Uncaria tomentosa (Grif-chat) : vertus médicinales en extraction alcoolique

Uncaria tomentosa (Grif-chat, Pérou, Griffe-à-chat du Pérou, Cat's claw, Peru, Peruvian cat's claw) — famille Rubiacées.

Synonymes scientifiques : Nauclea tomentosa Willd. ex Schult..

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 23 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 170 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Syndrome métabolique : diabète mellitus de type III

   Partie usitée : Écorce de tige. Profil pharmacologique documenté : Glibenclamide-like, Metformine-like, Vildagliptine-like. Association synergique mentionnée : Stévia Rebaudiana.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Dooley TP (2021)

     Extrait GlucoMedix® is an all-natural phytotherapy consisting of a hydro-alcoholic extract of Stevia rebaudiana (Bertoni) Bertoni & pentacyclic chemotype Uncaria tomentosa (Willd. At baseline four of the six patients were administering one or more prescription treatments for hyperglycemia, e.g., Glibenclamide, Metformin, Vildagliptin, or Insulin.

   • Selon Xu QQ (2021)

     Extrait Uncaria tomentosa, which has similar chemical constituents with Uncaria rhynchophylla, has been reported to alleviate cognitive impairments in Alzheimer's disease (AD) animal models. Streptozotocin (STZ) was intracerebroventricularly (ICV) injected into adult male Sprague–Dawley (SD) rats to establish AD model.

   • Selon Domingues A (2011)

     Extrait Uncaria tomentosa (Willd.) DC (Rubiaceae) is a species native to the Amazon rainforest & surrounding tropical areas that is endowed with immunomodulatory properties & widely used around the world. In this study we investigated the immunomodulatory potential of UT aqueous-ethanol extract on the progression of immune-mediated diabetes.

   • Selon Araujo LCC (2017)

     Extrait Results herein reported prompted to the conclusion that the improvement in insulin sensitivity induced by the Uncaria tomentosa crude extract is associated with a reduction in inflammatory index in the liver of obese mice. We investigated the effect of the herbal extract Uncaria tomentosa (Ut) (50 mg/kg, crude extract, for 5 consecutive days) in two mice models of obesity: high fat diet (DIO) fed mice and the genetic ob/ob mice.

   • Selon Araujo LCC (2018)

     Extrait We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) & genetically obese (ob/ob) mice. Both obese mouse models were insulin resistant & exhibited an abundance of lipid droplets in the hepatocytes & inflammatory cell infiltration in the liver, while only the HFD group had collagen deposition in the perivascular space of the liver.

2. 2

   Cancer : traitement adjuvant de l’adénocarcinome vésical

   Partie usitée : Écorce de tige.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Dietrich F (2014)

     Extrait With this goal in mind, Uncaria tomentosa is noteworthy because the bark & root of this species are widely used in traditional medicine & in adjuvant therapy for the treatment of numerous diseases. The objective of this study was to investigate the antitumor effect of one purified bioactive fraction of U.T bark on cell proliferation in two human bladder cancer cell lines, T24 & RT4.

   • Selon Kaiser S (2013)

     Extrait The antitumor activity of Uncaria tomentosa, a native vine from the Amazonian rainforest, has been ascribed to pentacyclic oxindole alkaloids occurring in its bark. Thus, the alkaloid profile of all fractions & their cytotoxic activities against T24 & RT4 human bladder cancer cell lines are determined to a large extent by the incubation conditions.

   • Selon Muhammad I (2001)

     Extrait The C-8-(S) isomer of deoxyloganic acid (7-deoxyloganic acid), together with beta-sitosteryl glucoside, five known stereoisomeric pentacyclic oxindole alkaloids & the tetracyclic oxindole isorhyncophylline, were isolated from the inner bark of Uncaria tomentosa. Uncarine D showed weak cytotoxic activity against SK-MEL, KB, BT-549 & SK-OV-3 cell lines with IC (50) values between 30 & 40 microg/ml, while uncarine C exhibited weak cytotoxicity only against ovarian carcinoma (IC (50) at 37 microg/m.

   • Selon Shen J (2018)

     Extrait Methods: Solvent extracts were prepared from UT inner bark & their antiproliferative activities against Caco2 & HeLa cancer cells were determined by an MTS based cell proliferation assay. Conclusions: The antiproliferative activity of the UT inner bark extracts against HeLa & Caco2 cancer cell lines indicates their potential in the treatment & prevention of some cance&.

   • Selon Ciani F (2021)

     Extrait Uncaria tomentosa, called “uña de gato,” belonging to the Rubiaceae family, is a thorny liana that grows wild in the upper Amazon region of Peru & neighboring countries. In particular, alkaloids, the major active components of Uncaria species, have been extensively studied for their potential use as anticancer agents.

3. 3

   État inflammatoire: arthrose, rhumatisme, oedème

   Partie usitée : Écorce de tige.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Saga-Sowjanya J (2023)

     Extrait Traditionally Uncaria tomentosa plant is used in the treatment of rheumatoid arthritis as Non-steroidal Anti-inflammatory agent along with analgesic properties. No scientific data was reported on Uncaria plant formulation as FDOF's for treating osteoarthritis.

   • Selon Aguilar JL (2002)

     Extrait We assessed in vivo the anti-inflammatory activity of two Cat's claw bark extracts, by comparing a spray-dried hydroalcoholic extract against an aqueous freeze-dried extract, to determine which extract was more effective. Results showed that the anti-inflammatory activity was significantly higher using the hydroalcoholic compared with the aqueous extract (P<0.05).

   • Selon Marin-Arado G (2024)

     Extrait Conclusion: Many extracts of stem bark, roots, & leaves of UT, mostly aqueous & hydroethanolic, exhibited anti-inflammatory and/or immunomodulatory activities & low toxicity. Uncaria tomentosa (Willd.

   • Selon Ciani F (2021)

     Extrait Uncaria tomentosa, called “uña de gato,” belonging to the Rubiaceae family, is a thorny liana that grows wild in the upper Amazon region of Peru & neighboring countries. The indigenous people of Amazonian rain forest have used its root/bark over the centuries for the treatment of several diseases, & this plant is believed to have antioxidant, anti-inflammatory, & antitumoral properties.

   • Selon Riva L (2001)

     Extrait Uncaria tomentosa, also known as "Uña de gato", is a Rubiaceae species widely used in South-American folk medicine for the treatment of cancer, arthritis, gastritis & epidemic diseases. Extracts of the plant have been shown to possess cytostatic and anti-inflammatory activity as well as mutagenic antimutagenic properties.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.