Cynara cardunculus (Artichaut) : vertus médicinales en extraction alcoolique

Cynara cardunculus (Artichaut, Artichoke) — famille Asteracées.

Synonymes scientifiques : Cynara cardunculus-L, C. Cardunculus, Subsp. Altilis, Subst. Sylvestris..

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 12 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 86 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Acarbose-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Ben Salem M (2017)

     Extrait Forty male Wistar rats were induced to diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w.)). In vivo, the results showed that ethanol extract from the leaves of CS (200-400 mg/kg) decreased significantly (p < 0.001) the α-amylase levels in serum of diabetic rats, respectively associated with significant reduction (p < 0.001) in blood glucose rate of 42,84% & 37,91% compared to diabetic groups after 28 days of treatment, a significant lowered of plasma total cholesterol (T-Ch) by 18,11% & triglyceride (TG) by 60,47%, significantly & low-density Lipoproteins (LDL-C) by 37,77%, compared to diabetic rats, Moreover, the administration of ETOH extract appears to exert antioxidative activity demonstrated by the increase of CAT, SOD & GSH activities in liver, kidney & pancreas of diabetic rats.

   • Selon Auteur (1998)

     Extrait In addition, the stimulation of HMGCoA-reductase activity by insulin was efficiently blocked by the extracts, although other insulin-dependent phenomena, such as increased lactate production, were not influenced. Indeed, Luteolin also efficiently blocked the insulin effect on cholesterol biosynthesis.

   • Selon Nazni P (2006)

     Extrait Nazni P et al, Hypoglycemic & hypolipidemic effect of Cynara Scolymus among selected type 2 diabetic individuals.

   • Selon Loi B (2013)

     Extrait Loi B et al, reducing effect of a combination of Phaseolus vulgaris & Cynara scolymus extracts on food intake & glycemia in rats.

   • Selon -Heidarian E (2011)

     Extrait Hypolipidemic & hypoglycemic effects of aerial part of Cynara scolymus in streptozotocin-induced diabetic rats.

2. 2

   Hépatite, cirrhose, stéatose hépatique, intoxication (chimique ou drogue stupéfiante) avec élévation de l’ALT)

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Ahmadi A (2019)

     Extrait In the present study, the hepatoprotective effects of Cynara scolymus leaf extract against DZN-induced liver injury were examined. The administration of Art extract resulted in not only a significant reduction in serum ALP, AST, ALT, MDA, TNF-α, & protein carbonyl but also an improvement of liver histopathological changes and hepatic CAT and SOD activities as opposed to the DZN group.

   • Selon Rangboo V (2016)

     Extrait Based on recent basic & clinical investigations, the extract of artichoke (Cynara scolymus) leaf has been revealed to be used for hepatoprotective & cholesterol reducing purposes. To compare the role of C scolymus use with placebo in changes in study parameters, multivariate linear regression models were employed indicating higher improvement in liver enzymes & also lipid profile particularly triglycerides & total cholesterol following administration of C scolymus in comparison with placebo use.

   • Selon Ben Salem M (2017)

     Extrait scolymus in alloxan induced stress oxidant, hepatic-kidney dysfunction & histological changes in liver, kidney and pancreas of different experimental groups of rats. In vivo, the results showed that ethanol extract from the leaves of CS (200-400 mg/kg) decreased significantly (p < 0.001) the α-amylase levels in serum of diabetic rats, respectively associated with significant reduction (p < 0.001) in blood glucose rate of 42,84% & 37,91% compared to diabetic groups after 28 days of treatment, a significant lowered of plasma total cholesterol (T-Ch) by 18,11% & triglyceride (TG) by 60,47%, significantly & low-density Lipoproteins (LDL-C) by 37,77%, compared to diabetic rats, Moreover, the administration of ETOH extract appears to exert antioxidative activity demonstrated by the increase of CAT, SOD & GSH activities in liver, kidney & pancreas of diabetic rats.

   • Selon Vigh S (2016)

     Extrait Our experimental data are suggesting that the artichoke could be a good candidate for the complementary treatment of certain human cancers but further studies are needed to shed light on all aspects related to its hormetic dose response & cytotoxic effect not talking about the putative hepatoprotective effect in relation to cancer therapy efficiency. Chemomapping of artichoke (Cynara scolymus L.) leaf extracts revealed novel bioactive compounds with putative antitumor effects & therefore, we set to analyze the cytotoxic effects of aqueous & alcoholic extracts on T-47D & ZR-75-1 human breast cancer cell lines.

   • Selon Speroni E (2003)

     Extrait Efficacy of different Cynara scolymus preparations on liver complaints.

3. 3

   Cancer : traitement adjuvant du carcinome mammaire hormono-dependant

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Vigh S (2016)

     Extrait Chemomapping of artichoke (Cynara scolymus L.) leaf extracts revealed novel bioactive compounds with putative antitumor effects & therefore, we set to analyze the cytotoxic effects of aqueous & alcoholic extracts on T-47D & ZR-75-1 human breast cancer cell lines. Our experimental data are suggesting that the artichoke could be a good candidate for the complementary treatment of certain human cancers but further studies are needed to shed light on all aspects related to its hormetic dose response & cytotoxic effect not talking about the putative hepatoprotective effect in relation to cancer therapy efficiency.

   • Selon Mileo AM (2015)

     Extrait Mileo AM et al, Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line.

   • Selon Yasukawa (2010)

     Extrait The methanol extract of the flowers of artichoke (Cynara cardunculus) exhibited remarkable antitumor activity in an in vivo two-stage carcinogenesis test in mice, using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter.

   • Selon Simsek EN (2013)

     Extrait Apoptotic 1 cytotoxic activity of plant extracts obtaining from naturally growing Cynara syriaca in Turkey & cultivated C cardunculus against DLD1 colorectal cancer cells was determined. Extracts from wild and cultivated Cynara species were obtained from their vegetative parts and receptacles using hexane & applied with five different dose (0.1-1 mg/ml) as well as apigenin for MTT tests for three time periods (24, 48 and 72 hours).

   • Selon Mileo AM (2012)

     Extrait The human breast cancer cell line, estrogen receptor negative, MDA-MB231, was used to evaluate the antitumor effect of polyphenolic extracts from the edible part of artichokes (AEs). Treatment of cancer cells reduced cell viability & inhibited cell growth in a dose-dependent manner.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.