flowers) of Zizyphus jujuba & fruits of Zizyphus spina-Christi (Rhamnaceae) were analyzed by GC & GC-MS. spina-Christi was comprised mainly of fatty acids & their esters, of which dodecanoic acid (22.4 %) was the main component.

3. 3

   Cancer: adjuvant treatment for breast cancer

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hosmer R (2015)

     Excerpt jujube fruit on the proliferation of breast cancer cells by MTT assay and the antioxidant by FRAP, haematological & biochemical alterations caused by NMU(Methyl-Nitroso-Urea)-induced mammary carcinogenesis in rats. Conclusions: These findings indicate that the ZJ ameliorates the adverse effects of NMU carcinogenesis & could be useful for treating mammary tumours in humans.

   • According to Plastina P (2012)

     Excerpt Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative & apoptotic effects in human breast cancer cells.

   • According to Pauloi L (2024)

     Excerpt ziziphus mauritiana Lam., a tropical fruit-bearing tree commonly known as Bidara tree in Malaysia, has a long & rich history of use in traditional medicine. Notably, many of these identified compounds have demonstrated promising antibacterial, antioxidant, anti-inflammatory, & anticancer properties in previous scientific studies.

   • According to KHANAM A (2025)

     Excerpt The present study aimed to assess the antioxidant & anti-inflammatory activities of polyphenol-rich extracts of seedless variety of Ziziphus mauritiana (SZM). The anti-inflammatory activity was evaluated on carrageenan-induced rat model & suppression of inflammatory biomarkers (Interleukin-6, Tumor necrosis factor-α & CRP) were studied.

   • According to Choi S-H (2012)

     Excerpt Changes in free amino acid, protein, & flavonoid content in jujube (Ziziphus jujube) fruit during eight stages of growth & antioxidative & cancer cell inhibitory effects by extracts.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.