Withania somnifera (Ginseng indien) : vertus médicinales en extraction alcoolique

Withania somnifera (Ginseng indien, Ashwaghanda, Indian ginseng, Ashwagandha) — famille Solanacées.

Synonymes scientifiques : Physalis somnifera-L, Withania kansuensis –Kuang & A M Lu, W microphysalis-Suess..

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 24 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 409 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Racine. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Bhattacharya SK (2003)

     Extrait Withania somnifera (WS) Dunal is classified in Ayurveda, the ancient Hindu system of medicine, as a Rasayana, a group of plant-derived drugs reputed to promote physical and mental health, augment resistance of the body against disease and diverse adverse environmental factors, revitalize the body in debilitated conditions & increase longevity. CS induced significant hyperglycaemia, glucose intolerance, increase in plasma corticosterone levels, gastric ulcerations, male sexual dysfunction, cognitive deficits, immunosuppression & mental depression.

   • Selon Uday Kumar J (2009)

     Extrait Treatment of the diabetic rats with WSREt, WSLEt & Glibenclamide restored the changes of the above parameters to their normal level after eight weeks of treatment, indicating that WSREt & WSLEt possess hypoglycaemic & hypolipidaemic activities in alloxan-induced diabetes mellitus (DM) rats. Hypoglycaemic & hypolipidaemic effects of WSREt & WSLEt were also investigated in alloxan-induced diabetic rats.

   • Selon Jatwa R (2009)

     Extrait Dexamethasone (1.0 mg/kg, i.m.) administration caused hyperglycemia with a parallel increase in renal lipid peroxidation (LPO), relative risk ratio (RR), and the concentrations of serum insulin; total cholesterol (TC); low-density lipoprotein cholesterol (LDL-C); very low-density lipoprotein cholesterol (VLDL-C) & triglycerides (TG). While oral administration with either Withania somnifera (1.4 g/kg) or Bauhinia purpurea (2.5 mg/kg) extract along with dexamethasone and metformin elevated the concentrations of circulating T3 & T4 to euthyroid level.

   • Selon Mukherjee PK (2021)

     Extrait Materials & methods: The sources of information used in the study are traditional Ayurvedic books like Charaka Samhita, Susruta Samhita, Astanga Hridaya etc, government reports, dissertations, books, research articles & databases like Science-Direct, SciFinder, Web of Science, PubMed, Wiley Online Library, & ACS Publications on Ashwagandha & Withania somnifera (L.) Dunal. Withania somnifera (L.) Dunal, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for more than 3000 years.

   • Selon Heba Nageh (2023)

     Extrait Thirty-six male albino rats were randomly grouped into two main groups: normal (n=18) é diabetic (n=18), diabetes was induced by a single dose of 150 mg/kg BW alloxan injected intraperitoneally. In conclusion, ASW root extract can be used to ameliorate the brain oxidative stress and depression brought on by diabetes mellitus at doses of 100 and 200 mg/kg BW.

2. 2

   Cancer : traitement adjuvant de l’adénocarcinome pulmonaire, mammaire métastasé, utérin & du neuroblastome

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Yang Z (2013)

     Extrait Withania somnifera root extracts (WRE) have anti-proliferative activity & the active component, Withaferin A, inhibits the pro-metastatic protein, vimentin. In both models, sWRE & Withaferin A showed dose-dependent inhibition of tumor growth & metastatic lung nodule formation with minimal systemic toxicity.

   • Selon Nile S (2021)

     Extrait The obtained results demonstrated that ashwagandha EE with high concentration of bioactive compounds could act as potential drug candidates against pro-inflammatory enzymes involved in development of inflammation & progression of lung cancer. Further, extensive research is needed to investigate the WS bioactive compounds responsible for treating inflammation, oxidative stress & lung cancer,.

   • Selon Vashi R (2021)

     Extrait They found ashwagandha to exhibit anti-apoptotic, anti-metastatic, anti-invasive & anti-inflammatory properties & gave the evidence that ashwagandha has a capability for averting & treating breast cancer. Aim of the study: This review aims to provide experimental evidence along with a deeper insight into molecular mechanisms of Ashwagandha through which it acts as a chemotherapeutic agent against different types of breast cancer.

   • Selon Moustafa EM (2022)

     Extrait WS extract may be a significant adjuvant in the course of radiotherapy, contributing to the termination of tumor progression, & thus providing cure insights into the molecular mechanisms of lung CSCs intervention. The aim of this study is to assess the inhibitory potential of ethanol extract of Withania somnifera (WS); 500 mg/kg body-weight/day and 8 Gy of ionizing radiation (IR) could inhibit the stemness gene & confer the radiosensitizing effect of WS extract in the female rat LC model.

   • Selon AL-AWADH AA (s.d.)

     Extrait Withania somnifera (L.) Dunal has been extensively studied against various tumor cell lines from different body organs, rarely from the oral cavity. somnifera fruits (W-F) & roots (W-R) hydromethanolic extracts & their chromatographic fractions against oral squamous cell carcinoma (OSCC) cell lines [Ca9-22 (derived from gingiva), HSC-2, HSC-3, and HSC-4 (derived from tongue)] & three normal oral mesenchymal cells [human gingival fibroblast (HGF), human periodontal ligament fibroblast (HPLF), & human pulp cells (HPC)] in comparison to standard drugs.

3. 3

   Stress oxydatif

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Hussain A (2021)

     Extrait somnifera roots have markedly subsided inflammation & improved health through modulating pro-/anti-inflammatory cytokine expression & reducing oxidative stress,. This study aimed to evaluate the anti-arthritic activity of Ricinus communis leaves' & Withania somnifera roots' hydroalcoholic extracts in Complete Freund's adjuvant-induced arthritis in Wistar rats.

   • Selon Afewerky HK (2022)

     Extrait Following an intra-gastric gavage administration of synthesized WS roots methanolic extract from postnatal day 30 (P30) to P75, in vivo cognitional studies and then neurochemical examinations of the NCX3 expression level, Aβ plaque deposition, and antioxidant activities in the AD-associated brain regions of 4-month-old 5xFAD mice suggests that the oxidative stress normalizing effects of WS constituents, operating on the NCX3, may have a therapeutic role in the improvement of cognition in AD,. Withania somnifera, a traditional indigenous plant widely recognized for having numerous medicinal values, was undertaken to determine its potential therapeutic benefit against aggregated Aβ 1–42 -induced NCX3 dysregulation & the thereof cognition impairment in 5xFAD mice.

   • Selon Kumar S (2010)

     Extrait These results demonstrate the neuroprotective properties of an aqueous extract of WS root & may provide some explanation for the putative ethnopharmacological uses of WS for cognitive & other neurodegenerative disorders that are associated with oxidative stress. Withania somnifera L.

   • Selon Khan MA (2019)

     Extrait This increased oxidative stress in the arthritic rats appears to be the outcome of both an activated pro-oxidant & a poor antioxidant defense system. Withania somnifera is one of the most precious medicinal herbs, reported to have antioxidant, anti-inflammatory, & immunomodulatory properties.

   • Selon Ahmad MK (2010)

     Extrait To investigate the impact of Withania somnifera roots on semen profile, oxidative biomarkers, & reproductive hormone levels of infertile men. Conclusion(s): The treatment with WS effectively reduced oxidative stress, as assessed by decreased levels of various oxidants & improved level of diverse antioxidants.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.