Melissa officinalis (Lamélis) : vertus médicinales en extraction alcoolique

Melissa officinalis (Lamélis, Mélisse) — famille Lamiacée.

Synonymes scientifiques : Faucibarba officinalis-(L)-D., Melissa bicornis-K., Mutelia officinalis-(L)-Gren. Ex M, Thymus melissa-(L)-E.H.L. Krause..

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 16 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 51 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome colorectal, mammaire, ovarien et prostatique & du glioblastome

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Jahanban-Esfahlan A (2015)

     Extrait MTT assays were used to evaluate cytotoxicity of different doses of MOE (0, 5, 20, 100, 250, 500, 1000 µg/ml) towards A549 (lung non-small cell cancer cells), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer cells), & PC-3 (prostate adenocarcinoma) cells. Moreover, the antiproliferative effect of MO seems to be tumour type specific, as hormone dependant cancers were more sensitive to antitumoral effects of MOE.

   • Selon Kuo TT (2020)

     Extrait Cumulating evidence indicates noticeable chemopreventive effects of phytochemicals on CRC, suggesting that drinking herbal tea potentially reduces the risk of distal colon cancer via its antiproliferative and anti-angiogenic activities. Among them, the hot water extract of Melissa officinalis (MO) exhibited the highest anticancer activity on CRC cells.

   • Selon LIN JT (2012)

     Extrait Antioxidant, anti-proliferative & cyclooxygenase-2 (COX-2) inhibitory activities of ethanolic extracts from freeze (EF) & hot air (EH) dried lemon balm (Melissa officinalis L.) leaves were evaluated. EF also presented higher antioxidant (β-carotene bleaching inhibition, scavenging 2, 2-diphenyl-1-picrylhydrazyl radicals, reducing power & Trolox equivalent antioxidant capacity), anti-proliferative (proliferative inhibition for Hep G2, KB & TSGH 9201 human cancer cells) & COX-2 (induced by 12-O-teradecanoylphorbol-13-acetate in KB cells) suppressing activities than EH.

   • Selon WEIDNER C (2015)

     Extrait In this study, we describe the antiproliferative & proapoptotic effects of ethanolic lemon balm (Melissa officinalis) leaves extract in human colon carcinoma cells. Conclusions: Lemon balm (M officinalis) extract inhibits the proliferation of colon carcinoma cells & induces apoptosis through formation of ROS.

   • Selon Mouhid L (2018)

     Extrait METHODS: In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium & Calendula officinalis) & Lamiaceae (Melissa officinalis & Origanum majorana) plant extracts obtained by different green technologies (Supercritical CO2 Extraction -SFE- & Ultrasonic Assisted Extraction -UAE-) to identify efficient plant extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches. CONCLUSION: These results show how Yarrow & Marigold SFE-derived extracts can inhibit pancreatic cancer cell growth, & could be proposed for a comprehensive study to determine the molecular mechanisms involved in their bioactivity with the final aim to propose them as potential adjuvants in pancreatic cancer therapy.

2. 2

   Traitement adjuvant du carcinome pancréatique (association synergique avec 5-Fluoro-Uracile)

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Mouhid L (2018)

     Extrait METHODS: In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium & Calendula officinalis) & Lamiaceae (Melissa officinalis & Origanum majorana) plant extracts obtained by different green technologies (Supercritical CO2 Extraction -SFE- & Ultrasonic Assisted Extraction -UAE-) to identify efficient plant extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches. CONCLUSION: These results show how Yarrow & Marigold SFE-derived extracts can inhibit pancreatic cancer cell growth, & could be proposed for a comprehensive study to determine the molecular mechanisms involved in their bioactivity with the final aim to propose them as potential adjuvants in pancreatic cancer therapy.

   • Selon WEIDNER C (2015)

     Extrait In this study, we describe the antiproliferative & proapoptotic effects of ethanolic lemon balm (Melissa officinalis) leaves extract in human colon carcinoma cells. Conclusions: Lemon balm (M officinalis) extract inhibits the proliferation of colon carcinoma cells & induces apoptosis through formation of ROS.

   • Selon Jahanban-Esfahlan A (2015)

     Extrait Moreover, the antiproliferative effect of MO seems to be tumour type specific, as hormone dependant cancers were more sensitive to antitumoral effects of MOE. Here, we investigated the selective anticancer effects of an MO extract (MOE) in different human cancer cells.

   • Selon LIN JT (2012)

     Extrait Antioxidant, anti-proliferative & cyclooxygenase-2 (COX-2) inhibitory activities of ethanolic extracts from freeze (EF) & hot air (EH) dried lemon balm (Melissa officinalis L.) leaves were evaluated. EF also presented higher antioxidant (β-carotene bleaching inhibition, scavenging 2, 2-diphenyl-1-picrylhydrazyl radicals, reducing power & Trolox equivalent antioxidant capacity), anti-proliferative (proliferative inhibition for Hep G2, KB & TSGH 9201 human cancer cells) & COX-2 (induced by 12-O-teradecanoylphorbol-13-acetate in KB cells) suppressing activities than EH.

   • Selon Kuo TT (2020)

     Extrait Among them, the hot water extract of Melissa officinalis (MO) exhibited the highest anticancer activity on CRC cells. Cumulating evidence indicates noticeable chemopreventive effects of phytochemicals on CRC, suggesting that drinking herbal tea potentially reduces the risk of distal colon cancer via its antiproliferative and anti-angiogenic activities.

3. 3

   Herpès simplex

   Partie usitée : Feuille. Profil pharmacologique documenté : Acyclovir-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon WÖLBING RH (1994)

     Extrait An overt multicentric study involving 115 patients and another subsequent placebo-controlled double-blind study involving 116 patients contributed significantly to the corroborative evidence of the antiviral activity in vitro of a specially prepared dried extract from Melissa leaves against herpes simplex infections. The studies provided the proof that the ingredient gave protection against herpes simplex infections.

   • Selon ARAUJO SG (2014)

     Extrait In the present work, we identified the volatile compounds of ethanol extracts of Melissa officinalis, Mentha sp. Also was evaluated antimicrobial activity of ethanol extracts against 6 bacteria of clinical interest, & was tested the interaction of these extracts with a commercial antibiotic Streptomycin.

   • Selon ALLAHVERDIYEV A (2004)

     Extrait officinalis on Herpes simplex virus type 2 (HSV-2) replication in HEp-2 cells. officinalis volatile oil was found to be non-toxic to HEp-2 cells up to a concentration of 100 micro/ml.

   • Selon MAZZANTI (2008)

     Extrait In this work the antiviral activity of a hydroalcoholic extract of lemon balm leaves against the Herpès simplex virus type 2 (HSV-2) were assessed by the cytopathic effect inhibition assay on Vero cells (ATCC CCL-81), in comparison with Acyclovir. (Lamiaceae) (lemon balm) is used in folk medicine for nervous complaints, lower abdominal disorders &, more recently, for treating Herpès simplex lesions.

   • Selon Behzadi A (2023)

     Extrait Today, research has shown that this plant can also fight viruses including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Herpes Simplex Virus (HSV), & Human Immunodeficiency Virus (HIV) through various mechanisms such as inhibiting HSV-1 from binding to host cell, inhibiting HSV-1 replication during the post-adsorption or inhibiting main protease & spike protein of SARS-CoV-2, furthermore, be effective in treating related diseases. Melissa officinalis has been widely used for reducing stress & anxiety, increasing appetite & sleep, reducing pain, healing wounds, & treating poisonous insect bites & bee stings for a long time.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.