Symphytum officinale (Konsoud) : vertus médicinales en extraction alcoolique

Symphytum officinale (Konsoud, Consoude, Consoude officinale, Comfrey, Common comfrey) — famille Boraginacées.

Synonymes scientifiques : Symphytum bohemicum F.W. Schmidt, S elatum Tausch, S majus Bubani, S microcalyx Opiz, S molle Janka, S officinale subsp bohemicum (F.W. Schmidt) Celak. S officinale var, ochroleucum DC., S officinale var, rectiflorum Tous. & H, S patens Sibth., S tanaicense Steven, S peregrinum Ledeb..

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 5 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 62 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome hépatique

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Pereira Lavieri Gomes (2010)

     Extrait Symphytum officinale (L.) (Boraginaceae) is a very popular plant used for therapeutic purposes. Since the 1980s, its effects have been studied in long-term carcinogenesis studies, in which SO extract is administered at high doses during several months & the neoplastic hepatic lesions are evaluated.

   • Selon Mei N (2006)

     Extrait Among these genes, there were 1,617 genes associated by Ingenuity Pathway Analysis with particular functions, & the differentially expressed genes in comfrey-fed rat livers were involved in metabolism, injury of endothelial cells, & liver injury & abnormalities, including liver fibrosis & cancer development. Our previous study suggested that comfrey induces liver tumors by a genotoxic mechanism and that the pyrrolizidine alkaloids in the plant are responsible for mutation induction & tumor initiation in rat liver.

   • Selon Hirono I (s.d.)

     Extrait The carcinogenicity of Symphytum officinale L., Russian comfrey, used as a green vegetable or tonic, was studied in inbred ACI rats. Hepatocellular adenomas were induced in all experimental groups that received the diets containing comfrey roots & leaves.

   • Selon Nastic N (2020)

     Extrait officinale root was investigated for all applied techniques.

   • Selon Ezejindu DN (2015)

     Extrait The aim of this study is to investigate the effect of aqueous extract of Symphytum officinale leaf (common comfrey) on the liver of adult Wistar rats. The results of this study revealed that consumption of SO in low dose or small amount had no effect on the histological appearance of the liver but when consumed in high dose or excessive induced mild distortion of histological liver appearance which includes mild central vein hypertrophy, increased cellularity & periportal fibrosis of liver cells.

2. 2

   État inflammatoire : traitement adjuvant : arthrose, arthrite, rhumatisme, œdème

   Partie usitée : Racine. Profil pharmacologique documenté : Diclofenac-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon VOSTINARU O (2017)

     Extrait The present work evaluated the anti-inflammatory & antinociceptive activity of a Symphytum officinale root extract standardized in rosmarinic acid. The anti-inflammatory effect of the hydro-Glycero- alcoholic extract administered orally was assessed by the carrageenan-induced rat paw oedema method while the antinociceptive effect was determined by the acetic acid induced writhing test in mice & by Randall Selitto test in rats.

   • Selon Kumar DTY (2020)

     Extrait The present study was carried out to assess the possible anti-inflammatory effect of methanolic extract of roots of S officinale MERSO) using egg white-induced edema in rats (acute model of inflammation). The anti-inflammatory effect of MERSO was evaluated in acute inflammation model using 30 Wistar albino rats & divided into five groups including normal saline 10 ml/kg orally, diclofenac 5 mg/kg IP & MERSO 250,500 & 700mg/kg b.wt orally.

   • Selon Seigner J (2019)

     Extrait Symphytum officinale, commonly known as comfrey, constitutes a traditional medicinal plant with a long-standing therapeutic history, & preparations thereof have been widely used for the treatment of painful muscle & joint complaints, wound and bone healing, & inflammation. Today, its topical use is based on its analgesic & anti-inflammatory effects, which have been substantiated by modern clinical trials.

   • Selon Trifan A (2020)

     Extrait officinale root may contribute to the overall anti-inflammatory activity for which comfrey preparations are used in traditional medicine,. officinale & evaluate their antioxidant potential, alongside their effect on the cytokine production of ex vivo stimulated neutrophils, thus providing scientific support for the traditional use of comfrey root.

   • Selon Zakaria MM (2021)

     Extrait Comfrey (Symphytum officinale) is a medicinal plant with anti-inflammatory, analgesic, & proliferative properties.

3. 3

   Douleur, hyperalgie

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon VOSTINARU O (2017)

     Extrait officinale extract (500 mg/kg, orally) demonstrated a strong peripheral antinociceptive effect in the first two hours after administration increasing the pain threshold by 58%. The present work evaluated the anti-inflammatory & antinociceptive activity of a Symphytum officinale root extract standardized in rosmarinic acid.

   • Selon Mazzochi A (2012)

     Extrait Conclusions: Adding Symphytum 5CH to conventional analgesia may reduce pain & swelling after minor dental implant surgery. To assess the effect of Symphytum 5CH on the postoperative pain & swelling after placement of a titanium dental implant.

   • Selon Smith DB (2011)

     Extrait The subjects were randomly assigned to 1 of 3 treatment groups: 10% or 20% comfrey root extract (Symphytum officinale) or a placebo cream. Results: Repeated-measures analyses of variance yielded significant differences in all of the Western Ontario & Macmaster Universities Osteoarthritis Index categories (pain P < .01, stiffness P < .01, daily function P < .01), confirming that the 10% & 20% comfrey-based creams were superior to the reference cream.

   • Selon Masoudi M (2017)

     Extrait Result: the result of this study indicated that Symphytum officinale possess anti-cancer & osteoarthritic pain activity. Conclusion: based on the result, S officinale was shown to be effective in carcinoma treatment as well as being effective in relieving pain & stiffness and in improving physical functioning & were superior to placebo in those with primary osteoarthritis of the knee without serious adverse effects,.

   • Selon Frost R (2013)

     Extrait External preparations of the herb comfrey (most commonly Symphytum officinale L.) are widely available for over-the-counter, practitioner & healthcare professional usage. Results: Of 1348 identified records, 64 full texts were screened for inclusion & 26 were included in the review – 13 RCTs, 5 non-randomised controlled trials and 8 observational studies evaluating treatments for ankle distortion, back pain, abrasion wounds, venous leg ulcers & osteoarthritis.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.