Diospyros kaki (Kaki) : vertus médicinales en extraction alcoolique

Diospyros kaki (Kaki, Persimmon) — famille Ebénacées.

Synonymes scientifiques : Diospyros chinensis-Blume (nom. Nud.).

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 13 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 82 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Arthrite rhumatoide

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Direito R (2020)

     Extrait The persimmon extract showed an anti-inflammatory effect given the significant reduction in both the edema volume & radiological alterations attributed to CIA in the bone. The aim of this work was to evaluate the anti-inflammatory activity of a DK extract in rats with collagen-induced arthritis (CIA).

   • Selon Forouzanfar F (2024)

     Extrait In the present study, the therapeutic effect of Diospyros kaki fruit hydroalcoholic extract (DFHE) on complete Freund's adjuvant (CFA)‐induced arthritis in rats was investigated. These results suggest that DK extract caused an improvement in clinical signs of RA symptoms possibly through suppression of oxidative stress & inflammation.

   • Selon Cho YH (2016)

     Extrait Cho YH et al, Anti-inflammatory potential of quercetin-3-O-bêta-D-("2"-galloyl)-glucopyranoside & quercetin isolated from Diospyros kaki Calyx via suppression of MAP signaling molecules in LPS-induced RAW 264.7 Macrophages.

   • Selon Bawazeer S (2021)

     Extrait The anti-inflammatory potential was measured by using the carrageenan-induced&d histamine-induced paw edema procedure, while the analgesic potential was determined using a hot plate analgesiometer. Anti-inflammatory, analgesic, & sedative medicine is used with numerous side effects, including peptic ulcer, headache, addiction, & other complications.

   • Selon Kim KA (2016)

     Extrait in this study, the beneficial effects of the oral administration of ethanol extract of Diospyros kaki (EEDK) were tested on a mouse dry eye model induced by Benzalkonium chloride (BAC). Moreover, EEDK treatment inhibited the inflammatory response & corneal epithelial cell death in a BAC-induced murine dry eye model, and changes in squamous cells were inhibited.

2. 2

   Cancer : traitement adjuvant du carcinome prostatique

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Hong C (2023)

     Extrait The major chemical constituents of the leaves of Diospyros kaki are flavonoids & triterpenoids, both of which are potential antioxidants that can prevent damage caused by reactive oxygen species or reactive nitrogen species & ameliorate diseases associated with oxidative stress. Experiments have shown that flavonoids or the extracts from the leaves of DK have a variety of good pharmacological activities, which could activate oxidative stress & mitochondrial apoptosis, inhibit the proliferation of human prostate cancer cells & induce apoptosis.

   • Selon Jo KJ (2011)

     Extrait Results from this study demonstrated that methanolic extracts of persimmon calyx (PCE) have cytotoxic effects in human cancer cells. Through MTT reduction assay, lactate dehydrogenase release assay, morphological assay, and colony formation assay, highly cytotoxic effects were demonstrated in human cancer cells treated with various concentrations of PCE.

   • Selon Lee WS (2015)

     Extrait Lee WS et al A polysaccharide fraction from the leaves of Diospyros kaki (PLE0) has an antimetastatic effect by inhibiting MMP-2/9 via downregulation of NF-κB & AP-1 signaling in colon cancer, Inter Symposium & Annual Meeting, 2015.8, 405.

   • Selon Forouzanfar F (2024)

     Extrait In the present study, the therapeutic effect of Diospyros kaki fruit hydroalcoholic extract (DFHE) on complete Freund's adjuvant (CFA)‐induced arthritis in rats was investigated. Serum levels of malondialdehyde (MDA), thiol groups, tumor necrosis factor‐alpha (TNF‐α), as well as glutathione peroxidase (GPx) & superoxide dismutase (SOD) activities were evaluated.

   • Selon Park SB (2017)

     Extrait Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail. Methods: Anti-cell proliferative effect of 70% ethanol extracts from the calyx of D kaki (DKC-E70) was evaluated by MTT assay.

3. 3

   Stress oxydatif

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Forouzanfar F (2024)

     Extrait In the present study, the therapeutic effect of Diospyros kaki fruit hydroalcoholic extract (DFHE) on complete Freund's adjuvant (CFA)‐induced arthritis in rats was investigated. These results suggest that DK extract caused an improvement in clinical signs of RA symptoms possibly through suppression of oxidative stress & inflammation.

   • Selon Kim L (2017)

     Extrait The aim of this study was to investigate the protective effects of ethanol (EAP) and acidic ethanol extracts (AEAP) of astringent Persimmon fruits (Diospyros kaki) against hydrogen peroxide (H2O2)-induced oxidative stress in Caco-2 epithelial cells. These results demonstrated that astringent Persimmon fruit extracts were biologically active, and that the tannin-rich fraction (AEAP) possesses stronger protective activity against H2O2-induced oxidative stress in Caco-2 cells.

   • Selon Hwang KA (2017)

     Extrait Taken together, our results indicate that astringent Persimmon regulate cholesterol accumulation by inhibiting the oxidative stress and controlling the levels of LDL & HDL-associated gene. This study aimed to investigate the effects of ethanol extract of astringent Persimmon on antioxidant activity, cholesterol, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity, and mRNA expression of cholesterol metabolism-related genes in human hepatoma cell line (HepG2 cells).

   • Selon Forouzanfar F (2016)

     Extrait Diospyros kaki (Persimmon) has been shown to exert anti-inflammatory, antioxidant, & antineoplastic effects. Here, we used an in vitro model of cerebral ischemia & studied the effects of hydroalcoholic extract of peel (Pe HE) & fruit pulp (Pu HE) of Persimmon on cell viability & markers of oxidative damage mainly intracellular reactive oxygen species (ROS) induced by glucose-oxygen-serum deprivation (GOSD) in PC12 cells.

   • Selon Jang LC (2010)

     Extrait This study was conducted to determine the antioxidant activities & the antigenotoxic effects of acetone, ethanol, methanol and water extracts from four different parts (calyx, seed, peel and flesh) of persimmon fruits. This study also showed that ethanol was more effective on the extraction of antioxidant compounds from persimmon compared to other solvents.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.