Citrus aurantium (Zoranj-anmè) : vertus médicinales en extraction alcoolique

Citrus aurantium (Zoranj-anmè, Orange amère, Bigaradier, Néroli, Bitter orange, Bitter orange tree, Neroli) — famille Rutacées.

Synonymes scientifiques : Aurantium x acre Mill., Aurantium x bigarella Poit. & Turpin, A x corniculatum Poit. & Turpin, A x corniculatum Mill., A x coronatum Poit. & Turpin, A x orientale Mill., A x sykvestre Pritz., Citrus x amare Linn, C x aurata Risso, C x benikoji Yu. Tanaka, C x bigaradia Loisel, C x calot Lag., C x communis Poit. & Turpin, C x dulcimedulla Pritz, C x dulcis Pers..

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 11 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 138 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Troubles hépatiques : cirrhose, cholestase, fibrose hépatique, normalisation des paramètres sériques : ALT, AST, Bilirubine, etc

   Partie usitée : Pelure du fruit. Profil pharmacologique documenté : Silymarine-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Lim SH (2016)

     Extrait To evaluate the possible protective effect of Citrus aurantium peel extract (CAE) against apoptosis in cholestatic liver fibrosis induced by bile duct ligation in mice. Mice were sacrificed & liver fibrosis was evaluated by serum & hepatic tissue biochemistry & liver histopathological examination.

   • Selon Pallavi M (2021)

     Extrait Altogether, lime & sour orange peel extracts were found to be effective against hyperlipidemic parameters such as TC, TG, LDL-C, VLDL-C, & TC/HDL-C & LDL-C/HDL-C ratios, & athrogenic index, in addition to the increased levels of HDL-C. Remarkably, lime peel extract followed by sour orange & orange at 500 mg kg-1 dose improved hepatic architecture to near normal with less deposition of fat globules & fewer sinusoids.

   • Selon Hamedi A (2020)

     Extrait Forty-eight hours after the last administration, serum & liver samples were prepared and alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) & glutathione (GSH) were determined. This study aimed to investigate the effect of the essential oil from CA & lowers on liver health parameters in a laboratory animal model.

   • Selon Ben-Hsouna A (2018)

     Extrait p-EOCa in CCl4 treated rats alleviated hepatotoxicity as monitored by the improvement of hepatic oxidative stress biomarkers levels plasma biochemical parameters, & DNA molecule aspect. The present study aimed (1) to investigate the chemical composition as well as the anti-inflammatory properties & in vitro antioxidant activity of Citrus aurantium peel essential oil (pEOCa) & (2) to evaluate its potential effect in vivo.

   • Selon Almakai WA (2021)

     Extrait The CAEO is an essential oil extracted from Citrus aurantium flowers, have been studied in relation to liver damage done by ischemia/reperfusion (I/R). Following I/R, hepatic lipid peroxidation, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels was increased, though hepatic glutathione content was reduced, CAEO has ameliorated these changes.

2. 2

   Cancer : traitement adjuvant du carcinome : mammaire hormono-dépendant, colorectal, ostéosarcome

   Partie usitée : Pelure du fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Goo L (2022)

     Extrait We demonstrated its application for isolation of phenolic compounds with anti-proliferative activity against colorectal cancer cells (CRCs) from Citrus aurantium L.

   • Selon Camardo L (2007)

     Extrait The antiproliferative activity of fresh fruit juices extracted from Citrus sinensis (cv. myrtifolia , was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) & MCF-7 (human breast adenocarcinoma) cell lines.

   • Selon El-Kersh DM (2021)

     Extrait The ethanolic extract of different varieties of citrus peels along with eight isolated flavonoids were screened against estrogen-dependent breast cancer cell lines besides normal cells for evaluating their safety profile. Overall, this study suggests an antitumor potential for naringenin, naringin & quercetin isolated from citrus peels in breast cancer via possible modulation of estrogen signaling & aromatase inhibition suggesting their use in pre- & post-menopausal breast cancer patients, respectively,.

   • Selon Wang L (2014)

     Extrait This review systematically summarized anticarcinogenic effect of citrus flavonoids in cancer therapy, together with the underlying important molecular mechanisms, in purpose of further exploring more effective use of citrus peel flavonoids. PMFs inhibit carcinogenesis by mechanisms like blocking the metastasis cascade, inhibition of cancer cell mobility in circulatory systems, proapoptosis, & antiangiogenesis.

   • Selon Odeh F (2012)

     Extrait In conclosion, CA peels Eos obviously reduced the cell viability & it might have cytotoxic effect against colorectal cancer cell line. Citrus essential oils (EOs) contain different terpens that have been shown to possess antitumor effects.

3. 3

   Vulvovaginite post-menauposée

   Partie usitée : Pelure du fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Malleshappa P (2018)

     Extrait The present study was contemplated to evaluate the anti-inflammatory & analgesic potentials in peels of some commercially grown Citrus fruits of South India viz, Lime (Citrus aurantifolia), Orange (Citrus reticulata), Sour Orange (Citrus aurantium), Pomelo (Citrus grandis) & Citron (Citrus medica). The extracts obtained were screened for the presence of phytoconstituents by qualitative phytochemical analysis; the anti-inflammatory activity of extracts at 250 & 500mg/Kg body weight concentrations were assessed by in vivo Carrageenan induced rat paw edema model & in vitro HRBC membrane stabilization assay whereas Tail immersion & Hot plate methods have been used to evaluate their analgesic property.

   • Selon Khodabakhsh P (s.d.)

     Extrait The analgesic & anti-inflammatory properties of Citrus aurantium L. The analgesic activity of neroli was assessed by acetic acid-induced writhing and Eddy's hot plate methods, while acute & chronic anti-inflammatory effects were investigated by inflammatory paw edema in rat & the cotton pellet-induced granuloma tissue model, respectively.

   • Selon Almakai WA (2021)

     Extrait The CAEO is an essential oil extracted from Citrus aurantium flowers, have been studied in relation to liver damage done by ischemia/reperfusion (I/R). CAEO was found to have antioxidant, anti-inflammatory, & anti-apoptotic properties that defend against I/R-induced hepatocellular damage.

   • Selon Lai CS (2013)

     Extrait These inhibitory effects were accompanied by mechanistic down-regulation of the protein levels of inflammatory enzymes (inducible nitric oxide synthase, iNOS & cyclooxygenase-2, COX-2), metastasis (matrix metallopeptidase-2, MMP-2 & MMP-9), angiogenesis (vascular endothelial growth factor, VEGF), & proliferative molecules, as well as by the induction of apoptosis in prostate tumors. Our previous studies demonstrated that oral administration of Gold Lotion (GL), an extract of multiple varieties of citrus peels containing abundant flavonoids, including a large percentage of polymethoxyflavones (PMFs), effectively suppressed azoxymethane (AOM)-induced colonic tumorigenesis.

   • Selon Asghar-poor H (2024)

     Extrait This study aimed to evaluate the effect of Citrus aurantium vaginal cream on vaginal atrophy in postmenopausal women. Citrus aurantium vaginal cream was administered to women diagnosed with vaginal atrophy (based on subjective symptoms of atrophy, descriptive evaluation of the vagina, vaginal pH measurement, & degree of vaginal maturation determined by vaginal smear) every night in the first two weeks & every other night for the second two weeks.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.