Myristica fragrans (Miskad) : vertus médicinales en extraction alcoolique

Myristica fragrans (Miskad, Muscade) — famille Myristicacées.

Synonymes scientifiques : Myristica. amboinensis-Gand, M. americana-Roth, M. Aromatica-Lam, M. officinalis-L.

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 14 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 62 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Hépatite, cirrhose, stéatose hépatique, Diabete mellitus de type II

   Partie usitée : Noix. Profil pharmacologique documenté : Acarbose-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon KAUSA MA (2025)

     Extrait The present study investigates the therapeutic effects of an ethanolic polyherbal extract from Citrullus colocynthis (Bitter Apple), Curcuma longa (Turmeric), & Myristica fragrans (Nutmeg) using advanced in silico & analytical methods. Diabetic neuropathy is one of the severe complications of diabetes, which affects the quality of life in a patient & increases the risk of amputations & chronic wounds.

   • Selon Perumalsamy R (2022)

     Extrait This study aimed to synthesize silver nanoparticles from a hydroethanolic extract of Myristica fragrans seeds (MFHE) & evaluate their anti-diabetic properties. Myristica fragrans, also known as nutmeg, is a spice that cures various diseases.

   • Selon LUO J (2026)

     Extrait Myristica fragrans Houtt. fragrans, & comprehensively summarize recent advances in its botanical characterization, traditional uses, phytochemistry, pharmacological properties, & toxicology, thereby providing a solid foundation for the in-depth study & rational utilization of this resource.

   • Selon Morita T (2003)

     Extrait To evaluate the hepatoprotective activity of spices, 21 different spices were fed to rats with liver damage caused by lipopolysaccharide (LPS) plus d-galactosamine (D-GalN). These findings suggest that the hepatoprotective activity of myristicin might be, at least in part, due to the inhibition of TNF-alpha release from macrophages.

   • Selon Bamidele O (2016)

     Extrait The effects of Myristica fragrans on cadmium-induced hepatotoxicity & nephrotoxicity was studied in female Wistar rats. M fragrans seed has protective & therapeutic potentials against cadmium-induced hepatotoxicity & nephrotoxicity in female albino rats.

2. 2

   Cancer : traitement adjuvant du carcinome : nerveux central (astrocytome, gliome), colorectal, prostatique & utérin

   Partie usitée : Noix.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Piaru S.P (2012)

     Extrait In this study the chemical composition, antioxidant activities & cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) & Morinda citrifolia were determined. The MTT assay of nutmeg oil on human colorectal carcinoma (HCT‐116) & human breast carcinoma (MCF‐7) cell lines showed IC50 values of 78.61 & 66.45 µg mL−1, respectively.

   • Selon Prakash E (2013)

     Extrait The objective of the present study was to evaluate the in-vitro anticancer effects of ethanolic extract of seed of Myristica fragrans against seven human cancer cell lines ascribed to central nervous system (SF295=astrocytoma, glioma), Colon cell (Colon502713, Colo205), Liver (Hep-2), Lung (A-549), Ovary OVCAR-5 & Prostate (PC-5). Further investigation for active compound present in MF is required for cancer management & for the development of new anti-cancer drugs.

   • Selon Suthisampat N (2020)

     Extrait The aril (mace) of Myristica fragrans, known as Dok-Chan, is a spice that has long been used for treating stomach discomfort, peptic ulcer, & nausea. Anti-inflammatory activity was determined by the LPS-induced nitric oxide (NO) inhibition in a RAW264.7 cell line, & cytotoxicity was determined against gastric cancer cell lines (Kato III) using the Sulphorhodamine B (SRB) assay.

   • Selon Rizwana H (2021)

     Extrait Mace, the arils of Myristica fragrans, are a rich source of several bioactive compounds, including polyphenols & aromatic compounds. Additionally, the synthesized mace-AgNPs displayed an excellent cytotoxic effect against the human cervical cancer cell line.

   • Selon ZAIDI F (2008)

     Extrait The 70% aqueous-ethanol extracts of Curcuma armada, Mallotus philippinensis, Myristica fragrans & Psoralea corylifolia demonstrated strong anti-Helicobacter pylori activity with MBC value ranged from 15.6 to 62.5 microg/ml. Helicobacter pylori infection plays a crucial role in the pathogenesis of Peptic ulcer, & gastric cancer.

3. 3

   Infection bacterienne : Bacillus subtilis, Staphylococcus aureus

   Partie usitée : Noix.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon IBRAHIM KM (2013)

     Extrait fragrans seed extract tested against four bacteria species; two Gram-positive bacteria (Bacillus subtilis, & Staphylococcus aureus) & two Gram-negative bacteria (Escherichia coli & Pseudomonas aeruginosa). Results showed that ethanol & acetone extracts exhibited antibacterial activity against gram positive bacterial species only, the diameter of inhibition zone reached 25mm against Staph aureus by crush extract.

   • Selon OO T (2021)

     Extrait Bacterial resistance involves the expression of efflux pump systems (chromosomal norA & mepA) in Methicillin-Resistant Staphylococcus aureus (MRSA). Myristica fragrans Houtt.

   • Selon Balakrishnan S (2020)

     Extrait Here, we report antibiofilm activity & quorum sensing inhibition of aqueous seeds extract of Myristica fragrans (nutmeg) & biosynthesized silver nanoparticles (AgNPs) against multidrug resistant (MDR) Salmonella enterica serovar Typhi (S. Globally, Salmonella infection poses a major public health problem.

   • Selon ZAIDI F (2008)

     Extrait The 70% aqueous-ethanol extracts of Curcuma armada, Mallotus philippinensis, Myristica fragrans & Psoralea corylifolia demonstrated strong anti-Helicobacter pylori activity with MBC value ranged from 15.6 to 62.5 microg/ml. Helicobacter pylori infection plays a crucial role in the pathogenesis of Peptic ulcer, & gastric cancer.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.