Citrus x (Pamplemousse) : vertus médicinales en extraction alcoolique

Citrus x (Pamplemousse, fruit défendu, Grapefruit, forbidden fruit) — famille Rutacées.

Synonymes scientifiques : Citrus grandis var racemosa-(B)-.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 3 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 29 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome mammaire

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Cirmi S (2017)

     Extrait Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus Medica fruits, Citrus fruits extract, cancer, neoplasm, neoplasia, tumor, metastasis, carcinogenesis, proliferation. During the last decades, a huge body of evidence has been accumulated suggesting that Citrus fruits & their juices might have a role in preventing many diseases including cancer.

   • Selon El-Kersh DM (2021)

     Extrait Overall, this study suggests an antitumor potential for naringenin, naringin & quercetin isolated from citrus peels in breast cancer via possible modulation of estrogen signaling & aromatase inhibition suggesting their use in pre- & post-menopausal breast cancer patients, respectively. This study aimed at investigating the antitumor potential of the most potent compounds in citrus peels on breast cancer by exploring their anti-estrogenic & anti-aromatase activities.

   • Selon Li C (2022)

     Extrait Furthermore, essential oils from the four Citrus species reduced the expression levels of interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) & nuclear transcription factor kappa B p65 (NF-κB) to different degrees. The cytotoxicity of the four EO on BV2 microglial cells was determined using the MTT assay (IC50; 321.37-1558.87 μg/mL), wherein Citrus limon essential oil showed the lowest cytotoxicity.

   • Selon Ahmed OM (2022)

     Extrait This study was designed to assess the preventive effect of Citrus limon & Citrus paradisi fruit peel hydroethanolic extracts on the progress of complete Freund’s Adjuvant (CFA)-induced arthritis in male Wistar rats.

2. 2

   Arthrose, arthrite, rhumatisme, oedème

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Chaudhari S (2016)

     Extrait The phytochemical constituents & isolated bioactive compounds of Citrus can be investigated further to develop novel herbal drugs by using reverse pharmacological approaches especially in the treatment of liver diseases, arthritis, malignancies, & other inflammatory diseases. The plant was found to possess significant analgesic, anti-inflammatory, antioxidant, anthelmintic, antibacterial, antifungal, & hypolipidemic properties.

   • Selon Li C (2022)

     Extrait Furthermore, essential oils from the four Citrus species reduced the expression levels of interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) & nuclear transcription factor kappa B p65 (NF-κB) to different degrees. The cytotoxicity of the four EO on BV2 microglial cells was determined using the MTT assay (IC50; 321.37-1558.87 μg/mL), wherein Citrus limon essential oil showed the lowest cytotoxicity.

   • Selon Tsujiyama I (2013)

     Extrait Effects of the extracts on the release of histamine from rat peritoneal exudate cells (PECs) was measured to know anti-allergic activity. In this study, aqueous extracts of peels of best-known citrus fruits namely grapefruit (Citrus paradisi), lemon (C.

   • Selon Ahmed OM (2022)

     Extrait In association, the deleterious histological alterations represented by articular joint inflammatory cells infiltration, fibroblasts proliferation, edema, synovial hyperplasia, pannus formation & cartilage necrosis as well as spleen haemorrhage & lymphocytic necrosis & thymus lymphoblasts proliferation were noticeably alleviated by oral supplementation of arthritic rats with CL & CP fruit peel hydroethanolic extracts for 9 & 18 days. The increased mRNA expression of right ankle joint pro-inflammatory & inflammatory mediators including cyclooxygenase-1 (COX-1), interleukin-1β (IL-1β) & interleukin-6(IL-6) & the decreased mRNA expression of anti-inflammatory cytokine (IL-4) were significantly improved in arthritic rats by oral administration of CL & CO fruit peel hydroethanolic extracts.

   • Selon Cirmi S (2017)

     Extrait Prior to the beginning of the review, Authors defined a checklist for inclusion criteria, thus including articles which meet the following: (i) published on peer-reviewed scientific journals; (ii) Citrus juice used alone; (iii) extracts derived from Citrus juice; (iii) for preclinical studies, an exposure time to Citrus juices & their extracts more than 24 h. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus Medica fruits, Citrus fruits extract, cancer, neoplasm, neoplasia, tumor, metastasis, carcinogenesis, proliferation.

3. 3

   Staphylococcus auricularis : association synergique avec la pelure

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Adham AN (2015)

     Extrait From isolated bacterial strain Staphylococcus auricularis showed highest sensitivity against Citrus limon juice with inhibition zone (22mm), in combination with peel (35mm) & Citrus sinensis in combination form showed inhibition zone (19mm). All used citrus fruits showed antimicrobial activity either alone or in combination of peel & juice extracts against isolated bacterial strain.

   • Selon Barreca D (2013)

     Extrait We also checked the antimicrobial activity of a broad fraction containing all the detected flavonoids obtained by preparative HPLC, in terms of MICs for Staphylococcus aureus. A separation/identification protocol based on RP-LC-DAD–ESI-MS–MS has been employed for the characterisation of the flavonoid fraction of the juice from tangelos (Citrus reticulata× Citrus paradisi) grown in Southern Italy.

   • Selon Bhandari DP (2021)

     Extrait Likewise, citrus peel EO showed antimicrobial activity against tested bacterial strains, albeit marginal. GC-MS analysis showed limonene (63.76-89.15%), γ-terpinene (0.24-6.43%), β-pinene (0.15-6.09%), linalool (0.35-3.5%), sabinene (0.77-2.17%), myrcene (0.74-1.75%), α-terpineol (0.28-1.15%), & α-pinene (0.2-0.58%) as the major constituents of the EO of the Citrus species studied.

   • Selon Chaudhari S (2016)

     Extrait The plant was found to possess significant analgesic, anti-inflammatory, antioxidant, anthelmintic, antibacterial, antifungal, & hypolipidemic properties. The phytochemical constituents & isolated bioactive compounds of Citrus can be investigated further to develop novel herbal drugs by using reverse pharmacological approaches especially in the treatment of liver diseases, arthritis, malignancies, & other inflammatory diseases.

   • Selon Denkova-Kostova R (2020)

     Extrait All EOs had antimicrobial activity against saprophytic (Bacillus subtilis, Penicillium chrysogenum, Fusarium moniliforme, Aspergillus niger, Aspergillus flavus, Saccharomyces cerevisiae) & pathogenic microorganisms (Escherichia coli, Salmonella abony, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans), with the highest inhibitory activity being observed in cinnamon oil, followed by grapefruit zest oil, tangerine zest oil & lemon zest oil; the MIC ranging from 6 to 60 ppm. The demonstrated promising results for the antioxidant & antimicrobial activity of the studied EOs would give reason for their inclusion in the development of bio-preservation strategies for food emulsion preservation.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.