Hura crepitans (Sabliyé) : vertus médicinales en extraction alcoolique

Hura crepitans (Sabliyé, Sablier, Hourglass) — famille Euphorbiacées.

Synonymes scientifiques : Hura brasiliensis-Willd, H senegalensis-B, H strepens-Wiild.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 9 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 40 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Semence.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon HALIMAT LY (2024)

     Extrait This study evaluated the antidiabetic potential of methanolic extract of Hura crepitans using in vitro, in vivo, & in silico approach. Likewise, the extract increased serum &pancreatic insulin levels, & signicantly ameliorated neuronal oxidative stress & inammation by reducing the expression levels of cholinesterase, NF-κB, & COX-2 in the brain of hyperglycemic rats.

   • Selon Igwenyi T (2017)

     Extrait The Hura crepitans (Sandbox tree) seed extract (HSE) is used traditionally in the treatment of certain diseases & conditions like diabetes mellitus & its complications in Nigeria; however, there are no systematic investigations that have confirmed its antidiabetic potential. The study investigated the antidiabetic & hepatoprotective effects of ethanol extract of HC seed in alloxan-induced diabetic rats so as to ascertain its therapeutic value, safety & possible toxicity.

   • Selon CHELOTTI ME (2025)

     Extrait This study aims to critically review the scientific literature on the medicinal use of Hura crepitans L. Plant parts—particularly latex, seeds, & bark—contain bioactive metabolites such as flavonoids, tannins, daphnane-type diterpenes, lectins, & ribosome-inactivating proteins, associated with antioxidant, anti-inflammatory, antitumor, antimicrobial, antidiabetic, & antiparasitic activities.

2. 2

   Hépatite, cirrhose, stéatose hépatique

   Partie usitée : Semence.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Extrait Os (2020) — extrait : This paper reviews the potential of the Hura crepitans plant in protecting the liver against drug-induced toxicity. However much more biochemical studies need to be done to establish the hepatoprotective potentials of the various parts & various phytochemicals of Hura crepitans with the need for more preclinical & clinical studies.

   • Selon Owojuyigbe OS (2021)

     Extrait Hura crepitans is commonly used to treat liver diseases in Nigeria & Ghana. Materials & methods The protective activities of ethanolic extract of HC stem bark was evaluated in CCl4-induced subacute liver damage in rats (1:1 v/v in olive oil, intraperitoneally (i.p.), twice weekly for 8 weeks).

   • Selon Ezeh G (2020)

     Extrait This study investigated thetoxicity profile of methanol extract of Hura crepitans leaf on albino rats. This study suggests that methanol extract of HC has hepatoprotective activity, promotes weight gain & could precipitate anemia when taken for a long period.

   • Selon Owojuyigbe OS (2020)

     Extrait crepitans stem bark in CCl 4-induced liver injury in Sprague-Dawley rats. EE, AE, & silymarin displayed significant hepatoprotective activities by ameliorating the activities of transaminase (ALT & AST) & alkaline phosphatase (ALP) & decreased the levels of total bilirubin (TBIL) following increases induced by CCl 4.

   • Selon OLATUNYA A (2024)

     Extrait The bioactive lipids (fat-soluble vitamins, phytosterol, & fatty acids), phospholipids, & phytochemicals present in Hura crepitans seed oil were investigated using standard analytical procedures.

3. 3

   État inflammatoire : arthrose, arthrite, rhumatisme, oedème

   Partie usitée : Écorce de tige.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Extrait Os (2020) — extrait : However much more biochemical studies need to be done to establish the hepatoprotective potentials of the various parts & various phytochemicals of Hura crepitans with the need for more preclinical & clinical studies. (Euphorbiaceae) or sandbox tree has been beneficial in many ethnomedicinal applications as a purgative, emetic, hepatoprotective, anti-inflammatory, antimicrobial & the treatment of leprosy.

   • Selon Owojuyigbe OS (2021)

     Extrait Hura crepitans is commonly used to treat liver diseases in Nigeria & Ghana. The plant also mitigated liver injury as evidenced in the significantly reduced levels of AST, ALT & ALP, while it inhibited the inflammatory process via the inhibition of NF-κB, & consequently down-regulateed the pro-inflammatory cytokines COX-2, IL-17 & IL-23, respectively.

   • Selon KUO YC (2025)

     Extrait Despite the recognized therapeutic potential of Hura crepitans, its mechanistic antioxidant & anti-inflammatory actions remain underexplored. Anti-inflammatory activities, including protein denaturation, proteinase inhibition, & membrane stabilization, demonstrated IC50 values between 77.29-171.30 µg/mL.

   • Selon Igwe KK (2017)

     Extrait Igwe KK et al, Screening for secondary metabolites in Hura crepitans bark ethanol extract using GC-MS analysis: a preliminary study approach, Jl of Sci & Technol Adv., 2017; 2 (1): 8-15. Conclusions: The bioactivity studies showed that HC bark could be a urinary acidifier, inhibitor of uric acid production, antibacterial, prevents inflammation & vasodilatation.

   • Selon CHELOTTI ME (2025)

     Extrait Plant parts—particularly latex, seeds, & bark—contain bioactive metabolites such as flavonoids, tannins, daphnane-type diterpenes, lectins, & ribosome-inactivating proteins, associated with antioxidant, anti-inflammatory, antitumor, antimicrobial, antidiabetic, & antiparasitic activities. This study aims to critically review the scientific literature on the medicinal use of Hura crepitans L.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.