Ocimum gratissimum (Fonbazen) : propiedades medicinales en extracción alcohólica

Effects of three plants extract (Ocimum gratissimum, Acalypha wilkesiana & Acalypha Macrostachya) on post-harvest pathogen of Persea Americana. J. Med Plants Res 2008; 2: 311-4.- Abstract: Disease assessment of Persea americana (Avocado) in a local market in Delta State Nigeria showed that only 7% of the fruits were healthy. 36% of the Avocado fruits had Cercospora spot; 28% had Diotherella rot & 29% had anthracnose. Plant extracts of three different species; Ocimum gratissimum, Acalypha wilkesiana & A Macrostachya were assessed for inhibitory effect on the radial growth of Cercospora purpu…

Control of Anthracnose disease of cowpea by Cymbopogon citratus Ocimum gratissimum. Acta Phyto Pathol Entomol. Hungarica 34 (1-2): 85-9, 1999.

Abstract: Due to the continuous and misuse of synthetic insecticides which led to development of insecticide resistance, the present study was to determine the mosquito larvicidal activity of Lantana camara and Ocimum gratissimum leaf extracts in individual and combined forms to explore eco-friendly plant extracts that have potentials to suppress mosquito larval population. Recommended WHO mosquito larval bioassay method for insecticide was used. Four concentrations ranging from 0.25 to 2 g/L were performed for all extracts and fractions in single and combined forms. In single…

Antioxidative properties of Ocimum gratissimum alters Lead acetate induced oxidative damage in lymphoid tissues & hematological parameters of adult Wistar rats, Pharmacol Rep, 8:215-22. 2021-Abstract: Lead exposure is a well-known environmental hazard. Its accumulation in humans may pose a danger to health. The present study investigated the beneficial effect of Ocimum gratissimum extract (OG) in reducing lead acetate (LA) induced oxidative damage in the spleen, thymus, & hematological indices. We employed an in vivo model of LA induced Wistar rats & administered 125 mg/kg/bw & 250 mg/kg/bw…

Immunostimulatory Activity of Ethanolic Leaf Extract from Ocimum gratissimum in Albino Rat Orogastric ally Dosed with Escherichia coli (NCIB 86). J of Pharmacol & Toxicology, 1: 389-94, 2006-Abstract: Immunostimulatory activity of ethanolic leaf extract of Ocimum gratissimum was investigated in albino rats using immunologic/ Haematologic indices. The rats were dosed orally with standard inoculum of Escherichia coli (NCIB 86) of 1x107 cfu mL-1. The extent of infection was carried out by checking the Haematologic indices before, during & after treating the infection with ethanolic extract of …

Antifungal effects of two tropical plant leaf extracts (Ocimum gratissimum & Aframomum meleguetta) on postharvest Yam (Dioscorea spp.) rot, Afr Jl of Biotechnol, 5 (9) :727-31, 2006.-Abstract : Effects of leaf extracts of Ocimum gratissimum & Aframomum melegueta on spore germination and mycelial reduction of the most occurring fungal pathogen causing soft rot of Yam tuber were investigated. Fungi isolated from rotted yams were Aspergillus niger, A. flavus, Fusarium oxysporum Rhizopus stolonifer, Botryodiplodia theobromae & Penicillium chrysogenum. The leaf extracts with ethanol extraction …

Chemical composition & effects of Ocimum gratissimum essential oil (OGEO) on the expression of mRNA for antioxidant enzymes during in vitro culture of bovine ovarian secondary follicles. Jl of Essential Oil Res, 2022, 34 (5), 446-54-Abstract: This study analyzed the chemical composition of OGEO & its effects on growth, viability, antrum formation & mRNA expression for superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) & peroxiredoxin 6 (Prdx6) in bovine secondary follicles cultured in vitro. The follicles were cultured in TCM-199+ alone or supplemented with 0.125, 0.25…

In vivo antimalarial activity of essential oils from Cymbopogon citratus & Ocimum gratissimum on mice infected with Plasmodium berghei. Planta Med. 2005;71(1):20-3.-Abstract: The essential oils obtained by hydrodistillation from fresh leaves of Cymbopogon citratus & Ocimum gratissimum growing in Cameroon were analyzed by GC & GC/MS. The main constituents of the oil of Ocimum gratissimum were gamma-terpinene (21.9 %), beta-phellandrene (21.1 %), limonene (11.4 %) and thymol (11.2 %), while the oil of C citratus contained geranial (32.8 %), neral (29.0 %), myrcene (16.2 %) & bêta-pinene (10.5…

Attenuation of PI3K/AKT signaling pathway by Ocimum gratissimum leaf flavonoid-rich extracts in streptozotocin-induced diabetic male rats, Biochem Biophys Rep, 16:38:101735. 2024-Abstract: Diabetes is a group of medical conditions characterized by the body's inability to effectively control blood glucose levels, due to either insufficient insulin synthesis in type 1 diabetes or inadequate insulin sensitivity in type 2 diabetes. According to this research, the PI3K/AKT pathway of Ocimum gratissimum leaf flavonoid-rich extracts in streptozotocin-induced diabetic rats was studied. We purchased…

Effect of Solvent Extracts of Some Plants on Ralstonia solanacearum, Microbiol Res Jl Inter, 4(1), 89–96. 2013-Abstract: To study the efficacy of different solvent extracts (chloroform, ethanol, methanol & hexane) of ten plants on Ralstonia solanacearum the causal organism of bacterial wilt of tomato. Place & Duration of Study: Departments of Crop Production, Soil & Environmental Management & Biological Sciences, Bowen University, Iwo, Nigeria from August 2011 to April 2012. Methodology: Ten plants namely Ocimum gratissimum (leaf), Vernonia amygdalina, Allium sativum (bulb), Zingiber offici…

Antileishmanial activity of eugenol-rich essential Oil from Ocimum gratissimum. Parasitol. Int., 55: 99-105.2006.-Abstract: Leishmaniasis is a group of diseases with a large spectrum of clinical manifestations caused by protozoans of the genus Leishmania. Here we demonstrate the leishmanicidal activity of the essential oil of Ocimum gratissimum as well as its main constituent, eugenol. The eugenol-rich EO of OG progressively inhibited Leishmania amazonensis growth at concentrations ranging from 100 to 1000 microg/ml. The IC50 (sub-inhibitory concentration) of the essential oil for promastig…

Can antimalarial, antiviral & anti-respiratory infections Cameroonian medicinal plants be used as one of the potential ways to cure COVID-19?, Pharmacological & Ethnomed proof, Jl of Med Herbs & Ethnomedicine, 2020--Abstract:  This research work presents the findings of an investigation on traditional Cameroonian remedies of respiratory tract infections, malaria & viral infections, & also recipes that could serve as a baseline for the prevention, alleviate symptoms, treatment & perhaps may help for the anti-COVID-19 drugs discovery. Data-t-on the medicinal plants were collected from traditio…

bleeding & clotting time effects of ethanol extract of Chromolaena odorata versus Ocimum gratissimum treated Albino rats, Com J Med Sci, 2:9-13, 2014-Abstract: In view of the traditionally acclaimed wound healing & hemostatic properties of Chromolaena odorata & Ocimum gratissimum respectively, this study investigated the effects of ethanol extracts of the leaves of both plants on bleeding & clotting times in albino rats. The extracts were administered to the rats by oral gavage at doses of 150mg/kg & 300mg/kg body weight daily for 14 days, while a non- treated group & another group treated …

Effects of Ocimum Gratissimum Leaves on Common Dermatophytes & Causative Agent of Pityriasis Versicolor in Rivers State, Nigeria, Jl of Microbiol Res 2012, 2(4): 108-13. Abstract: This antifungal study on O gratissimum is rare in Nigeria and hence this study seeks to justify the ethnobotanical uses of the plant. The antifungal activity of O gratissimum used by traditional medicine practitioners against the three major Dermatophytes – Trichophyton, Microsporum, Epidermophyton together with Malassezia furfur (the cause of Pityriasis versicolor (Eczema)), were studied by well-in-agar diffusion…

Amoebicidal activity of essential oils & essential oil-based microemulsions of Aloysia citriodora Ortega ex Pers., Cymbopogon winterianus Jowitt ex Boor, & Ocimum gratissimum L. against Acanthamoeba polyphaga trophozoites, Microbiol, 135(9): lxae232. 2024-Abstract: Evaluate the in vitro efficacy of the essential oils derived from Aloysia citriodora (Verbenaceae), Cymbopogon winterianus (Poaceae), & Ocimum gratissimum (Lamiaceae) against Acanthamoeba polyphaga trophozoites. Additionally, microemulsions formulated with these essential oils, along with their major components, were analyzed. Me…

Chemical Characterization & Insecticidal Potential of the Essential Oil of Ocimum gratissimum L. (Lamiaceae) Against Nauphoeta cinerea (Blaberidae), Res Soc & Dev, 9(9) :1-16, 2020-Abstract : Plants are considered a rich source of bioactive compounds & an alternative agent for insect control. Among them, representatives of the Lamiaceae family are the best known for this potential, as they produce volatile compounds with insecticidal activities, known as essential oils, as is the case with Ocimum gratissimum. In this way, the present work had as objective, to determine the chemical composi…

Toxicity & gastric tolerance of essential oils from Cymbopogon citratus, Ocimum gratissimum & Ocimum basilicum in Wistar rats, Food & Chem Toxicol, 46 (7) :2493-7, 2008-Abstract: Oils of Cymbopogon citratus, Ocimum gratissimum & Ocimum basilicum are widely used for their medicinal properties, & as food flavors & perfumes. Recently in a study in West Africa, these oils have been recommended to combat Fusarium verticillioides & subsequent fumonisin contamination in stored maize, but their toxicological profile was not investigated. The current study was undertaken to provide data on acute & s…

Effect of Essential Oil of Ocimum gratissimum on the Trypanosomatid Herpetomonas Samuel pessoai, Acta Protozoal. (2003) 42: 269 – 276.-Summary: In this study, we reported the effect of the essential oil of Ocimum gratissimum on Herpetomonas Samuel pessoai, a non-pathogenic Trypanosomatid. Parasites were grown at 28 or 37°C, in a chemically defined or a complex medium, containing essential oil obtained from Ocimum gratissimum. At concentrations from 20 to 250 µg/ml, the essential oil, progressively inhibited the protozoan growth. The IC50, in defined & complex media, at 28°C were 100 & 91 µg…

Chemistry & bioactivities of essential oils of some Ocimum species: an overview, Asian Pac Jl of Trop Biomed, 4(9):682-94, 2014-Abstract: Essential oils of different species of the genus Ocimum are natural flavouring materials of commercial importance. The data given in current literature are pertaining to the chemical composition of essential oils of different Ocimum species viz., Ocimum basilicum Linn. (alt. OB var. minimum, OB var. purpurience), Ocimum campechianum Mill., Ocimum canum Sims. (O americanum), Ocimum citriodorum, Ocimum gratissimum Linn., Ocimum kilimandscharicum Linn., Ocim…

Ocimum gratissimum leaf extract ameliorates phenylhydrazine-induced anaemia & toxicity in Wistar rats, Drug Met Pers Ther, 2021-Abstract: Ocimum gratissimum L. is used in traditional medicine for the treatment of bacterial infections & anaemia. This study was designed to evaluate the effect of O. gratissimum leaf extract on phenylhydrazine (PHZ)-induced anaemia & toxicity in rats. Methods: The experimental rats were divided into five groups (A-E) (n=6/sex/group). Each rat in groups B-E was intraperitoneally administered 50 mg/kg of PHZ for two consecutive days. Group A (normal control) did …

Studies on the acute & subchronic toxicity of the essential oil of Ocimum gratissimum L. Leaf, Phytomed, 11(1): 71-6, 2004-Abstract: Oral & intra-péritonéal acute toxicity and the subchronic intra-péritonéal toxicity of the essential oil of Ocimum gratissimum Linn, Lamiaceae (Ocimum oil), was investigated. The acute toxicity test involved the oral & intra-péritonéal administration of graded doses of Ocimum oil prepared as a 4% v/v emulsion to 2 groups each of 30 rats & mice. LD50 & LD100 were determined for both routes & species. In the subchronic toxicity study, 25 male Sprague-Dawley rats…

Antinociceptive properties of essential Oil of Ocimum gratissimum L. in mice. Braz. Jl Med. Biol. Res. 36: 521-4, 2003.-Abstract: We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiateae) (EOOG) in two Classical models of pain in male Swiss mice (25-35 g), the writhing test & the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (from 58.3 ± 4.4 to 40.7 ± 6.3, 36.4 ± 3.6 and 24.6 ± 3.6, respectively; N = 8-10, P<0.05) of acetic acid-induced writhing, causing up to a ~60% inhibition at the highest…

Effects of seasonal variation on the central nervous system activity of Ocimum gratissimum L essential Oil. Jl Ethnopharmacol, 105: 161-6, 2006-Abstract: Ocimum gratissimum L. (Lamiaceae) and other species of the same genus are used as medicines to treat central nervous system (CNS) diseases, commonly encountered in warm regions of the world. The chemical composition of O gratissimum essential oil varies according to their chemotypes: timol, eugenol or geraniol. In this study, the essential oil type eugenol was extracted by hydrodistillation in each of the four seasons of the year. Activity…

Evaluating Water bitter leaf (Struchium sparganophorum) & Scent Leaf (Ocimum gratissimum) extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model, Drug & Chem Toxicol, 46(2):236-46. 2023-Abstract: Tropical vegetables remain one of the major sources of functional foods & nutraceuticals, while their constituent phytochemicals, especially alkaloids, have been reported to exhibit neuroprotective properties. Here, the protective effect of alkaloid extracts from Scent leaf (Ocimum gratissimum) & Water bitter leaf (Struchium sparganophorum) on manganese (Mn)- in…

Moringa oleifera, Ocimum gratissimum & Vernonia amygdalina as a Natural Antiparasitic Alternative in Growing Rabbits. Livest. Res. Rural Dev. 2021, 33, 1–7-Abstract:  This study aims to assess the activity of Moringa oleifera, Ocimum gratissimum & Vernonia amygdalina on the elimination of coccidia cysts & helminth eggs in rabbits. 40 New Zealand rabbits, 60 days old & 1100 ± 122g body weight and naturally infected were used. The rabbits were assigned to forth groups of ten rabbits per group. The first three groups: Mo, Og & VA received respectively Moringa oleifera, OG & Vernonia amygdalina…

Chemical Composition & Spectrum of Insecticidal Activity of the Essential Oils of Ocimum gratissimum L. & Cymbopogon citratus Stapf on the Main Insects of the Cotton Entomofauna in Côte d’Ivoire, Biodivers, 18(11): e2100497. 2021-Abstract: Among the alternatives to environmentally toxic & socio-economically unacceptable chemical pesticides, essential oils from Ocimum gratissimum & Cymbopogon citratus were tested on the main pests & beneficial insects of the cotton plant in Côte d'Ivoire. After extraction & chemical analysis of the essential oils, field trials were carried out using a Fisher…

Vascular permeability increasing effect of the leaf essential oil of Ocimum gratissimum Linn as a mechanism for its wound healing property. Afr J Trad CAM. 2: 253–8 (2005). -Abstract: Persistent microvascular hyperpermeability to plasma proteins is a characteristic feature of normal wound healing. Does the leaf essential oil of O gratissimum Heal wounds by promoting this feature? Evan’s blue dye (20mg/kg body weight) in normal saline was administered intravenously through marginal ear vein of experimental rabbits (n=5). Each animal served as its own control. One hour after Evan’s blue dye a…

Analgesic Effect of Aqueous & Hydroalcoholic Extracts of Three Congolese Medicinal Plants : Hyptis suaveolens, Nauclea latifolia & Ocimum gratissimum, Pak Jl of Biol Sci, 7(9) :1613-5, 2004.-Abstract : Analgesic effect of aqueous and hydroalcoholic extracts of aerial parts of Hyptis suaveolens, Nauclea latifolia and Ocimum gratissimum, three plants used in Congolese folk medicine in pain, were tested on acetic acid and hot plate-tests. All extracts manifest analgesic effect on the two models used. The more active was the hydroalcoholic extract of Ocimum gratissimum which is not antagonized …

In Vitro Antioxidant Activity & In Vivo Antidepressant-like Effect in Mice of the Ethanolic Extract from Leaves of Ocimum gratissimum Linn., Jl Nat Sci, 13(3) :297, 2014-ABSTRACT: This paper investigated the antioxidant activity and antidepressant-like effect of ethanolic leaf extract of Ocimum gratissimum (OGE). In vitro antioxidant activity of OGE was assessed in three complementary test systems: DPPH (1, 1-Diphenyl-2-picrylhydrazyl), nitric oxide scavenging activity and reducing power assay. The antidepressant-like effect of OGE was investigated in mice using the forced swim test (FST) a…

The aqueous extract of Ocimum gratissimum leaves ameliorates acetic acid-induced colitis via improving antioxidant status & hematological parameters in male Wistar rats Egyptian J of Basic & Applied Sci, 5:3, 2018-Abstract: This study investigated the protective effects of aqueous extract of Ocimum gratissimum leaves (AEOGL) on acetic acid induced colitis in male rats. Twenty male Wistar rats, 100–180 g were divided into four groups as follows: Group 1 (control) (n = 5) received 2 ml/kg of distilled water for 21 consecutive days. Group 2 (n = 5) received 2 ml of 6% acetic acid solution once…

Comparative Studies on in Vitro Free Radical Scavenging Activity of Aqueous, Ethanol, Ethyl acetate & N-Hexane Extracts of Leaves of Datura stramonium & Ocimum gratissimum, Semantic Scholars, Corpus ID : 54041279, 2015-Abstract : The in vitro Free Radical Scavenging Activity of aqueous, ethanol, ethyl acetate & n-hexane extracts of leaves of Datura stramonium & Ocimum gratissimum were investigated. Due to the fact that Free radicals are implicated in many diseases including diabetes mellitus, arthritis, cancer, ageing. etc. In the treatment of these diseases, antioxidant therapy has gained …

Action du fongicide naturel NECO contre la cercosporiose noire (Mycosphaerella fijiensis Morelet) chez le Bananier plantain (AAB) en Côte d’Ivoire, Jl of Applied Bio-Sci, 75:6153-91, 2014.-Abstract: The present study was to determinate effect of a natural fungicide coded NECO on Mycosphaerella fijiensis severity, fungi responsible of the black Sigatoka disease (BSD) on two cultivars of plantain (Corne 1 & Orishele) in natural infection condition. Methodology & Results: NECO was obtained by extraction of essential oil from fresh leaves of Ocimum gratissimum & sprayed in a mixture with Banole…

Preliminary phytochemical analysis & insecticidal activity of ethanolic extracts of four tropical plants (Vernonia amygdalina, Sida acuta, Ocimum Gratissimum & Telfaria occidentalis) against beans weevil (Acanthscelides obtectus), Inter J of the Physical Sci, 5(6) : 753-62, 2010.-Abstract : Ethanolic extracts of the leaves of Ocimum gratissimum, Sida acuta, Telfaria occidentalis & Vernonia Amygdalina were screened for secondary metabolite constituents and insecticidal activity against beans weevil (Acanthscelides obtectus). Phytochemical screening of the extracts revealed the presence of a…

Chemical investigation of Ocimum species Growing in Togo. Flav. Frag. Jl., 13: 226-32, 1998.

Ocimum gratissimum aqueous extract induces apoptotic signaling in lung adenocarcinoma cell A549. Evidence-Based Comp & Alter Med., 2010-Abstract: Ocimum gratissimum (OG) is widely used as a traditional herb for its antibacterial activity in Taiwan. Recently, antitumor effect of OG on breast cancer cell is also reported; however, the effects of OG on human pulmonary adenocarcinoma cell A549 remain unclear. Therefore, we aimed to investigate whether aqueous OG extract (OGE) affects viability of A549 cells & the signals induced by OGE in A549 cells. Cell viability assays revealed that OGE sign…

Hypoglycaemic activity of Ocimum gratissimum in rats. Fitoter, 71: 444-6, 2000-Abstract: The hypoglycaemic effect of the methanolic extract of Ocimum gratissimum leaves was evaluated in normal and alloxan-induced diabetic rats. Intraperitoneal injection of the extract (400 mg/kg) significantly reduced plasma levels both in normal & diabetic rats by 56 & 68%, respectively.

The effects of aqueous Ocimum gratissimum leaf extract on some biochemical and hematological parameters in male mice. Asian J Biol Sci. 2011; 4:44–52

Ocimum gratissimum Linn. Leaves reduce the key enzymes activities relevant to erectile dysfunction in isolated penile & testicular tissues of rats, BMC Comp & Alter Medicine, 19(71) : 2019-Abstract : Ocimum gratissimum L. is a medicinal plant widely grown in tropical & subtropical regions with the leaf decoction usually taken in folk medicine to enhance erectile performance in men although the probable mechanism of actions remains undetermined. This study examined the inhibitory potentials of O gratissimum leaves on some key enzymes associated with erectile dysfunction in penile & testicula…

Evaluation of the antioxidant activity of Ocimum sp. Jl. Food Technol., 4: 318-21, 2006.

Antifungal activity from Ocimum gratissimum L, towards Cryptococcus neoformans. Mem Inst Oswaldo Cruz. 2005; 100:55–8-ABSTRACT: Cryptococcal infection had an increased incidence in last year’s due to the explosion of acquired immune deficiency syndrome epidemic and by using new & effective immunosuppressive agents. The currently antifungal therapies used such as Amphotericin B, fluconazole, and Itraconazole have certain limitations due to side effects and emergence of resistant strains. So, a permanent search to find new drugs for cryptococcosis treatment is essential. Ocimum gratissimum, p…

Synergistic Activity of a Mixture of Lantana camara & Ocimum gratissimum Leaves Extracts against Aedes aegypti Larvae (Diptera: Culicidae). Jl of Mosquito Res, 6(23), 1-10. 2016-

Pharmacological evidence of calcium-Channel blockade by essential Oil of Ocimum gratissimum and its main constituent’s eugenol, in isolated arotic rings from DOCA-Salt hypertensive rats. Fundam. Clin. Pharm, 21: 497-506, 2007.-Abstract: Intravenous (i.v.) treatment of conscious DOCA-salt hypertensive rats with the essential oil of O gratissimum L. (Labiateae) (EOOG) induced a hypotensive effect that seems related to an active vascular relaxation rather than withdrawal of sympathetic tone. To corroborate this hypothesis, the present study examined the vascular effects of EOOG and its main co…

Comparative in vitro effects of AZT & extracts of Ocimum gratissimum, Ficus polita, Clausena anisata, Alchorne cordifolia & Elaeophorbia drupifera against HIV-1 & HIV-2 infections. Antiviral Res, 58: 25-33, 2003-Abstract: The effects of Ocimum gratissimum (GHX-2), Ficus polita (GHX-6), Clausena anisata (GHX-7), Alchornea cordifolia (GHX-26), Elaeophorbia drupifera (GHX-27), & AZT on in vitro HIV-1 & HIV-2 replication & cytopathicity were compared. All plant extracts inhibited HIV-1 strain HTLVIII(B) cytopathicity, the leaves of GHX-2 & the seeds of GHX-26 having high antiviral indices (110 …

Anthelmintic activity of Ocimum gratissimum leaf extract in Heligmosomoides bakeri infected experimental mice, Annals fl Biol Sci, 3(4) :1-7, 2015-Abstract: The anthelminthic potential of leaf extract of Ocimum gratissimum in H. bakeri infected mice was studied using carefully controlled whole animal experimental model. Results obtained revealed an LD50 value of 2075mg/kg body weight suggest some margin of safety as the extract could well be tolerated at low to moderate doses. High doses could be toxic. The antihelmintic study showed that Ocimum gratissimum leaf extract has strong antihelmi…

Effect of Ocimum gratissimum Leaf-extract on Hematological Indices & Lipid Profile of Streptozotocin-induced Diabetic Wistar Rats, Pak J of Biol Sci, 23(12):1823-9, 2020-Abstract: OG has been used in ethnopharmacology for the treatment of diabetes. The aim of the study was to evaluate the effect of OG leaf-extract on hematological indices & lipid profile of Streptozotocin-induced diabetic Wistar rats. Materials & methods: Twenty-four rats weighing 100-160 g were randomly assigned to four treatment groups, the normal & diabetic controls, received a placebo treatment, while groups three and f…

Effects of aqueous extract of Ocimum gratissimum on haematological parameters of Wistar rats. Biokem-2008; 20:33–7.

Antifertility effects of aqueous crude extract of Ocimum gratissimum L leaves in male mice J of Med Plants Res, 4(9) :809-16, 2010.

Health & therapeutic potentials of Ocimum essential oils: a review on isolation, phytochemistry, biological activities, & future directions Jl of essential Oil Res, 36:3, 2024-Abstract: Ocimum species, including African basil (Ocimum gratissimum) & Holy basil (Ocimum sanctum), are valued for their diverse therapeutic properties particularly in the form of essential oils (EOs). This review provides a comprehensive analysis of the health & therapeutic potentials of Ocimum essential oils, specifically focusing on African & Holy basil. It encompasses various aspects, such as isolation methods, …

The anthelmintic effects of the leaf extract of Ocimum gratissimum (L). Phytomed, 1998; 5 (6): 485 – 8.

Application of Essential Oils of Ocimum gratissimum & Cymbopogon citratus as Bioinsecticides for the Management of Two Major Biting-Sucking Insects (Bemisia tabaci Gennadius & Jacobiella fascialis Jacobi) & the Improvement of Seed & Fiber Quality of Cotton Plants in Ivory Coast, Biodivers, 19(2): e202100801.2022-Abstract:In recent years, in all cotton production areas in Ivory Coast, whitefly (Bemisia tabaci) & jassid (Jacobiella facialis), two biting sucker insects were causing depreciation of quality of the cottonseed & fiber obtained at harvest. However, the excessive use of synthetic ch…

In Vitro & Molecular Docking Evaluation of Larvicidal Effects of Essential Oils of Five Aromatic Plants on the Fall Armyworm Spodoptera frugiperda JE. Smith (Lepidoptera: Noctuidae) from Ivory Coast, Chem Biodivers, 20(8): e202300411.2023-Abstract: Faced with the serious consequences resulting from the abusive & repeated use of synthetic chemicals, today rethinking crop protection is more than necessary. It is in this context that the essential oils of the Lamiaceae Ocimum gratissimum & Ocimum canum, the Poaceae Cymbopogon citratus & nardus & a Rutaceae Citrus sp. of known chemical composit…

Determination of the Anti-nutrient Composition of Ocimum gratissimum, Corchorus olitorius, Murraya koenigii Spreng & Cucurbita maxima, Inter Jl of Innov & Sci Res, 3 (2) :127-33, 2014,-Abstract: The present study investigates the anti-nutrient composition of Ocimum gratissimum, Corchorus olitorius, Murraya koenigii Spreng & Cucurbita maxima following standard methods. Anti-nutritional factors are chemical substances which act to reduce nutrient intake, digestion, absorption & utilization of nutrients which may accumulate in the body to toxic level if the diet is not varied. The qualitative …

Chemical characterization of Basil (Ocimum spp.) found in the markets & used in traditional medicine in Brazil, Econ Bot, 54 :207-216, 2000.

Inhibition of Breast tumor growth & angiogenesis by a medicinal herb: Ocimum gratissimum. Int J Cancer. 2007;121(4):884–94.

Antibacterial Activity & Phytochemical Screening Of Crude Ethanolic Extract Of Leaves Of Ocimum Gratissimum L on Listeria Monocytogenes. The Inter Jl of Microb, 4(2): 2008.-Abstract: Ethanolic extract of the leaves of Ocimum gratissimum was screened for its phytochemical and antibacterial properties on Listeria monocytogenes at varying concentrations. The Agar gel diffusion method was used to assay for the antibacterial properties on the test isolate. The results showed that the ethanolic extracts at different concentrations inhibited the growth of L monocytogenes. The concentration of 250m…

Antifungal Activity of Extracts of Scent Leaf (Ocimum gratissimum) & Alligator Pepper (Aframomum meleguetta) on the Post-Harvest Decay of Carrot in Calabar, Nigeria, Jl of Biol, Agric & Healthcare, 3(14) :2013.-Abstract: The bioactive and antifungal effects of ethanol extracts of Aframomum meleguetta & Ocimum gratissimum were investigated in vitro on causative agents of post-harvest decay of carrots. The phytochemical screening of the two plants were obtained by analysis of their extracts using established procedures. Results showed moderate presence of saponins, tannins, flavonoids, alkalo…

Shigellocidal properties of three Nigerian medicinal plants: 0cimum gratissimum, Terminalia avicennoides & Momordica balsamina Jl Health Popul Nutr. 19(30):31–5, 2001-Abstract: The prevalence of multidrug-resistant shigellae is an important concern in the treatment of shigellosis in many developing countries, & other therapies, including herbal agents, may provide an important alternative to antimicrobial agents. In this study, three Nigerian medicinal plants: Ocimum gratissimum, Terminalia avicennoides, & Momordica balsamina were investigated for their activities against multidrug-resistan…

Atividade antibacteriana In vitro de Croton campestris A., Ocimum gratissimum L. e Cordia verbenacea DC, Rev Bras de Bio, 8, (3) ;294–8, 2010.

Repellence effectiveness of essential oils from some Tanzanian Ocimum & Hyptis plant species against afro-tropical vectors of malaria & lymphatic filariasis, Jl Med Plants Res, 2012-Abstract:Essential oils from three plant species growing in Dar es Salaam, Tanzania, Ocimum gratissimum (OG), Ocimum tenuiflorum (OT) & Hyptis suaveolens (HS) all from family Labiateae, were extracted by hydrodistillation & evaluated for laboratory & field based repellency against afro-tropical vectors of malaria & lymphatic filariasis. All oils were found to exhibit high mosquito repellency activity against Ano…

Relaxant effect of essential Oil of Ocimum gratissimum on isolated ileum of guinea pig J Ethnopharm, 81: 1-4, 2002.-Abstract: The effects of the essential oil of O gratissimum L. (Labiateae) (EOOG) on guinea pig ileum were studied. EOOG (0.1-1000 microg/ml) reversibly and concentration-dependently relaxed the basal tone of the ileum and reversed the tonic contractions induced by 60 mM KCl and 10 microM acetylcholine, with IC (50) values of 23.8+/-5.2, 18.6+/-4.0 a&70.0+/-4.6 microg/ml, respectively. Our results show that EOOG exerts relaxant effects on intestinal smooth muscle, consistent w…

Smooth muscle contracting lipid-soluble principles in chromatographic fractions of Ocimum gratissimum. J. Ethnopharmacol, 18: 3-11, 1986.

Antibacterial activities of crude extract of Nigerian Spices & herbs on enteropathogens, Egypt Acad J Biol Sci, 6(2) :59-68, 2011-Abstract: this study was designed to evaluate the antibacterial activities of water and ethanolic extracts of Nigerian herbs & Spices. Methodology: Crude extracts of fresh leaves of Ocimum gratissimum, Psidium guajava, Vernonia amygdalina, Kigelia africana, Azadirachta indica, Pistia stratiotes, Euphorbia hirta, bulb of Allium sativum & Zingiber officinale & Curcuma longa, were evaluated using the agar diffusion assay method & minimal inhibitory concentration (MI…

Justification for the use of Ocimum gratissimum L in herbal medicine & its interaction with disc antibiotics, BMC, 9 :37, 2009-Abstract : The ethanolic extract of the leaves of Ocimum gratissimum L. (Lamiaceae), used in traditional medicine for the treatment of several ailments such as urinary tract, wound, skin and gastrointestinal infections, was evaluated for its antibacterial properties against four clinical bacteria isolates namely: Escherichia coli, Proteus mirabilis, Staphylococcus aureus and Pseudomonas aeruginosa and the antifungal properties using a clinical isolate of Candida alb…

Antidiarrhoeal effects of Ocimum gratissimum leaf extract in experimental animals. J. Ethnopharmacol, 68: 327-30, 1999.

Phytochemical analysis of Ocimum gratissimum by LC-ESI–MS/MS & its antioxidant & anxiolytic effects, South Afri Jl of Botany, 92-151-8, 2014-Abstract: The present study demonstrates the phytochemical analysis of O. gratissimum by LC-ESI–MS/MS which revealed the presence of various bioactive compounds such as polyphenols, flavonoids & fatty acids. The antioxidant activity of O. gratissimum was verified by an array of in vitro antioxidant assays which exhibited a strong free radical scavenging activity. OGE showed protective effects against H2O2/AAPH induced macromolecules such as DNA, protei…

Effect of ethanolic extract of Ocimum gratissimum on sodium nitrite-induced cerebellar cortex toxicity in adult Wistar rats, Jl of Experiment & Clinical Anatomy 2015 14(2):120-5.- Intoxication of nitrites mainly from food and water constitute a potential Hazard with a resultant hypoxia. Aim: The aim was to study the effects of ethanolic leaves extract of Ocimum gratissimum on sodium nitrite (NaNO2)-induced cerebellar toxicity in adult Wistar rats. Materials & Methods: Twenty-four adult Wistar rats weighing 150–250g were divided into six groups of four rats each. Group I was the control & re…

Studies on the Evaluation of Antibacterial Activities of Aloe barbadensis & Ocimum gratissimum Against Selected Zoonotic Bacterial Strains, Research-gate, 2024-Abstract: Antimicrobial resistance poses a serious public health problem throughout the world, Traditional remedies, of which 95% are derived from plants, are used in Ethiopia to cure 90% of cattle & over 80% of human patients. Traditional medicine continues to be the predominant form of healthcare in underdeveloped nations. Aloe barbadensis & Ocimum gratissimum are used to cure a variety of sick conditions, both infectious & not. Th…

Anthelmintic activity of essential Oil of Ocimum gratissimum Linn & eugénol against Haemonchus contortus. Vet. Parasitol., 109: 59-63, 2002.-Abstract: The ovicidal activity of the essential oïl of Ocimum gratissimum Linn. (Albies) & its main component eugenol was evaluated against Haemonchus contortus, gastrointestinal parasite of small ruminants. The Oil & eugenol were diluted in Tween 20 (0.5%) at five different concentrations. In the egg Hatch test, H. contortus eggs were obtained from faces of goats experimentally infected. At 0.50% concentration, the essential Oil & eugenol showed a ma…

Ethanolic Extract of Ocimum Gratissimum Leaves (Linn) rapidly Lowers Blood Glucose Levels in Diabetic Wistar Rats, Macedonian Jl of Med Sci, 4(4) :351-7, 2015. -Abstract: The present study was undertaken to investigate the effects of ethanolic extracts of Ocimum gratissimum leaves on blood glucose and weight parameters in streptozotocin induced diabetic Wistar rats. Aim: The aim was to provide information on the glucose lowering potentials of ethanolic extract of Ocimum gratissimum and also compare this effect with that seen following administration of Metformin. Material & Methods: Thirty …

Antiplasmodial & Biochemical Effects of Combination of Ethanolic Leave-extracts of Azadirachta indica and Ocimum gratissimum on Plasmodium berghei-infected Mice, African Jl of Pharmaceut Sci & Pharm, 5(1): 2017-Abstract: The present study was to compare antimalarial activities of Azadirachta indica & Ocimum gratissimum as well as to evaluate the combined effect of the combination on Plasmodium berghei-infected mice.  Curative effects against established infection were studied in chloroquine-sensitive P. berghei NK65-infected mice using the method described by Ryley and Petes in 1970.  Haema…

Preliminary clinical tests on topical preparations of Ocimum gratissimum Linn. Leaf essential oil for the treatment of Acne vulgaris. Clin. Drug Investigat. 2002; 22:313–9-Abstract:  This study was designed to determine the clinically effective concentration and most appropriate base for a topical Ocimum oil formulation in the management of acne vulgaris. Design and patients 126 subjects, mainly university undergraduates, presenting with acne vulgaris were randomly assigned to treatment with Ocimum oil preparations, a reference product (benzoyl peroxide 10% lotion) or placebo. The test samp…

ANTIVIRAL, ANTIPROTOZOAL, ANTIMALARIAL & INSECTICIDAL ACTIVITIES OF OCIMUM GRATISSIMUM L, 2017-Abstract: Ocimum gratissimum has been used in traditional medicine for curing various ailments in tropical countries. The plant with unique bioactive compounds possesses a significant medicinal value. Among numerous curative properties the plant shows strong inhibition against human viruses & parasitic protozoans. The presence of eugenol makes it a safe mosquito repellent & anti-malarial agent. Moreover, the plant causes mortality of agricultural insects in both store seed & field crops. The resea…

use of medicinal plants for the treatment of measles in Nigeria, Jl of Ethnopharmacol, 2009; 122(2):268-72-Abstract: The present study was an ethnobotanical survey of three Local Government areas of the Ijebu area of Ogun State in southwest Nigeria for plants used in the treatment of measles. Materials & methods: Unstructured interviews were conducted among both urban & rural dwellers of three major groups of Ijebu people inhabiting the area (Ijebu North, Ijebu northeast & Ijebu Ode Local Governments). Results: A total of 20 respondents constituted by herbalists, herb sellers & old people t…

Evaluation of Antibacterial Activity of Ocimum Gratissimum Against Selected Bacterial Pathogens of Public Health Concern, Research-Gate, 2025-Abstract: Ocimum gratissimum is used to treat several infectious & non-infectious diseases. Antimicrobial resistance (AMR) among bacteria to conventional antimicrobials has become a serious challenge & threat worldwide. However, the medicinal plants of Ocimum gratissimum, which are used for two Gram-positive (Staphylococcus aureus & Enterococcus faecalis) & two Gram-negative (Escherichia coli & Pseudomonas aeruginosa) bacteria, were collected from Jim…

EFFECT OF ETHANOLIC EXTRACT OF OCIMUM GRATISSIMUM (RAM TULSI) ON SEXUAL BEHAVIOUR IN MALE MICE, Int Jl of Pharm Tech Res, 1(3) :468-73, 2009.ABSTRACT: The leaves of Ocimum gratissimum Linn. (Labiateae) have been used in Ayurvedic medicine since ancient times for the treatment of male sexual disorders. The present study investigated the effect ethanolic extract of ram Tulsi on general mating behaviour, libido, potency along with its likely gastric ulceration and adverse effects on sexually normal male albino mice. The suspension of the extract was administered orally at the dose of 100, 250,…

Bio prospective Potentiality of Essential Oil of Ocimum gratissimum Linn. -An Innovative Approach for Fruit Preservation, Jl of Pharm & Biol Sci, 11 :4:.2016.-Abstract: Of late, it becomes a great problem to the cultivators for post-harvest preservation of fruits because of their proneness to be attacked by different pathogens causing rot or other necrotic lesions on fruit surface reducing their luster & market value as well. The use of synthetic compound for post-harvest preservation of fruits definitely has some drawbacks because of their permeability through rind which may cause severe h…

Extraction, Compositional Analysis & Therapeutic Studies of Essential Oils Obtained from the Leaves of Ocimum gratissimum & Leucas martinicensis. Sch. Int. Jl. Chem. Mater. Sci. 2021-Abstract: The composition & therapeutic values of the essential oils obtained from the leaves of O. gratissimum & L. martinicensis was investigated. The GC-MS results reveals the presence of bioactive compound such as eucalyptol (10.99%), estragole (48.52%) & linalool (24.49%) in O. gratissimum while for the Lmartinicensis its reveals the presence of diazoprogesterone (0.15%), Isoaromadendrene epoxide (0.10%) &…