Croton tiglium (Ti piyon-dend) : vertus médicinales en extraction alcoolique

Croton tiglium (Ti piyon-dend, Petit Pignon d’Inde, Small Indian Pignon) — famille Euphorbiacées.

Synonymes scientifiques : Croton arboreus-S, C officinalis-(K)-K, C himalaicus-DGL, Kurkas Tiglium-(L)-Raf, Tiglium officinale-K.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 6 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 52 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer: traitement adjuvant du carcinome mammaire métastasé (fruit mature)

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Song HK (2017)

     Extrait Crotonis fructus (CF), the mature fruits of Croton tiglium L., have been used for the treatment of gastrointestinal disturbance in Asia. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in cancer cell invasion.

   • Selon Kim JY (2015)

     Extrait Tiglium seed is a seed of mature Croton Tiglium containing croton oils, which have been traditionally used as laxative or purgative. Accompanied with phosphorylation of connexin43 (Cx43) & extracellular signal-regulated kinases 1/2 (ERK1/2), Tiglium seed extract inhibited gap junctional intercellular communication (GJIC) associated with tumor-promoting potential.

   • Selon Akbar S (2020)

     Extrait In contrast to the tumor promoting activity of topical croton oil, intralesional administration of emulsified croton oil into established transplants of murine fibrosarcoma caused complete regression of the tumors in mice without any recurrence,. Croton oil is the most violent of all cathartics, half to one drop produces burning in the mouth & stomach, often emesis, several extensive fluid evacuations with colic & tenesmus; toxic doses produce gastroenteritis & collapse.

   • Selon Jiang L (2017)

     Extrait Phytochemical investigation of the ethanol extract from the twigs & leaves of Croton tiglium led to the isolation of two new phorbol esters (1-2) & seven known ones (3-9). Meanwhile, compounds 1-9 were determined for their cytotoxic activities on human lung cancer cell line A549.

   • Selon Gupta DP (2020)

     Extrait In this study, we investigated the effect of Croton tiglium extract (CTE) on the production of pro- & anti-inflammatory mediators in microglia & astrocytes via RT-PCR, Western blot, & nitric oxide assay. CTE significantly inhibited the production of neurotoxic inflammatory factors, including nitric oxide & tumor necrosis factor-α.

2. 2

   Dermatophytose: Trichophyton mentagrophytes, T. rubrum, & Epidermophyton floccosum.

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Lin HC (2016)

     Extrait Dermatophytosis, which is caused mainly by genera of Trichophyton, Epidermophyton, & Microsporum, is a frequent dermatological problem in tropical and subtropical countries. rubrum, & Epidermophyton floccosum.

   • Selon Shahid M (s.d.)

     Extrait This study describes the activity-guided isolation & purification of a novel antimicrobial protein from the seed of Croton tiglium. Antifungal & antibacterial activities were determined after each purification step.

   • Selon Zhang (2022)

     Extrait Croton tiglium Linn. Based on a wide range of biological properties, CT has a wide range of pharmacological effects, such as antitumor, anti-HIV, analgesic, anti-inflammatory & antibacterial effects.

   • Selon Yun JW (2018)

     Extrait Seed of mature Croton tiglium also known as Tiglium seed (TS), has been widely used as a natural product due to its several health beneficial properties including anti-tumor & antifungal activities.

   • Selon Niu GL (2020)

     Extrait As a traditional Chinese medicine, Croton tiglium has the characteristics of laxative, analgesic, antibacterial & swelling.

3. 3

   Constipation

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Hu Jing (2012)

     Extrait Croton oil is the fruit oil of Croton tiglium L., which is well known in folk medicine for the treatment of gastrointestinal (GI) diseases, including constipation, abdominal pain, peptic ulcer, and intestinal inflammation for a long period. On the other hand, atropine (10 microM) & 4-DAMP (10 microM) produced a significant inhibition of contractions caused by croton oil, while either hexamethonium (10 microM) or methoctramine (10 microM) was inactive, implying that the regulatory effects of croton oil on GI motility are mediated via the activation of M3 muscarinic receptor.

   • Selon Akbar S (2020)

     Extrait Ethanol seed extract at a dose of 0.06 mL/30 g was effective as laxative in 100% mice, with an ED50 of 0.027 mL; the laxative effect was partially blocked by atropine. In contrast to the tumor promoting activity of topical croton oil, intralesional administration of emulsified croton oil into established transplants of murine fibrosarcoma caused complete regression of the tumors in mice without any recurrence,.

   • Selon Tsai JC (2004)

     Extrait The effects of ethanol extracts of three Chinese medicinal plants Dahuang (Rheum palmatum L.), Badou (Croton tiglium L.), & Huomaren (Cannabis sativa L.), on ion transport of the rat intestinal epithelia were studied.

   • Selon Niu GL (2020)

     Extrait As a traditional Chinese medicine, Croton tiglium has the characteristics of laxative, analgesic, antibacterial & swelling.

   • Selon Auteur (2014)

     Extrait Croton tiglium seeds, known as Jamālgoṭa in Hindi, Marathi, & Urdu is well-known for its toxicity (severe purgative action). In Ayurvedic texts, the plant is known as Kumbhinī & is used for the treatment of constipation after Śodhana (detoxification process) of the seeds with Godugdha (cow milk).

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.